Reactome | ATG3 [cytosol]

ATG3 [cytosol]

Stable Identifier

R-HSA-5671860

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin-like-conjugating enzyme ATG3 ecNumber6.3.2.-/ecNumber, ATG3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NT62 ATG3

Gene Names

ATG3, APG3, APG3L

Chain

chain:1-314

Reference Genes

BioGPS Gene:64422 ATG3

COSMIC (genes):ATG3 ATG3

CTD Gene:64422 ATG3

dbSNP Gene:64422 ATG3

ENSEMBL:ENSG00000144848 ATG3

HGNC:20962 ATG3

KEGG Gene (Homo sapiens):64422 ATG3

Monarch:64422 ATG3

NCBI Gene:64422 ATG3

OMIM:609606 ATG3

UCSC:Q9NT62 ATG3

Reference Transcript

Other Identifiers

0002680369

11716100_a_at

11716101_s_at

11716102_x_at

11753924_a_at

11753925_x_at

11759680_a_at

16957372

220237_PM_at

220237_at

221492_PM_s_at

221492_s_at

2688763

2688764

2688765

2688766

2688767

2688768

2688769

2688773

2688775

2688776

2688778

2688780

2688781

2688782

2688786

2688788

2688789

2688790

2688791

2688792

64422

65839_at

8089527

A_23_P212706

A_24_P196382

GE56737

GO:0000045

GO:0000153

GO:0000422

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0006464

GO:0006605

GO:0006612

GO:0006810

GO:0006914

GO:0007005

GO:0008150

GO:0008219

GO:0009056

GO:0015031

GO:0016192

GO:0016236

GO:0016567

GO:0016740

GO:0019776

GO:0019777

GO:0019787

GO:0019899

GO:0022607

GO:0032991

GO:0043653

GO:0044804

GO:0050765

GO:1902017

HMNXSV003006789

ILMN_1769566

ILMN_2163732

PH_hs_0002324

TC03001650.hg

g11493699_3p_a_at

g11968042_3p_a_at

g11968042_3p_x_at

Participates

as an input of

LC3:ATG7 dimer binds ATG3 (Homo sapiens)

as a component of

LC3:CysO572-ATG7:ATG7:ATG3 [cytosol] (Homo sapiens)

as an output of

ATG16L1 complex transfers LC3 from ATG3 to PE (Homo sapiens)

Other forms of this molecule

CysO263-ATG3 [cytosol]

Inferred To

Homologues of ATG3 [cytosol] (Plasmodium falciparum)

atg-3 [cytosol] (Caenorhabditis elegans)

atg3 [cytosol] (Danio rerio)

atg3 [cytosol] (Dictyostelium discoideum)

atg3 [cytosol] (Schizosaccharomyces pombe)

atg3 [cytosol] (Xenopus tropicalis)

ATG3 [cytosol] (Bos taurus)

ATG3 [cytosol] (Canis familiaris)

ATG3 [cytosol] (Gallus gallus)

ATG3 [cytosol] (Plasmodium falciparum)

ATG3 [cytosol] (Saccharomyces cerevisiae)

ATG3 [cytosol] (Sus scrofa)

Atg3 [cytosol] (Drosophila melanogaster)

Atg3 [cytosol] (Mus musculus)

Atg3 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_071933.2, NP_001265641.1

OpenTargets

ENSG00000144848

HPA

ENSG00000144848-ATG3

GeneCards

Q9NT62

Ensembl

ENSP00000283290, ENSG00000144848, ENST00000283290, ENST00000402314, ENSP00000385943

PRO

Q9NT62

Pharos - Targets

Q9NT62

PDB

4NAW

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O94817 ATG12	2	ATG12 [cytosol] (R-HSA-936011) ATG12 [phagocytic vesicle membrane] (R-HSA-5205625)	0.815	7
UniProt:P60520 GABARAPL2	3	GABARAPL2 [cytosol] (R-HSA-5671758) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [autophagosome membrane] (R-HSA-5683633)	0.75	6
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651)	0.743	7
UniProt:O95166 GABARAP	3	GABARAP [autophagosome membrane] (R-HSA-5683634) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [cytosol] (R-HSA-975521)	0.667	5
UniProt:Q70IA6 MOB2			0.556	3
UniProt:P62879 GNB2	4	GNB2 [plasma membrane] (R-HSA-164335) Unfolded GNB2 [cytosol] (R-HSA-6814202) Partially folded GNB2 [cytosol] (R-HSA-8850536) GNB2 [cytosol] (R-HSA-6814421)	0.556	3
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [cytosol] (R-HSA-5671757) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [autophagosome membrane] (R-HSA-5683637)	0.525	3
UniProt:Q7Z6L1 TCPR1			0.499	3

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