IL11 binds IL11RA

Stable Identifier
R-HSA-449829
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
Interleukin-11 receptor alpha chain binds Interleukin-11
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
IL11 binds IL11RA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The Interleukin-11 receptor alpha chain (IL11RA) belongs to the IL6 receptor family. Interleukin-11 (IL11) first interacts with IL11RA with a low affinity (Kd = 10 nM) forming an IL11:IL11RA complex which subsequently interacts with Interleukin-6 receptor beta subunit (IL6ST,gp130) forming a high-affinity (Kd = 300–800 pM) and signal-transducing complex (Yin et al. 1993, Hilton et al. 1994).

Literature References
PubMed ID Title Journal Year
7670098 Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11

Dubois, S, Bataille, R, Sorel, M, Moreau, JF, Chérel, M, Lebeau, B, Minvielle, S, Jacques, Y

Blood 1995
Participants
Input
Output
Participates
as an event of
Orthologous Events
IL11 binds IL11RA (Danio rerio)
IL11 binds IL11RA (Gallus gallus)
IL11 binds IL11RA (Mus musculus)
IL11 binds IL11RA (Rattus norvegicus)
IL11 binds IL11RA (Sus scrofa)
IL11 binds IL11RA (Xenopus tropicalis)
Authored
Jupe, S  (2009-12-07)
Reviewed
Tanaka, M  (2015-11-09)
Narazaki, M  (2015-11-09)
Created
Jupe, S  (2009-12-07)
Cite Us!