Reactome | CRLF1 binds CLCF1

CRLF1 binds CLCF1

Stable Identifier

R-HSA-6783670

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Cardiotrophin-like cytokine factor 1 (CLCF1 also referred as NNT1 or BSF3) binds to the tripartite CNTFR complex and activates Jak-STAT, MAPK and PI3/Akt signaling pathways in various cell systems. Function of CLCF1 includes neurotrophic and B cell stimulatory effects, as well as neuroimmunoendocrine modulation of corticotroph function. Cellular secretion of CLCF1 requires heteromeric complex formation with other IL-6 family member cytokine receptor-like factor 1 (CRLF1 also called CLF1). It is a secreted receptor belonging to the interleukin-6 family of cytokines. This heteromeric CRLF1:CLCF1 is a stable sectreted complex that acts as a second ligand for ciliary neurotrophic factor receptor (CNTFR) tripartite receptor complex (Elson et al. 2000, Vlotides et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15450249	Novel neurotrophin-1/B cell-stimulating factor-3 (NNT-1/BSF-3)/cardiotrophin-like cytokine (CLC)--a novel gp130 cytokine with pleiotropic functions Vlotides, G, Zitzmann, K, Stalla, GK, Auernhammer, CJ	Cytokine Growth Factor Rev.	2004
10966616	CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex Elson, GC, Lelièvre, E, Guillet, C, Chevalier, S, Plun-Favreau, H, Froger, J, Suard, I, de Coignac, AB, Delneste, Y, Bonnefoy, JY, Gauchat, JF, Gascan, H	Nat. Neurosci.	2000