Reactome | DEFA1(66-94) [azurophil granule lumen]

ENSG00000240247, ENSP00000372139, ENSG00000285176, ENSP00000493747, ENSP00000372136, ENST00000382689, ENST00000644528, ENSP00000496578, ENSG00000284983, ENST00000382692, ENST00000645146, ENSG00000206047

GeneCards

DEFA1, DEFA1B

HPA

ENSG00000240247-DEFA1B, ENSG00000206047-DEFA1

PRO

P59665

Pharos - Targets

P59665

PDB

4DU0, 4LB7, 4LB1, 4LBB, 3HJD, 3LO1, 3LOE, 3LVX, 3LO2, 4LBF, 3HJ2, 3LO4, 3GNY, 2PM1, 2KHT, 3LO6, 3H6C, 3LO9

Interactors (43)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:Q9UIW2 PLXNA1	2	p-Y-PLXNA1 [plasma membrane] (R-HSA-419614) PLXNA1 [plasma membrane] (R-HSA-396932)	0.527	2
UniProt:Q01459 DIAC			0.527	2
UniProt:Q99538 LGMN	2	LGMN [endolysosome lumen] (R-HSA-8942384) LGMN [lysosomal lumen] (R-HSA-350135)	0.527	2
UniProt:O75051 PLXNA2	2	PLXNA2 [plasma membrane] (R-HSA-396934) p-Y-PLXNA2 [plasma membrane] (R-HSA-419607)	0.527	2
UniProt:Q92545 TM131			0.527	2
UniProt:P13497 BMP1	1	BMP1 [extracellular region] (R-HSA-2002393)	0.527	2
UniProt:O75976 CPD	3	CPD [Golgi membrane] (R-HSA-432675) CPD [cytoplasmic vesicle membrane] (R-HSA-432671) CPD [plasma membrane] (R-HSA-9715182)	0.527	2
UniProt:P13639 EEF2	10	EEF2 [ficolin-1-rich granule lumen] (R-HSA-6801513) EEF2 [extracellular region] (R-HSA-6806499) EEF2 [secretory granule lumen] (R-HSA-6801504) EEF2 [cytosol] (R-HSA-156901) aminocarboxypropyl EEF2 [cytosol] (R-HSA-5358478) Me-diphthine EEF2 [cytosol] (R-HSA-5367025) nascent EEF2 [cytosol] (R-HSA-5358472) diphthine EEF2 [cytosol] (R-HSA-5358501) ADP-ribo-EEF2 [cytosol] (R-HSA-5334764) Me3K525-EEF2 [cytosol] (R-HSA-8932237)	0.527	2
UniProt:P18065 IGFBP2	1	IGFBP2 [extracellular region] (R-HSA-381402)	0.527	2
UniProt:Q3LXA3 TKFC	1	TKFC [cytosol] (R-HSA-918185)	0.527	2
UniProt:P42702 LIFR	1	LIFR [plasma membrane] (R-HSA-5693181)	0.527	2
UniProt:Q92626 PXDN	1	PXDN [extracellular region] (R-HSA-2559628)	0.527	2
UniProt:P06276 BCHE	2	BCHE [plasma membrane] (R-HSA-3640835) BCHE [extracellular region] (R-HSA-434469)	0.527	2
UniProt:O00462 MANBA	3	MANBA [lysosomal lumen] (R-HSA-8853711) MANBA [plasma membrane] (R-HSA-6806257) MANBA [azurophil granule membrane] (R-HSA-6799128)	0.527	2
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936) TGFB1 [plasma membrane] (R-HSA-5146781)	0.527	2
UniProt:O94813 SLIT2	3	SLIT2(31-1121) [extracellular region] (R-HSA-426409) SLIT2(1122-1529) [extracellular region] (R-HSA-426412) SLIT2 [extracellular region] (R-HSA-375997)	0.527	2
UniProt:Q9UM47 NOTCH3	20	Ub-NICD3 [cytosol] (R-HSA-9021546) Ub-NEXT3 [plasma membrane] (R-HSA-9021545) p-Y-NICD3 [cytosol] (R-HSA-9018581) Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911429) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911419) NOTCH3(1572-2321) [Golgi membrane] (R-HSA-156995) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane] (R-HSA-1983672) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region] (R-HSA-1983675) NOTCH3(1572-2321) [plasma membrane] (R-HSA-157231) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane] (R-HSA-1472871) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] (R-HSA-1467307) 10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] (R-HSA-1467382) Pre-NOTCH3 [endoplasmic reticulum membrane] (R-HSA-157102) NICD3 [nucleoplasm] (R-HSA-157928) NICD3 [cytosol] (R-HSA-157647) NEXT3 [plasma membrane] (R-HSA-157203) NOTCH3(1629-1661) [plasma membrane] (R-HSA-157657) NOTCH3(40-1628) [extracellular region] (R-HSA-157639) FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane] (R-HSA-1911522) FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane] (R-HSA-1911517)	0.527	2
UniProt:P61916 NPC2	3	NPC2 [lysosomal lumen] (R-HSA-8876488) NPC2 [extracellular region] (R-HSA-6806224) NPC2 [azurophil granule lumen] (R-HSA-6799163)	0.527	2
