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VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol]
Stable Identifier
R-HSA-9948416
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Ribosome-associated quality control (Homo sapiens)
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide (Homo sapiens)
ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide (Homo sapiens)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol] (Homo sapiens)
VCP hexamer and NPLOC4:UFD1 bind K48polyubiquitin of LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide (Homo sapiens)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol] (Homo sapiens)
Participants
components
60S ribosomal complex [cytosol]
(Homo sapiens)
LTN1 [cytosol]
(Homo sapiens)
NEMF [cytosol]
(Homo sapiens)
NPLOC4 [cytosol]
(Homo sapiens)
peptidyl-tRNA with K48polyUb-nascent peptide-Alanine [cytosol]
(Homo sapiens)
TCF25 [cytosol]
(Homo sapiens)
UFD1 [cytosol]
(Homo sapiens)
VCP hexamer [cytosol]
(Homo sapiens)
Participates
as an input of
ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide (Homo sapiens)
as an output of
VCP hexamer and NPLOC4:UFD1 bind K48polyubiquitin of LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide (Homo sapiens)
Inferred To
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol]
(Bos taurus)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol]
(Caenorhabditis elegans)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol]
(Canis familiaris)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol]
(Danio rerio)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol]
(Dictyostelium discoideum)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol]
(Drosophila melanogaster)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol]
(Gallus gallus)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol]
(Mus musculus)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol]
(Plasmodium falciparum)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol]
(Rattus norvegicus)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol]
(Saccharomyces cerevisiae)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol]
(Schizosaccharomyces pombe)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol]
(Sus scrofa)
VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol]
(Xenopus tropicalis)
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