Reactome | OSM,LIF,CTF1 receptor complex binds gp130

OSM,LIF,CTF1 receptor complex binds gp130

Stable Identifier

R-HSA-6783524

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

OSM,LIF,CTF1 receptor complex binds gp130

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Glycoprotein (gp)130 is the common signal transducer for LIF, OSM and CTF1 receptor complexes. gp130/OSMRbeta complex is used solely by OSM, the gp130/LIFR complex is shared by the three receptors LIF, OSM and CTF1. Binding of OSM to either the gp130/LIFR or the gp130/OSMRbeta complex triggers the activation of multiple members of the Janus kinase (JAK) family.

Literature References

PubMed ID	Title	Journal	Year
2779549	Molecular cloning, sequence analysis, and functional expression of a novel growth regulator, oncostatin M Malik, N, Kallestad, JC, Gunderson, NL, Austin, SD, Neubauer, MG, Ochs, V, Marquardt, H, Zarling, JM, Shoyab, M, Wei, CM	Mol. Cell. Biol.	1989
15519241	LIF receptor signaling modulates neural stem cell renewal Pitman, M, Emery, B, Binder, M, Wang, S, Butzkueven, H, Kilpatrick, TJ	Mol. Cell. Neurosci.	2004