Reactome | IL-6-type cytokine receptor ligand interactions

IL-6-type cytokine receptor ligand interactions

Stable Identifier

R-HSA-6788467

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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IL-6-type cytokine receptor ligand interactions

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The members involved in (interleukin)-6-type cytokine signalling are the IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM (oncostatin M), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CTF1) and cardiotrophin-like cytokine factor 1 (CLCF1). Receptors involved in recognition of the IL-6-type cytokines can be subdivided in the non-signalling alpha-receptors (IL6R, IL 11R, and CNTFR) and the signal transducing receptors (gp130, LIFR, and OSMR). The latter associate with JAKs and become tyrosine phosphorylated in response to cytokine stimulation (Heinrich et al. 1998, 2003). IL27 and IL35 belongs to IL12 cytokine family but they share gp130 as a component of signalling receptor, along with IL-6, IL-11, LIF, OSM, CNTF, CTF1 and CLCF1.

Literature References

PubMed ID	Title	Journal	Year
9716487	Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway Heinrich, PC, Schaper, F, Behrmann, I, Müller-Newen, G, Graeve, L	Biochem. J.	1998
12773095	Principles of interleukin (IL)-6-type cytokine signalling and its regulation Schaper, F, Heinrich, PC, Behrmann, I, Haan, S, Hermanns, HM, Müller-Newen, G	Biochem J	2003