Reactome | JAKs bind LIFR

JAKs bind LIFR

Stable Identifier

R-HSA-6784189

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Leukemia inhibitory factor receptor (LIFR) beta and Oncostatin M receptor (OSMR) constitutively associates with the JAK-TYK family of cytoplasmic protein tyrosine kinases in the absence of ligand. Activation of these kinases occur as a result of ligand-induced heterodimerzation of LIFR beta or OSMR with gp130 (Stahl et al. 1994, Hermanns et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
8272873	Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components Witthuhn, BA, Barbieri, G, Pellegrini, S, Quelle, FW, Ip, NY, Silvennoinen, O, Davis, S, Boulton, TG, Stahl, N, Farruggella, T	Science	1994
10586060	Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130 Heinrich, PC, Behrmann, I, Tavernier, J, Radtke, S, Hermanns, HM, Haan, C, Schmitz-Van de Leur, H	J. Immunol.	1999