CRLF1:CLCF1 binds CNTRF

Stable Identifier
R-HSA-5696490
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CRLF1:CLCF1 binds CNTRF
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

On target cells ciliary neurotrophic factor (CNTF), and cardiotrophin-like cytokine factor 1 (CLCF1) first bind their specific ligand binding component, CNTF alpha-receptor (CNTFR) subunit and induce STAT3 phosphorylation (Elson et al. 2000, Lelievre et al. 2001). CNTFR then recruits glycoprotein (gp)130, and finally complexes with leukemia inhibitory factor receptor (LIFR) beta (Stahl & Yancopoulos 1994).

Literature References
PubMed ID Title Journal Year
10966616 CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex

Elson, GC, Lelièvre, E, Guillet, C, Chevalier, S, Plun-Favreau, H, Froger, J, Suard, I, de Coignac, AB, Delneste, Y, Bonnefoy, JY, Gauchat, JF, Gascan, H

Nat. Neurosci. 2000
21715184 Cytokine-like factor 1 (CLF1): life after development?

Kass, DJ

Cytokine 2011
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
CRLF1:CLCF1 binds CNTRF (Bos taurus)
CRLF1:CLCF1 binds CNTRF (Canis familiaris)
CRLF1:CLCF1 binds CNTRF (Danio rerio)
CRLF1:CLCF1 binds CNTRF (Gallus gallus)
CRLF1:CLCF1 binds CNTRF (Mus musculus)
CRLF1:CLCF1 binds CNTRF (Rattus norvegicus)
CRLF1:CLCF1 binds CNTRF (Sus scrofa)
CRLF1:CLCF1 binds CNTRF (Xenopus tropicalis)
Authored
Garapati, P V  (2015-07-21)
Reviewed
Narazaki, M  (2015-11-09)
Tanaka, M  (2015-11-09)
Created
Garapati, P V  (2015-05-29)