Reactome | LIFR:JAKs bind gp130:JAKs:CNTFR

LIFR:JAKs bind gp130:JAKs:CNTFR

Stable Identifier

R-HSA-6783556

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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The cytokine receptor gp130 is the shared signalling subunit of the interleukin (IL)-6-type cytokines. IL-6 and IL-11 signal through gp130 homodimer whereas leukaemia inhibitory factor (LIF), ciliary neurotrophic factor receptor (CNTFR), Cardiotrophin-like cytokine factor 1 (CLCF1), Cardiotrophin-1 (CT-1) and Oncostatin-M (OSM) exerts its action through a heterodimer of gp130 and the LIF receptor (LIFR) (Heinrich et al. 2003, Giese et al. 2005). LIFR beta structure closely resembles that of gp130 and upon ligand binding forms gp130:LIFR beta heterodimer. Finally CNTFR alpha complexed with this signal transducing heterodimer converts into functional tripartite CNTF receptor and induces phosphorylation of both gp130 and LIFR beta (Davis et al. 1993, Stahl & Yancopoulos 1994). Formation of the tripartite complex then leads to activation of Janus family kinases, JAK1, 2, 3, and TYK2 and phosphorylation of tyrosine residues on the cytoplasmic domain of gp130 (Kass 2011).

Literature References

PubMed ID	Title	Journal	Year
16051226	The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling Smith, DK, Ip, NY, Gong, K, He, W	FEBS Lett.	2005
9238703	Expression of leukaemia inhibitory factor receptor subunits LIFR beta and gp130 in human oocytes and preimplantation embryos Mummery, CL, Junca, AM, Plachot, M, Belaisch-Allart, J, van Eijk, MJ, Salat-Baroux, J, Mandelbaum, J	Mol. Hum. Reprod.	1996
8390097	LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor Kishimoto, T, Stahl, N, Pan, L, Ip, NY, Yancopoulos, GD, Davis, S, Taga, T, Aldrich, TH	Science	1993
11943154	Membrane distal cytokine binding domain of LIFR interacts with soluble CNTFR in vitro Smith, DK, Ip, NY, Gong, K, Zhu, G, He, W	FEBS Lett.	2002