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NSF [cytosol]
Stable Identifier
R-HSA-264471
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Vesicle-fusing ATPase, NSF_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Homo sapiens)
cis-SNARE:3xSNAP:NSF hexamer [Golgi membrane] (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
cis-Golgi cis-SNARE binds NSF and SNAPs (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
cis-SNARE:3xSNAP:NSF hexamer [Golgi membrane] (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
NSF ATPase activity dissociates cis-SNARE (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
cis-SNARE:NSF hexamer:3xSNAP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
NSF and SNAPs bind cis-SNARE complex (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
cis-SNARE:NSF hexamer:3xSNAP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
Trafficking of AMPA receptors (Homo sapiens)
Trafficking of GluR2-containing AMPA receptors (Homo sapiens)
Trafficking of GluR2-containing AMPA receptors to synapse (Homo sapiens)
NSF [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Homo sapiens)
cis-SNARE:3xSNAP:NSF hexamer [Golgi membrane] (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
cis-Golgi cis-SNARE binds NSF and SNAPs (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
cis-SNARE:3xSNAP:NSF hexamer [Golgi membrane] (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
NSF ATPase activity dissociates cis-SNARE (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
cis-SNARE:NSF hexamer:3xSNAP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
NSF and SNAPs bind cis-SNARE complex (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
cis-SNARE:NSF hexamer:3xSNAP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
NSF ATPase activity dissociates cis-SNARE at the ER (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
SEC22B:STX18:USE1:BNIP1L:3xSNAPs:NSF hexamer [endoplasmic reticulum membrane] (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
NSF and SNAPs bind cis-SNARE at the ER membrane (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
SEC22B:STX18:USE1:BNIP1L:3xSNAPs:NSF hexamer [endoplasmic reticulum membrane] (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
Intra-Golgi traffic (Homo sapiens)
ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
STX5:PalmC-YKT6:BET1L:GOSR1:NSF hexamer:3xSNAPs [Golgi membrane] (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
NSF and SNAPs bind the cis-SNARE at the Golgi (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
STX5:PalmC-YKT6:BET1L:GOSR1:NSF hexamer:3xSNAPs [Golgi membrane] (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
Retrograde transport at the Trans-Golgi-Network (Homo sapiens)
ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3:NSF hexamer:SNAPs [trans-Golgi network membrane] (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs [trans-Golgi network membrane] (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
SNAPs and NSF hexamer bind cis-SNARE at the TGN (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3:NSF hexamer:SNAPs [trans-Golgi network membrane] (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
cis-SNARE binds SNAPs and NSF hexamer at the TGN (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs [trans-Golgi network membrane] (Homo sapiens)
NSF hexamer [cytosol] (Homo sapiens)
NSF [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P46459 NSF
Gene Names
NSF
Chain
chain:1-744
Reference Genes
BioGPS Gene:4905 NSF
COSMIC (genes):NSF NSF
