Reactome | IL31:IL31RA:JAK1 binds OSMR:JAK1

IL31:IL31RA:JAK1 binds OSMR:JAK1

Stable Identifier

R-HSA-448660

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

ReviewStatus

5/5

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Interleukin-31 (IL31) signals via a heterodimeric receptor composed of Interleukin-31 receptor A (IL31RA) and the Oncostatin M receptor (OSMR). IL31 binds first to IL31RA (LeSaux et al. 2010). This initial binding is essential for subsequent binding to OSMR, possibly because binding induces a conformational change in IL31. The resulting IL31:IL31RA complex recruits OSMR, which increases the strength of IL31 binding and is essential for subsequent STAT signaling (Diveu et al. 2004, Maier et al. 2015). As the pre-association of IL31RA with JAK1 is unproven this event is represented as a black-box.

Literature References

PubMed ID	Title	Journal	Year
19920145	Molecular dissection of human interleukin-31-mediated signal transduction through site-directed mutagenesis Gascan, H, Danger, Y, Ravon, E, Le Saux, S, Rousseau, F, Froger, J, Grimaud, L, Chevalier, S, Barbier, F	J. Biol. Chem.	2010