JAKs bind LIFR

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Leukemia inhibitory factor receptor (LIFR) beta and Oncostatin M receptor (OSMR) constitutively associates with the JAK-TYK family of cytoplasmic protein tyrosine kinases in the absence of ligand. Activation of these kinases occur as a result of ligand-induced heterodimerzation of LIFR beta or OSMR with gp130 (Stahl et al. 1994, Hermanns et al. 2000).

Literature References
PubMed ID Title Journal Year
10586060 Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130

Hermanns, HM, Radtke, S, Haan, C, Schmitz-Van de Leur, H, Tavernier, J, Heinrich, PC, Behrmann, I

J. Immunol. 1999
8272873 Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

Stahl, N, Boulton, TG, Farruggella, T, Ip, NY, Davis, S, Witthuhn, BA, Quelle, FW, Silvennoinen, O, Barbieri, G, Pellegrini, S

Science 1994
Participant Of
Orthologous Events
Cite Us!