Reactome | CTF1 binds LIFR:JAKs

CTF1 binds LIFR:JAKs

Stable Identifier

R-HSA-5696482

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Cardiotrophin-1 (CTF1/CT-1) is a member of the IL-6 family of cytokines which was originally discovered as a factor which can induce hypertrophy of cardiac myocytes both in vitro and in vivo (Pennica et al. 1995a). Subsequently, CTF1 has been shown to have a wide variety of different effects on cardiac and non cardiac cells including the ability to stimulate the survival of both cardiac and neuronal cells (Latchman 1999). Leukemia inhibitory factor (LIF), CTF1, and oncostatin M (OSM) are four helix bundle cytokines acting through a common heterodimeric receptor composed of gp130 and LIF receptor (LIFR) (Pennica et al. 1995b).

Literature References

PubMed ID	Title	Journal	Year
7862649	Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy Pennica, D, King, KL, Shaw, KJ, Luis, E, Rullamas, J, Luoh, SM, Darbonne, WC, Knutzon, DS, Yen, R, Chien, KR	Proc. Natl. Acad. Sci. U.S.A.	1995
11834704	Cardiotrophin-1 stimulation of cardiac fibroblast growth: roles for glycoprotein 130/leukemia inhibitory factor receptor and the endothelin type A receptor Tsuruda, T, Jougasaki, M, Boerrigter, G, Huntley, BK, Chen, HH, D'Assoro, AB, Lee, SC, Larsen, AM, Cataliotti, A, Burnett, JC	Circ. Res.	2002
7738033	Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex Pennica, D, Shaw, KJ, Swanson, TA, Moore, MW, Shelton, DL, Zioncheck, KA, Rosenthal, A, Taga, T, Paoni, NF, Wood, WI	J. Biol. Chem.	1995