gp130:JAKs bind CNTFR

Stable Identifier
R-HSA-6783530
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
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gp130:JAKs bind CNTFR
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Members of the interleukin-6 (IL-6) cytokines, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM) cardiotrophin-1 (CT-1) and cardiotrophin-like cytokine (CLC) share one or both of the receptor signal transducing subunits glycoprotein (gp) 130 and LIFR in their respective receptor complexes (Taga et al. 1997). gp130 (also known as CD130) is the central signal transducer of the interleukin-6 (IL6)-related cytokines. It is expressed in almost all organs, including heart, kidney, spleen, liver, lung, placenta, and brain. Mice lacking gp130 gene results in embryonic lethality at day 12.5 (Yoshida et al. 1996). CNTFR alpha bound to CNTFR or CLCF1:CRLF1 complex recruits gp130 by binding to the cytokine-binding domain (CBD) of gp130 (Man et al. 2003).

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Orthologous Events
gp130:JAKs bind CNTFR (Bos taurus)
gp130:JAKs bind CNTFR (Canis familiaris)
gp130:JAKs bind CNTFR (Gallus gallus)
gp130:JAKs bind CNTFR (Mus musculus)
gp130:JAKs bind CNTFR (Rattus norvegicus)
gp130:JAKs bind CNTFR (Sus scrofa)
Authored
Garapati, P V  (2015-07-21)
Reviewed
Narazaki, M  (2015-11-09)
Tanaka, M  (2015-11-09)
Created
Garapati, P V  (2015-06-16)