UniProt:Q9BT09 CNPY3	1	CNPY3 [endoplasmic reticulum lumen] (R-HSA-1678932)	0.527	2
UniProt:O60243 HS6ST1	1	HS6ST1 [Golgi membrane] (R-HSA-2076504)	0.527	2
UniProt:Q13683 ITGA7	1	ITGA7(34-1181) [plasma membrane] (R-HSA-215940)	0.527	2
UniProt:Q9BZQ6 EDEM3	1	EDEM3 [endoplasmic reticulum quality control compartment] (R-HSA-1022110)	0.527	2
UniProt:Q9BSG0 PADC1			0.527	2
UniProt:O43405 COCH			0.527	2
UniProt:Q5HYA8 TMEM67	1	TMEM67 [ciliary membrane] (R-HSA-5626667)	0.527	2
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.527	2
UniProt:O95158 NXPH4			0.527	2
UniProt:P15848 ARSB	12	ARSB [ficolin-1-rich granule lumen] (R-HSA-6800887) ARSB [extracellular region] (R-HSA-6806236) ARSB [azurophil granule lumen] (R-HSA-6798774) ARSB [endoplasmic reticulum lumen] (R-HSA-1614331) OxA-ARSB [endoplasmic reticulum lumen] (R-HSA-1614325) OxA-ARSB [lysosomal lumen] (R-HSA-1606837) ARSB H393P [lysosomal lumen] (R-HSA-5649492) ARSB R95Q [lysosomal lumen] (R-HSA-2314614) ARSB G144R [lysosomal lumen] (R-HSA-2314612) ARSB P116H [lysosomal lumen] (R-HSA-2314619) ARSB C117R [lysosomal lumen] (R-HSA-2314618) ARSB Y86del [lysosomal lumen] (R-HSA-2314606)	0.527	2
UniProt:Q9UBX1 CTSF	1	CTSF [lysosomal lumen] (R-HSA-1181231)	0.527	2
UniProt:Q8IUL8 CILP2			0.527	2
UniProt:Q16787 LAMA3	3	LAMA3(36-?) [extracellular region] (R-HSA-2533899) LAMA3(?-3333) [extracellular region] (R-HSA-2533924) LAMA3 [extracellular region] (R-HSA-445991)	0.527	2
UniProt:P07942 LAMB1	3	LAMB1 [extracellular region] (R-HSA-215959) p-LAMB1 [endoplasmic reticulum lumen] (R-HSA-8956889) LAMB1 [endoplasmic reticulum lumen] (R-HSA-8956706)	0.527	2
UniProt:P55268 LAMB2	3	LAMB2 [extracellular region] (R-HSA-215961) p-LAMB2 [endoplasmic reticulum lumen] (R-HSA-8957053) LAMB2 [endoplasmic reticulum lumen] (R-HSA-8956752)	0.527	2
UniProt:Q9Y4K0 LOXL2	3	LOXL2(26-?) [extracellular region] (R-HSA-2022106) LOXL2 [extracellular region] (R-HSA-2022142) LOXL2(?-774) [extracellular region] (R-HSA-2022136)	0.527	2
UniProt:Q7Z6J8 UBE3D	1	UBE3D [cytosol] (R-HSA-8851647)	0.527	2
UniProt:Q9BZ76 CNTP3			0.527	2
UniProt:P48454 PPP3CC	1	PPP3CC [cytosol] (R-HSA-61113)	0.527	2
UniProt:O15031 PLXB2			0.527	2
UniProt:O15230 LAMA5	3	LAMA5(?-3695) [extracellular region] (R-HSA-3791178) LAMA5(36-?) [extracellular region] (R-HSA-3791176) LAMA5 [extracellular region] (R-HSA-215956)	0.527	2
UniProt:P30532 CHRNA5	1	CHRNA5 [plasma membrane] (R-HSA-507833)	0.527	2
UniProt:P63098 PPP3R1	2	PPP3R1 [nucleoplasm] (R-HSA-2685631) PPP3R1 [cytosol] (R-HSA-51291)	0.527	2
UniProt:P12109 COL6A1	20	GalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023521) 3x4Hyp-GlcGalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023651) GlcGalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023608) 3x4Hyp-GalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023576) 3x4Hyp-3Hyp-GalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023560) 3x4Hyp-3Hyp-GlcGalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023660) COL6A1 [endoplasmic reticulum lumen] (R-HSA-1614453) 3x4Hyp-3Hyp-GalHyl-COL6A1 [extracellular region] (R-HSA-2127538) 3x4Hyp-3Hyp-GlcGalHyl-COL6A1 [extracellular region] (R-HSA-2127522) 3x4Hyp-5Hyl-COL6A1 [extracellular region] (R-HSA-2127506) GalHyl-COL6A1 [extracellular region] (R-HSA-2127523) 3x4Hyp-GlcGalHyl-COL6A1 [extracellular region] (R-HSA-2127524) 3x4Hyp-3Hyp-5Hyl-COL6A1 [extracellular region] (R-HSA-2127527) 3x4Hyp-COL6A1 [extracellular region] (R-HSA-2127464) COL6A1 [extracellular region] (R-HSA-2127512) 3x4Hyp-3Hyp-COL6A1 [extracellular region] (R-HSA-2127484) 3x4Hyp-GalHyl-COL6A1 [extracellular region] (R-HSA-2127501) GlcGalHyl-COL6A1 [extracellular region] (R-HSA-2127486) 5Hyl-COL6A1 [extracellular region] (R-HSA-2127519) 3x4Hyp-GlcGalHyl-COL6A1(?-1028) [extracellular region] (R-HSA-2470119)	0.527	2

Cite Us!