CRLF1:CLCF1 binds CNTRF

Stable Identifier
R-HSA-5696490
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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On target cells ciliary neurotrophic factor (CNTF), and cardiotrophin-like cytokine factor 1 (CLCF1) first bind their specific ligand binding component, CNTF alpha-receptor (CNTFR) subunit and induce STAT3 phosphorylation (Elson et al. 2000, Lelievre et al. 2001). CNTFR then recruits glycoprotein (gp)130, and finally complexes with leukemia inhibitory factor receptor (LIFR) beta (Stahl & Yancopoulos 1994).

Literature References
PubMed ID Title Journal Year
10966616 CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex

Elson, GC, Lelièvre, E, Guillet, C, Chevalier, S, Plun-Favreau, H, Froger, J, Suard, I, de Coignac, AB, Delneste, Y, Bonnefoy, JY, Gauchat, JF, Gascan, H

Nat. Neurosci. 2000
21715184 Cytokine-like factor 1 (CLF1): life after development?

Kass, DJ

Cytokine 2011
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