IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)

Stable Identifier
R-HSA-449976
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
Synonyms
Interleukin-11 receptor alpha:Interleukin-11 binds Interleukin-6 receptor beta
ReviewStatus
5/5
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IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
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Interleukin-11 receptor alpha subunit (IL11RA) binds interleukin-11 (IL11) with low affinity but for high affinity binding and signaling must associate with interleukin-6 receptor beta subunit (IL6ST, gp130).

Literature References
PubMed ID Title Journal Year
7957045 Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction

Willson, TA, Nicola, NA, Harrison-Smith, M, Hilton, AA, Metcalf, D, Raicevic, A, Gough, NM, Rakar, S, Begley, CG, Hilton, DJ

EMBO J 1994
8637716 The human IL-11 receptor requires gp130 for signalling: demonstration by molecular cloning of the receptor

Nicola, N, Nandurkar, HH, Willson, T, Nathan, P, Begley, CG, Hilton, DJ

Oncogene 1996
Participants
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Output
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as an event of
Orthologous Events
IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Danio rerio)
IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Gallus gallus)
IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Mus musculus)
IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Rattus norvegicus)
IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Sus scrofa)
IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Xenopus tropicalis)
Authored
Jupe, S  (2009-12-07)
Reviewed
Tanaka, M  (2015-11-09)
Narazaki, M  (2015-11-09)
Created
Jupe, S  (2009-12-11)
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