Reactome | CHRM3 [plasma membrane]

CHRM3

Stable Identifier

R-HSA-399994

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Muscarinic Acetylcholine Receptor M3, M3

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM1, 3, 5 [plasma membrane] (Homo sapiens)
        
        CHRM3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM1, 3, 5 [plasma membrane] (Homo sapiens)
        
        CHRM3 [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM1, 3, 5 [plasma membrane] (Homo sapiens)
        
        CHRM3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM1, 3, 5 [plasma membrane] (Homo sapiens)
        
        CHRM3 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        CHRM1, 3, 5 [plasma membrane] (Homo sapiens)
        
        CHRM3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM1, 3, 5 [plasma membrane] (Homo sapiens)
        
        CHRM3 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Muscarinic acetylcholine receptors (Homo sapiens)
        
        M1, M3 and M5 receptors bind acetylcholine (Homo sapiens)
        
        CHRM1, 3, 5 [plasma membrane] (Homo sapiens)
        
        CHRM3 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM1, 3, 5 [plasma membrane] (Homo sapiens)
        
        CHRM3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P20309 CHRM3

Gene Names

CHRM3

Chain

chain:1-590

Reference Genes

BioGPS Gene:1131 CHRM3

COSMIC (genes):CHRM3 CHRM3

CTD Gene:1131 CHRM3

dbSNP Gene:1131 CHRM3

ENSEMBL:ENSG00000133019 CHRM3

HGNC:1952 CHRM3

KEGG Gene (Homo sapiens):hsa:1131 CHRM3

Monarch:1131 CHRM3

NCBI Gene:1131 CHRM3

OMIM:118494 CHRM3

UCSC:P20309 CHRM3

Reference Transcript

Other Identifiers

0003520133

1131

11731806_a_at

1553705_a_at

1559633_a_at

1564339_a_at

214596_at

2387629

2387630

2387631

2387647

2387666

2387667

2387668

2387669

2387670

2387671

2387704

2387705

2387706

2387708

24106

242488_at

2488205

2CSA

36759_at

42587_at

48036

7910915

A0A024R3S2

A_14_P121189

A_14_P125847

A_14_P135163

A_14_P201069

A_23_P200843

A_23_P401472

A_24_P25137

A_24_P817236

AAA70337

AAG30036

AAH96844

AAI21027

AAM18940

AB041395

AF279779

AF498917

AL356361

B1AN12

BAA94480

BC096844

BC121026

CAA33337

CCDS1616

CH471098

CHRM3

CHRM3-201

CHRM3-207

EAW70076

EAW70077

EAW70078

ENSG00000133019

ENSP00000255380

ENSP00000482377

ENST00000255380

ENST00000615928

EntrezGene:1131

GE59062

GE869207

GO:0003013

GO:0003056

GO:0003674

GO:0004435

GO:0004871

GO:0004930

GO:0005515

GO:0005575

GO:0005623

GO:0005886

GO:0005887

GO:0006464

GO:0006810

GO:0006939

GO:0007165

GO:0007186

GO:0007197

GO:0007207

GO:0007213

GO:0007267

GO:0007271

GO:0007399

GO:0008144

GO:0008150

GO:0008283

GO:0016020

GO:0016021

GO:0016323

GO:0016907

GO:0019229

GO:0030054

GO:0030425

GO:0032279

GO:0038023

GO:0042166

GO:0043167

GO:0043679

GO:0045202

GO:0045211

GO:0045987

GO:0046541

GO:0048856

HGNC:1952

HPA024106

HPA048036

Hs.140942.0.A1_3p_at

Hs.7138.0.S2_3p_at

Hs2.7138.1.S1_3p_s_at

Hs2.7138.3.S1_3p_s_at

ILMN_1710410

ILMN_1887357

ILMN_3248627

IPR000276

IPR000995

IPR001183

IPR017452

MIM:100100

MIM:118494

NM_000740

NP_000731

NP_001334645

PF00001

PH_hs_0030943

PH_hs_0034131

PR00237

PR00243

PR00540

SM01381

TC01005141.hg

U29589

U29589_at

uc001hyp.4

uc057qrc.1

UPI0000050453

X15266

XM_005273032

XM_011544041

XM_011544043

XM_011544044

XM_011544045

XM_011544046

XM_011544047

XM_017000152

XM_017000153

XM_017000154

XM_017000155

XM_017000156

XM_017000157

XM_017000158

XM_017000159

XM_017000160

XM_017000161

XM_017000162

XM_017000163

XP_005273089

XP_011542343

XP_011542345

XP_011542346

XP_011542347

XP_011542348

XP_011542349

XP_016855641

XP_016855642

XP_016855643

XP_016855644

XP_016855645

XP_016855646

XP_016855647

XP_016855648

XP_016855649

XP_016855650

XP_016855651

XP_016855652

Participant Of

hasMember

CHRM1, 3, 5 [plasma membrane]

input

Acetylcholine binds Muscarinic Acetylcholine Receptor M3

hasComponent

Muscarinic Acetylcholine Receptor M3:Acetylcholine Complex [plasma membrane]

Inferred To

Homologues of CHRM3 [plasma membrane] (Danio rerio)

CHRM3 [plasma membrane] (Bos taurus)

CHRM3 [plasma membrane] (Caenorhabditis elegans)

CHRM3 [plasma membrane] (Canis familiaris)

CHRM3 [plasma membrane] (Danio rerio)

CHRM3 [plasma membrane] (Drosophila melanogaster)

CHRM3 [plasma membrane] (Gallus gallus)

CHRM3 [plasma membrane] (Mus musculus)

CHRM3 [plasma membrane] (Rattus norvegicus)

CHRM3 [plasma membrane] (Sus scrofa)

CHRM3 [plasma membrane] (Taeniopygia guttata)

CHRM3 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

XP_011542346.1, XP_016855652.1, XP_016855641.1, XP_016855647.1, XP_011542348.1, XP_016855645.1, NP_001334645.1, XP_016855642.1, XP_016855648.1, XP_016855650.1, XP_016855646.1, XP_011542343.1, XP_016855649.1, NP_000731.1, XP_016855643.1, XP_011542345.1, XP_005273089.1, XP_016855651.1, XP_011542349.1, XP_016855644.1

ZINC - World Drugs

ACM3_HUMAN

ZINC - FDA approved

ACM3_HUMAN

ZINC - Substances

ACM3_HUMAN

ZINC - Biogenic

ACM3_HUMAN

ZINC target

P20309

PRO

P20309

PDB

2CSA

ZINC - Metabolites

ACM3_HUMAN

GeneCards

P20309

ZINC - Predictions - Purchasable

ACM3_HUMAN

Orphanet

21082

HMDB Protein

HMDBP10807