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STX10 [trans-Golgi network membrane]
Stable Identifier
R-HSA-6810999
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
trans-Golgi network membrane
Synonyms
Syntaxin-10, Syn10
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Retrograde transport at the Trans-Golgi-Network (Homo sapiens)
ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Homo sapiens)
STX10 [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3:NSF hexamer:SNAPs [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
STX10 [trans-Golgi network membrane] (Homo sapiens)
Fusion of late-endosome derived vesicles at the TGN (Homo sapiens)
RAB9:GTP:p-RABEPK:VAMP3:STX16:STX10:VTI1A:GARP complex:GCC2 dimer:late-endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
STX10 [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
STX10 [trans-Golgi network membrane] (Homo sapiens)
SNAPs and NSF hexamer bind cis-SNARE at the TGN (Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
STX10 [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3:NSF hexamer:SNAPs [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
STX10 [trans-Golgi network membrane] (Homo sapiens)
Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Homo sapiens)
RAB9:GTP:p-RABEPK:VAMP3:STX16:STX10:VTI1A:GARP complex:GCC2 dimer:late-endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
STX10 [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
STX10 [trans-Golgi network membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60499 STX10
Gene Names
STX10, SYN10
Chain
initiator methionine:1, chain:2-249
Reference Genes
BioGPS Gene:8677 STX10
COSMIC (genes):STX10 STX10
CTD Gene:8677 STX10
dbSNP Gene:8677 STX10
ENSEMBL:ENSG00000104915 STX10
HGNC:11428 STX10
KEGG:hsa:8677 STX10
Monarch:8677 STX10
NCBI Gene:8677 STX10
OMIM:603765 STX10
UCSC:O60499 STX10
Reference Transcript
RefSeq:NM_003765.3 STX10
RefSeq:NM_001271611.2 STX10
Participates
as an output of
ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Homo sapiens)
as a component of
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
Inferred To
stx10 [trans-Golgi network membrane]
(Danio rerio)
Syx6 [trans-Golgi network membrane]
(Drosophila melanogaster)
tlg1 [trans-Golgi network membrane]
(Schizosaccharomyces pombe)
Ghost homologue of STX10 [trans-Golgi network membrane]
(Caenorhabditis elegans)
Ghost homologue of STX10 [trans-Golgi network membrane]
(Dictyostelium discoideum)
Ghost homologue of STX10 [trans-Golgi network membrane]
(Gallus gallus)
Ghost homologue of STX10 [trans-Golgi network membrane]
(Mus musculus)
Ghost homologue of STX10 [trans-Golgi network membrane]
(Rattus norvegicus)
Ghost homologue of STX10 [trans-Golgi network membrane]
(Sus scrofa)
Ghost homologue of STX10 [trans-Golgi network membrane]
(Xenopus tropicalis)
STX10 [trans-Golgi network membrane]
(Bos taurus)
STX10 [trans-Golgi network membrane]
(Canis familiaris)
STX10 [trans-Golgi network membrane]
(Plasmodium falciparum)
TLG1 [trans-Golgi network membrane]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_003756.1
,
NP_001258540.1
ENSEMBL
ENSP00000339350
,
ENSP00000466298
,
ENST00000343587
,
ENST00000587230
,
ENSG00000104915
OpenTargets
ENSG00000104915
GeneCards
STX10
HPA
ENSG00000104915-STX10
PRO
O60499
Pharos - Targets
O60499
PDB
4DND
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q86Y82 STX12
0.643
5
UniProt:P54920 NAPA
1
NAPA [cytosol]
(R-HSA-264469)
0.643
3
UniProt:O15400 STX7
0.527
4
UniProt:O95183 VAMP5
0.527
3
UniProt:P0DTD8 NS7B
0.527
2
UniProt:O75379 VAMP4
4
VAMP4 [plasma membrane]
(R-HSA-8864461)
VAMP4 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869133)
VAMP4 [transport vesicle]
(R-HSA-6811023)
VAMP4 [trans-Golgi network membrane]
(R-HSA-6811021)
0.527
3
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