Reactome | JAKs bind OSMR

JAKs bind OSMR

Stable Identifier

R-HSA-6784204

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Leukemia inhibitory factor receptor (LIFR) beta and Oncostatin M receptor (OSMR) constitutively associates with the JAK-TYK family of cytoplasmic protein tyrosine kinases in the absence of ligand. Activation of these kinases occur as a result of ligand-induced heterodimerzation of LIFR beta or OSMR with gp130 (Stahl et al. 1994, Hermanns et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
8272873	Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components Stahl, N, Boulton, TG, Farruggella, T, Ip, NY, Davis, S, Witthuhn, BA, Quelle, FW, Silvennoinen, O, Barbieri, G, Pellegrini, S	Science	1994
10586060	Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130 Hermanns, HM, Radtke, S, Haan, C, Schmitz-Van de Leur, H, Tavernier, J, Heinrich, PC, Behrmann, I	J. Immunol.	1999