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CHRM3 [plasma membrane]
Stable Identifier
R-HSA-399994
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Muscarinic Acetylcholine Receptor M3, M3
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Acetylcholine regulates insulin secretion (Homo sapiens)
Acetylcholine binds Muscarinic Acetylcholine Receptor M3 (Homo sapiens)
CHRM3 [plasma membrane] (Homo sapiens)
Muscarinic Acetylcholine Receptor M3:Acetylcholine Complex [plasma membrane] (Homo sapiens)
CHRM3 [plasma membrane] (Homo sapiens)
Muscarinic Acetylcholine Receptor M3 activates Gq (Homo sapiens)
Muscarinic Acetylcholine Receptor M3:Acetylcholine Complex [plasma membrane] (Homo sapiens)
CHRM3 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM3 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM3 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM3 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Muscarinic acetylcholine receptors (Homo sapiens)
CHRM1,3,5 bind CHRM1,3,5 antagonists (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM3 [plasma membrane] (Homo sapiens)
CHRM1,3,5:CHRM1,3,5 antagonists [plasma membrane] (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM3 [plasma membrane] (Homo sapiens)
CHRM1,3,5 bind acetylcholine (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM3 [plasma membrane] (Homo sapiens)
CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20309 CHRM3
Gene Names
CHRM3
Chain
chain:1-590
Reference Genes
BioGPS Gene:1131 CHRM3
COSMIC (genes):CHRM3 CHRM3
CTD Gene:1131 CHRM3
dbSNP Gene:1131 CHRM3
ENSEMBL:ENSG00000133019 CHRM3
HGNC:1952 CHRM3
KEGG Gene (Homo sapiens):1131 CHRM3
Monarch:1131 CHRM3
NCBI Gene:1131 CHRM3
OMIM:118494 CHRM3
UCSC:P20309 CHRM3
Reference Transcript
RefSeq:XM_017000153.1 CHRM3
RefSeq:XM_017000158.1 CHRM3
RefSeq:XM_017000160.1 CHRM3
RefSeq:NM_000740.3 CHRM3
RefSeq:XM_017000155.1 CHRM3
RefSeq:XM_005273032.3 CHRM3
RefSeq:XM_017000162.1 CHRM3
RefSeq:XM_011544043.2 CHRM3
RefSeq:XM_011544046.2 CHRM3
RefSeq:XM_017000154.1 CHRM3
RefSeq:XM_017000152.1 CHRM3
RefSeq:XM_017000156.1 CHRM3
RefSeq:XM_017000157.1 CHRM3
RefSeq:XM_017000159.1 CHRM3
RefSeq:XM_011544041.2 CHRM3
RefSeq:XM_011544044.2 CHRM3
RefSeq:XM_017000163.1 CHRM3
RefSeq:NM_001347716.1 CHRM3
RefSeq:XM_017000161.1 CHRM3
RefSeq:XM_011544047.2 CHRM3
Other Identifiers
0003520133
1131
11731806_a_at
1553705_PM_a_at
1553705_a_at
1559633_PM_a_at
1559633_a_at
1564339_PM_a_at
1564339_a_at
16679281
214596_PM_at
214596_at
2387607
2387619
2387626
2387629
2387630
2387631
2387647
2387666
2387667
2387668
2387669
2387670
2387671
2387695
2387704
2387705
2387706
2387708
242488_PM_at
242488_at
2488205
36759_at
42587_at
7910915
A_14_P121189
A_14_P125847
A_14_P135163
A_14_P201069
A_21_P0013981
A_23_P200843
A_23_P401472
A_24_P25137
A_24_P817236
GE59062
GE869207
GO:0003013
GO:0003056
GO:0003674
GO:0004435
GO:0004930
GO:0004993
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005783
GO:0005789
GO:0005886
GO:0005887
GO:0006464
GO:0006810
GO:0006939
GO:0007165
GO:0007186
GO:0007187
GO:0007197
GO:0007213
GO:0007267
GO:0007268
GO:0007271
GO:0007399
GO:0008150
GO:0009925
GO:0016020
GO:0016021
GO:0016323
GO:0016907
GO:0019722
GO:0030054
GO:0030425
GO:0030594
GO:0032412
GO:0038023
GO:0042166
GO:0043167
GO:0043226
GO:0045202
GO:0045211
GO:0045987
GO:0046541
GO:0048856
GO:0055085
GO:0095500
GO:0098664
HMNXSV003003293
HMNXSV003016403
Hs.140942.0.A1_3p_at
Hs.7138.0.S2_3p_at
Hs2.7138.1.S1_3p_s_at
Hs2.7138.3.S1_3p_s_at
ILMN_1672407
ILMN_1710410
ILMN_1720364
ILMN_1887357
ILMN_3248627
PH_hs_0030943
PH_hs_0034131
TC01005139.hg
TC01005141.hg
U29589_at
Participates
as an input of
Acetylcholine binds Muscarinic Acetylcholine Receptor M3 (Homo sapiens)
as a component of
Muscarinic Acetylcholine Receptor M3:Acetylcholine Complex [plasma membrane] (Homo sapiens)
as a member of
CHRM1,3,5 [plasma membrane] (Homo sapiens)
Inferred To
chrm3 [plasma membrane]
(Xenopus tropicalis)
gar-3 [plasma membrane]
(Caenorhabditis elegans)
chrm3a [plasma membrane]
(Danio rerio)
mAChR-A [plasma membrane]
(Drosophila melanogaster)
CHRM3 [plasma membrane]
(Bos taurus)
CHRM3 [plasma membrane]
(Canis familiaris)
CHRM3 [plasma membrane]
(Sus scrofa)
Chrm3 [plasma membrane]
(Mus musculus)
Chrm3 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_000731.1
,
XP_005273089.1
,
XP_016855650.1
,
XP_016855652.1
,
XP_011542349.1
,
XP_016855646.1
,
XP_016855642.1
,
XP_011542346.1
,
XP_011542345.1
,
NP_001334645.1
,
XP_016855644.1
,
XP_016855648.1
,
XP_011542343.1
,
XP_016855651.1
,
XP_016855643.1
,
XP_011542348.1
,
XP_016855649.1
,
XP_016855645.1
,
XP_016855641.1
,
XP_016855647.1
ZINC - World Drugs
ACM3_HUMAN
Guide to Pharmacology - Targets
15
OpenTargets
ENSG00000133019
ZINC - FDA approved
ACM3_HUMAN
ZINC - Substances
ACM3_HUMAN
ZINC target
P20309
ZINC - Biogenic
ACM3_HUMAN
PRO
P20309
PDB
2CSA
ZINC - Investigational
ACM3_HUMAN
ZINC - Metabolites
ACM3_HUMAN
HPA
ENSG00000133019-CHRM3
GeneCards
P20309
Ensembl
ENST00000615928
,
ENSP00000482377
,
ENST00000255380
,
ENSP00000502013
,
ENST00000675184
,
ENST00000676433
,
ENSP00000255380
,
ENSP00000502667
,
ENSP00000502349
,
ENSG00000133019
,
ENST00000676153
Pharos - Targets
P20309
Orphanet
21082
ZINC - Predictions - Purchasable
ACM3_HUMAN
HMDB Protein
HMDBP10807
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08912 CHRM5
1
CHRM5 [plasma membrane]
(R-HSA-390678)
0.589
7
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