gp130:JAKs bind CNTFR

Stable Identifier
R-HSA-6783530
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
gp130:JAKs bind CNTFR
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Members of the interleukin-6 (IL-6) cytokines, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM) cardiotrophin-1 (CT-1) and cardiotrophin-like cytokine (CLC) share one or both of the receptor signal transducing subunits glycoprotein (gp) 130 and LIFR in their respective receptor complexes (Taga et al. 1997). gp130 (also known as CD130) is the central signal transducer of the interleukin-6 (IL6)-related cytokines. It is expressed in almost all organs, including heart, kidney, spleen, liver, lung, placenta, and brain. Mice lacking gp130 gene results in embryonic lethality at day 12.5 (Yoshida et al. 1996). CNTFR alpha bound to CNTFR or CLCF1:CRLF1 complex recruits gp130 by binding to the cytokine-binding domain (CBD) of gp130 (Man et al. 2003).
Literature References
Participants
Input
Output
Participates
as an event of
Orthologous Events
gp130:JAKs bind CNTFR (Bos taurus)
gp130:JAKs bind CNTFR (Canis familiaris)
gp130:JAKs bind CNTFR (Danio rerio)
gp130:JAKs bind CNTFR (Mus musculus)
gp130:JAKs bind CNTFR (Rattus norvegicus)
gp130:JAKs bind CNTFR (Sus scrofa)
Authored
Garapati, P V  (2015-07-21)
Reviewed
Tanaka, M  (2015-11-09)
Narazaki, M  (2015-11-09)
Created
Garapati, P V  (2015-06-16)
Cite Us!