Reactome | OSM,LIF,CTF1 receptor complex binds gp130

OSM,LIF,CTF1 receptor complex binds gp130

Stable Identifier

R-HSA-6783524

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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OSM,LIF,CTF1 receptor complex binds gp130

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Glycoprotein (gp)130 is the common signal transducer for LIF, OSM and CTF1 receptor complexes. gp130/OSMRbeta complex is used solely by OSM, the gp130/LIFR complex is shared by the three receptors LIF, OSM and CTF1. Binding of OSM to either the gp130/LIFR or the gp130/OSMRbeta complex triggers the activation of multiple members of the Janus kinase (JAK) family.

Literature References

PubMed ID	Title	Journal	Year
2779549	Molecular cloning, sequence analysis, and functional expression of a novel growth regulator, oncostatin M Kallestad, JC, Ochs, V, Neubauer, MG, Shoyab, M, Malik, N, Wei, CM, Zarling, JM, Austin, SD, Marquardt, H, Gunderson, NL	Mol. Cell. Biol.	1989
15519241	LIF receptor signaling modulates neural stem cell renewal Binder, M, Butzkueven, H, Wang, S, Emery, B, Pitman, M, Kilpatrick, TJ	Mol. Cell. Neurosci.	2004