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DEFA1(65-94) [azurophil granule lumen]
Stable Identifier
R-HSA-1470053
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
azurophil granule lumen
Synonyms
Defensin alpha 1, DEFA1, Neutrophil defensin 1, DEF1_HUMAN, HNP-1
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)
DEFA1(65-94) [azurophil granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P59665 DEFA1
Gene Names
DEFA1, DEF1, DEFA2, MRS, DEFA1B
Chain
signal peptide:1-19, propeptide:20-38, chain:39-94, peptide:65-94, peptide:66-94
Reference Genes
COSMIC (genes):DEFA1 DEFA1
COSMIC (genes):DEFA1B DEFA1
dbSNP Gene:1667 DEFA1
dbSNP Gene:728358 DEFA1
ENSEMBL:ENSG00000206047 DEFA1
ENSEMBL:ENSG00000240247 DEFA1
Participates
as a member of
Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)
Other forms of this molecule
DEFA1(20-94) [Golgi lumen]
DEFA1(66-94) [Golgi lumen]
DEFA1(20-65) [Golgi lumen]
DEFA1(1-94) [Golgi lumen]
DEFA1(66-94) [extracellular region]
DEFA1(66-94) [azurophil granule lumen]
DEFA1(65-94) [extracellular region]
omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region]
Inferred To
Np4 [azurophil granule lumen]
(Rattus norvegicus)
Defa25 [azurophil granule lumen]
(Mus musculus)
ENSRNOG00000064390 [azurophil granule lumen]
(Rattus norvegicus)
AY761185 [azurophil granule lumen]
(Mus musculus)
Defa36 [azurophil granule lumen]
(Mus musculus)
Defa9 [azurophil granule lumen]
(Rattus norvegicus)
Defa31 [azurophil granule lumen]
(Mus musculus)
Defa31 [azurophil granule lumen]
(Rattus norvegicus)
Defa35 [azurophil granule lumen]
(Mus musculus)
Defa24 [azurophil granule lumen]
(Mus musculus)
Defa24 [azurophil granule lumen]
(Rattus norvegicus)
Defa29 [azurophil granule lumen]
(Mus musculus)
Defa42 [azurophil granule lumen]
(Mus musculus)
Defa5 [azurophil granule lumen]
(Mus musculus)
Defa20 [azurophil granule lumen]
(Mus musculus)
Defa8 [azurophil granule lumen]
(Rattus norvegicus)
Defa26 [azurophil granule lumen]
(Mus musculus)
Defa41 [azurophil granule lumen]
(Mus musculus)
Defa30 [azurophil granule lumen]
(Mus musculus)
Defa34 [azurophil granule lumen]
(Mus musculus)
Defa23 [azurophil granule lumen]
(Mus musculus)
Defal1 [azurophil granule lumen]
(Rattus norvegicus)
Homologues of DEFA3(65-94) [azurophil granule lumen]
(Mus musculus)
Homologues of DEFA3(65-94) [azurophil granule lumen]
(Rattus norvegicus)
Defa40 [azurophil granule lumen]
(Mus musculus)
Defa3 [azurophil granule lumen]
(Mus musculus)
Defa38 [azurophil granule lumen]
(Mus musculus)
Defa [azurophil granule lumen]
(Rattus norvegicus)
Defa22 [azurophil granule lumen]
(Mus musculus)
Defa11 [azurophil granule lumen]
(Rattus norvegicus)
Defa17 [azurophil granule lumen]
(Mus musculus)
Defa2 [azurophil granule lumen]
(Mus musculus)
Defa39 [azurophil granule lumen]
(Mus musculus)
Defa28 [azurophil granule lumen]
(Mus musculus)
Defa21 [azurophil granule lumen]
(Mus musculus)
Defa6 [azurophil granule lumen]
(Rattus norvegicus)
DEFA3(65-94) [azurophil granule lumen]
(Mus musculus)
DEFA3(65-94) [azurophil granule lumen]
(Rattus norvegicus)
Interactors (43)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
UniProt:Q9UIW2 PLXNA1
2
PLXNA1 [plasma membrane]
(R-HSA-396932)
p-Y-PLXNA1 [plasma membrane]
(R-HSA-419614)
0.527
2
UniProt:Q01459 DIAC
0.527
2
UniProt:O75051 PLXNA2
2
PLXNA2 [plasma membrane]
(R-HSA-396934)
p-Y-PLXNA2 [plasma membrane]
(R-HSA-419607)
0.527
2
UniProt:Q92545 TM131
0.527
2
UniProt:P13497 BMP1
1
BMP1 [extracellular region]
(R-HSA-2002393)