CTD Gene:4905 NSF
dbSNP Gene:4905 NSF
ENSEMBL:ENSG00000073969 NSF
ENSEMBL:ENSG00000276262 NSF
ENSEMBL:ENSG00000278174 NSF
HGNC:8016 NSF
KEGG Gene (Homo sapiens):4905 NSF
Monarch:4905 NSF
NCBI Gene:4905 NSF
OMIM:601633 NSF
UCSC:P46459 NSF
Reference Transcript
RefSeq:NM_006178.3 NSF
Other Identifiers
0006180181
11716972_s_at
11716973_a_at
11748462_a_at
16835064
16835087
16850337
202395_at
3723994
3724014
3724018
3724024
3724032
3724036
3724040
3724044
3724062
3724064
3724072
3724074
3724076
3724082
3724200
3724213
3724215
3724217
3724221
3724223
3724224
3724225
3724233
3724234
3724236
3724237
3724238
3724239
3724240
3724242
3724243
3724249
3724251
3724252
3724261
3724262
3724264
3724266
3724267
3724268
38719_at
4905
8007885
A_14_P125270
A_21_P0000605
A_23_P15714
A_33_P3284108
GE58871
GO:0000139
GO:0000149
GO:0000166
GO:0001921
GO:0003674
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005737
GO:0005764
GO:0005765
GO:0005773
GO:0005794
GO:0005795
GO:0005829
GO:0005886
GO:0006810
GO:0006813
GO:0006886
GO:0006887
GO:0006888
GO:0006890
GO:0006891
GO:0008150
GO:0009056
GO:0014069
GO:0015031
GO:0016192
GO:0016787
GO:0016887
GO:0017075
GO:0017137
GO:0017157
GO:0019899
GO:0019901
GO:0019905
GO:0022607
GO:0030165
GO:0035255
GO:0035494
GO:0043001
GO:0043167
GO:0043198
GO:0043226
GO:0044877
GO:0045026
GO:0045732
GO:0046872
GO:0048208
GO:0048211
GO:0061024
GO:0065003
ILMN_1680353
ILMN_1680687
ILMN_1682414
ILMN_2330845
PH_hs_0025223
TC17000598.hg
TC17000600.hg
TC17002245.hg
TC17002247.hg
TC17_ctg5_hap1000010.hg
TC17_ctg5_hap1000015.hg
g11079227_3p_at
Participant Of
hasComponent
NSF hexamer [cytosol]
Inferred To
sec18 [cytosol] (Schizosaccharomyces pombe)
Homologues of NSF [cytosol] (Drosophila melanogaster)
NSF [cytosol] (Bos taurus)
NSF [cytosol] (Canis familiaris)
NSF [cytosol] (Gallus gallus)
NSF [cytosol] (Plasmodium falciparum)
NSF [cytosol] (Sus scrofa)
NSF [cytosol] (Xenopus tropicalis)
Nsf2 [cytosol] (Drosophila melanogaster)
nsf-1 [cytosol] (Caenorhabditis elegans)
nsfA [cytosol] (Dictyostelium discoideum)
SEC18 [cytosol] (Saccharomyces cerevisiae)
comt [cytosol] (Drosophila melanogaster)
nsfa [cytosol] (Danio rerio)
Nsf [cytosol] (Mus musculus)
Nsf [cytosol] (Rattus norvegicus)
Cross References
RefSeq
NP_006169.2
OpenTargets
ENSG00000073969
GeneCards
P46459
HPA
ENSG00000073969-NSF
Ensembl
ENSP00000481714
,
ENST00000620290
,
ENST00000611398
,
ENSP00000381293
,
ENST00000398238
,
ENSP00000478614
,
ENSG00000276262
,
ENSG00000073969
,
ENSG00000278174
PRO
P46459
HMDB Protein
HMDBP01424
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54920 NAPA
1
NAPA [cytosol]
(R-HSA-264469)
0.688
3
UniProt:O75899 GABBR2
1
GABBR2 [plasma membrane]
(R-HSA-420747)
0.611
4
UniProt:Q9UBS5 GABBR1
1
GABBR1 [plasma membrane]
(R-HSA-420716)
0.571
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:P43378 PTPN9
1
PTPN9 [nucleoplasm]
(R-HSA-9008907)
0.544
2
UniProt:P42262 GRIA2
3
GRIA2 [endocytic vesicle membrane]
(R-HSA-3004487)
p-S880-GRIA2 [plasma membrane]
(R-HSA-3004500)
GRIA2 [plasma membrane]
(R-HSA-3004502)
0.544
2
UniProt:P59635 7a
3
7a [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9686193)
7a [endocytic vesicle membrane]
(R-COV-9686695)
7a [virion membrane]
(R-COV-9678204)
0.527
2
UniProt:O00471 EXOC5
2
EXOC5 [cytosol]
(R-HSA-5623383)
EXOC5 [cytosol]
(R-HSA-265045)
0.508
2
UniProt:O15155 BET1
3
BET1 [transport vesicle]
(R-HSA-6808719)
BET1 [Golgi membrane]
(R-HSA-6807743)
BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688142)
0.462
2
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