IL11 binds IL11RA

Stable Identifier
R-HSA-449829
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Interleukin-11 receptor alpha chain binds Interleukin-11
Locations in the PathwayBrowser
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The Interleukin-11 receptor alpha chain (IL11RA) belongs to the IL6 receptor family. Interleukin-11 (IL11) first interacts with IL11RA with a low affinity (Kd = 10 nM) forming an IL11:IL11RA complex which subsequently interacts with Interleukin-6 receptor beta subunit (IL6ST,gp130) forming a high-affinity (Kd = 300–800 pM) and signal-transducing complex (Yin et al. 1993, Hilton et al. 1994).

Literature References
PubMed ID Title Journal Year
7670098 Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11

Chérel, M, Sorel, M, Lebeau, B, Dubois, S, Moreau, JF, Bataille, R, Minvielle, S, Jacques, Y

Blood 1995
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created