0.527
2
UniProt:O75976 CPD
3
CPD [Golgi membrane]
(R-HSA-432675)
CPD [cytoplasmic vesicle membrane]
(R-HSA-432671)
CPD [plasma membrane]
(R-HSA-9715182)
0.527
2
UniProt:P12109 COL6A1
20
GalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023521)
3x4Hyp-GlcGalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023651)
GlcGalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023608)
3x4Hyp-GalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023576)
3x4Hyp-3Hyp-GalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023560)
3x4Hyp-3Hyp-GlcGalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023660)
COL6A1 [endoplasmic reticulum lumen]
(R-HSA-1614453)
3x4Hyp-3Hyp-GalHyl-COL6A1 [extracellular region]
(R-HSA-2127538)
3x4Hyp-3Hyp-GlcGalHyl-COL6A1 [extracellular region]
(R-HSA-2127522)
3x4Hyp-5Hyl-COL6A1 [extracellular region]
(R-HSA-2127506)
GalHyl-COL6A1 [extracellular region]
(R-HSA-2127523)
3x4Hyp-GlcGalHyl-COL6A1 [extracellular region]
(R-HSA-2127524)
3x4Hyp-3Hyp-5Hyl-COL6A1 [extracellular region]
(R-HSA-2127527)
3x4Hyp-COL6A1 [extracellular region]
(R-HSA-2127464)
COL6A1 [extracellular region]
(R-HSA-2127512)
3x4Hyp-3Hyp-COL6A1 [extracellular region]
(R-HSA-2127484)
3x4Hyp-GalHyl-COL6A1 [extracellular region]
(R-HSA-2127501)
GlcGalHyl-COL6A1 [extracellular region]
(R-HSA-2127486)
5Hyl-COL6A1 [extracellular region]
(R-HSA-2127519)
3x4Hyp-GlcGalHyl-COL6A1(?-1028) [extracellular region]
(R-HSA-2470119)
0.527
2
UniProt:P13639 EEF2
10
EEF2 [secretory granule lumen]
(R-HSA-6801504)
EEF2 [extracellular region]
(R-HSA-6806499)
EEF2 [ficolin-1-rich granule lumen]
(R-HSA-6801513)
EEF2 [cytosol]
(R-HSA-156901)
aminocarboxypropyl EEF2 [cytosol]
(R-HSA-5358478)
Me-diphthine EEF2 [cytosol]
(R-HSA-5367025)
nascent EEF2 [cytosol]
(R-HSA-5358472)
diphthine EEF2 [cytosol]
(R-HSA-5358501)
ADP-ribo-EEF2 [cytosol]
(R-HSA-5334764)
Me3K525-EEF2 [cytosol]
(R-HSA-8932237)
0.527
2
UniProt:Q9UM47 NOTCH3
20
Ub-NICD3 [cytosol]
(R-HSA-9021546)
Ub-NEXT3 [plasma membrane]
(R-HSA-9021545)
p-Y-NICD3 [cytosol]
(R-HSA-9018581)
Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
(R-HSA-1911429)
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
(R-HSA-1911419)
NOTCH3(1572-2321) [Golgi membrane]
(R-HSA-156995)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane]
(R-HSA-1983672)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region]
(R-HSA-1983675)
NOTCH3(1572-2321) [plasma membrane]
(R-HSA-157231)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane]
(R-HSA-1472871)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]
(R-HSA-1467307)
10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]
(R-HSA-1467382)
Pre-NOTCH3 [endoplasmic reticulum membrane]
(R-HSA-157102)
NICD3 [nucleoplasm]
(R-HSA-157928)
NICD3 [cytosol]
(R-HSA-157647)
NEXT3 [plasma membrane]
(R-HSA-157203)
NOTCH3(1629-1661) [plasma membrane]
(R-HSA-157657)
NOTCH3(40-1628) [extracellular region]
(R-HSA-157639)
FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane]
(R-HSA-1911522)
FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane]
(R-HSA-1911517)
0.527
2
UniProt:P42702 LIFR
1
LIFR [plasma membrane]
(R-HSA-5693181)
0.527
2
UniProt:O94813 SLIT2
3
SLIT2(31-1121) [extracellular region]
(R-HSA-426409)
SLIT2(1122-1529) [extracellular region]
(R-HSA-426412)
SLIT2 [extracellular region]
(R-HSA-375997)
0.527
2
UniProt:Q3LXA3 TKFC
1
TKFC [cytosol]
(R-HSA-918185)
0.527
2
UniProt:Q9BT09 CNPY3
1
CNPY3 [endoplasmic reticulum lumen]
(R-HSA-1678932)
0.527
2
UniProt:P06276 BCHE
2
