IL11 binds IL11RA

Stable Identifier
R-HSA-449829
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
Interleukin-11 receptor alpha chain binds Interleukin-11
ReviewStatus
5/5
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IL11 binds IL11RA
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The Interleukin-11 receptor alpha chain (IL11RA) belongs to the IL6 receptor family. Interleukin-11 (IL11) first interacts with IL11RA with a low affinity (Kd = 10 nM) forming an IL11:IL11RA complex which subsequently interacts with Interleukin-6 receptor beta subunit (IL6ST,gp130) forming a high-affinity (Kd = 300–800 pM) and signal-transducing complex (Yin et al. 1993, Hilton et al. 1994).
Literature References
PubMed ID Title Journal Year
7670098 Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11

Chérel, M, Sorel, M, Lebeau, B, Dubois, S, Moreau, JF, Bataille, R, Minvielle, S, Jacques, Y

Blood 1995
Participants
Input
Output
Participates
as an event of
Orthologous Events
IL11 binds IL11RA (Canis familiaris)
IL11 binds IL11RA (Mus musculus)
IL11 binds IL11RA (Rattus norvegicus)
IL11 binds IL11RA (Sus scrofa)
IL11 binds IL11RA (Xenopus tropicalis)
Authored
Jupe, S  (2009-12-07)
Reviewed
Narazaki, M  (2015-11-09)
Tanaka, M  (2015-11-09)
Created
Jupe, S  (2009-12-07)
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