Leukemia inhibitory factor receptor (LIFR) beta and Oncostatin M receptor (OSMR) constitutively associates with the JAK-TYK family of cytoplasmic protein tyrosine kinases in the absence of ligand. Activation of these kinases occur as a result of ligand-induced heterodimerzation of LIFR beta or OSMR with gp130 (Stahl et al. 1994, Hermanns et al. 2000).
Witthuhn, BA, Barbieri, G, Pellegrini, S, Quelle, FW, Ip, NY, Silvennoinen, O, Davis, S, Boulton, TG, Stahl, N, Farruggella, T
Heinrich, PC, Behrmann, I, Tavernier, J, Radtke, S, Hermanns, HM, Haan, C, Schmitz-Van de Leur, H
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