BCHE [plasma membrane]
(R-HSA-3640835)
BCHE [extracellular region]
(R-HSA-434469)
0.527
2
UniProt:Q92626 PXDN
1
PXDN [extracellular region]
(R-HSA-2559628)
0.527
2
UniProt:O00462 MANBA
3
MANBA [lysosomal lumen]
(R-HSA-8853711)
MANBA [plasma membrane]
(R-HSA-6806257)
MANBA [azurophil granule membrane]
(R-HSA-6799128)
0.527
2
UniProt:Q99538 LGMN
2
LGMN [endolysosome lumen]
(R-HSA-8942384)
LGMN [lysosomal lumen]
(R-HSA-350135)
0.527
2
UniProt:O60243 HS6ST1
1
HS6ST1 [Golgi membrane]
(R-HSA-2076504)
0.527
2
UniProt:Q13683 ITGA7
1
ITGA7(34-1181) [plasma membrane]
(R-HSA-215940)
0.527
2
UniProt:Q9BZQ6 EDEM3
1
EDEM3 [endoplasmic reticulum quality control compartment]
(R-HSA-1022110)
0.527
2
UniProt:Q9BSG0 PADC1
0.527
2
UniProt:O43405 COCH
0.527
2
UniProt:P18065 IGFBP2
1
IGFBP2 [extracellular region]
(R-HSA-381402)
0.527
2
UniProt:Q5HYA8 TMEM67
1
TMEM67 [ciliary membrane]
(R-HSA-5626667)
0.527
2
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.527
2
UniProt:P01137 TGFB1
7
TGFB1 [extracellular region]
(R-HSA-170838)
TGFB1(30-278) [extracellular region]
(R-HSA-2395367)
TGFB1(30-278) [Golgi lumen]
(R-HSA-9736812)
TGFB1 [Golgi lumen]
(R-HSA-177108)
TGFB1(30-390) [Golgi lumen]
(R-HSA-114705)
TGFB1 [plasma membrane]
(R-HSA-5146781)
TGFB1(30-278) [platelet alpha granule lumen]
(R-HSA-65936)
0.527
2
UniProt:O95158 NXPH4
0.527
2
UniProt:P15848 ARSB
12
ARSB [azurophil granule lumen]
(R-HSA-6798774)
ARSB [extracellular region]
(R-HSA-6806236)
ARSB [ficolin-1-rich granule lumen]
(R-HSA-6800887)
ARSB [endoplasmic reticulum lumen]
(R-HSA-1614331)
OxA-ARSB [endoplasmic reticulum lumen]
(R-HSA-1614325)
OxA-ARSB [lysosomal lumen]
(R-HSA-1606837)
ARSB H393P [lysosomal lumen]
(R-HSA-5649492)
ARSB R95Q [lysosomal lumen]
(R-HSA-2314614)
ARSB G144R [lysosomal lumen]
(R-HSA-2314612)
ARSB P116H [lysosomal lumen]
(R-HSA-2314619)
ARSB C117R [lysosomal lumen]
(R-HSA-2314618)
ARSB Y86del [lysosomal lumen]
(R-HSA-2314606)
0.527
2
UniProt:Q9UBX1 CTSF
1
CTSF [lysosomal lumen]
(R-HSA-1181231)
0.527
2
UniProt:Q8IUL8 CILP2
0.527
2
UniProt:Q16787 LAMA3
3
LAMA3(36-?) [extracellular region]
(R-HSA-2533899)
LAMA3(?-3333) [extracellular region]
(R-HSA-2533924)
LAMA3 [extracellular region]
(R-HSA-445991)
0.527
2
UniProt:P61916 NPC2
3
NPC2 [lysosomal lumen]
(R-HSA-8876488)
NPC2 [extracellular region]
(R-HSA-6806224)
NPC2 [azurophil granule lumen]
(R-HSA-6799163)
0.527
2
UniProt:P07942 LAMB1
3
LAMB1 [extracellular region]
(R-HSA-215959)
p-LAMB1 [endoplasmic reticulum lumen]
(R-HSA-8956889)
LAMB1 [endoplasmic reticulum lumen]
(R-HSA-8956706)
0.527
2
UniProt:P55268 LAMB2
3
LAMB2 [extracellular region]
(R-HSA-215961)
p-LAMB2 [endoplasmic reticulum lumen]
(R-HSA-8957053)
LAMB2 [endoplasmic reticulum lumen]
(R-HSA-8956752)
0.527
2
UniProt:Q9Y4K0 LOXL2
3
LOXL2(26-?) [extracellular region]
(R-HSA-2022106)
LOXL2 [extracellular region]
(R-HSA-2022142)
LOXL2(?-774) [extracellular region]
(R-HSA-2022136)
0.527
2
UniProt:Q7Z6J8 UBE3D
1
UBE3D [cytosol]
(R-HSA-8851647)
0.527
2
UniProt:Q9BZ76 CNTP3
0.527
2
UniProt:P48454 PPP3CC
1
PPP3CC [cytosol]
(R-HSA-61113)
0.527
2
UniProt:O15031 PLXB2
0.527
2
UniProt:O15230 LAMA5
3
LAMA5(?-3695) [extracellular region]
(R-HSA-3791178)
LAMA5(36-?) [extracellular region]
(R-HSA-3791176)
LAMA5 [extracellular region]
(R-HSA-215956)
0.527
2
UniProt:P30532 CHRNA5
1
CHRNA5 [plasma membrane]
(R-HSA-507833)
0.527
2
UniProt:P63098 PPP3R1
2
PPP3R1 [nucleoplasm]
(R-HSA-2685631)
PPP3R1 [cytosol]
(R-HSA-51291)
0.527
2
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