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CysO264-ATG3-MAP1LC3A [cytosol]
Stable Identifier
R-HSA-9819371
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ATG3-MAP1LC3A conjugate
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
ATG16L1 complex transfers LC3 from ATG3 to PE (Homo sapiens)
CysO264-ATG3-LC3 [cytosol] (Homo sapiens)
CysO264-ATG3-MAP1LC3A [cytosol] (Homo sapiens)
ATG3 transfers LC3 from ATG7 to ATG3 (Homo sapiens)
CysO264-ATG3-LC3:ATG7 dimer [cytosol] (Homo sapiens)
CysO264-ATG3-LC3 [cytosol] (Homo sapiens)
CysO264-ATG3-MAP1LC3A [cytosol] (Homo sapiens)
ATG7:ATG3:LC3 dissociates (Homo sapiens)
CysO264-ATG3-LC3 [cytosol] (Homo sapiens)
CysO264-ATG3-MAP1LC3A [cytosol] (Homo sapiens)
CysO264-ATG3-LC3:ATG7 dimer [cytosol] (Homo sapiens)
CysO264-ATG3-LC3 [cytosol] (Homo sapiens)
CysO264-ATG3-MAP1LC3A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NT62 ATG3
Gene Names
ATG3, APG3, APG3L
Chain
chain:1-314
Reference Genes
BioGPS Gene:64422 ATG3
COSMIC (genes):ATG3 ATG3
CTD Gene:64422 ATG3
dbSNP Gene:64422 ATG3
ENSEMBL:ENSG00000144848 ATG3
ENSEMBL_homo_sapiens_GENE:ENSG00000144848.11 ATG3
HGNC:20962 ATG3
KEGG Gene (Homo sapiens):64422 ATG3
Monarch:64422 ATG3
NCBI Gene:64422 ATG3
OMIM:609606 ATG3
UCSC:Q9NT62 ATG3
Reference Transcript
RefSeq:NM_001278712.1 ATG3
RefSeq:NM_022488.4 ATG3
Other Identifiers
11716100_a_at
11716101_s_at
11716102_x_at
11753924_a_at
11753925_x_at
11759680_a_at
16957372
220237_PM_at
220237_at
221492_PM_s_at
221492_s_at
2688763
2688764
2688765
2688766
2688767
2688768
2688769
2688773
2688775
2688776
2688778
2688780
2688781
2688782
2688786
2688788
2688789
2688790
2688791
2688792
64422
65839_at
8089527
A_23_P212706
A_24_P196382
GE56737
GO:0000045
GO:0000407
GO:0003824
GO:0005515
GO:0005737
GO:0005829
GO:0006612
GO:0006886
GO:0006914
GO:0007005
GO:0012501
GO:0015031
GO:0016192
GO:0016236
GO:0016567
GO:0016740
GO:0019776
GO:0019777
GO:0019787
GO:0019899
GO:0034274
GO:0036211
GO:0043653
GO:0044782
GO:0044804
GO:0050765
GO:0140096
GO:0141046
GO:1902017
HMNXSV003006789
ILMN_1769566
ILMN_2163732
PH_hs_0002324
TC03001650.hg
g11493699_3p_a_at
g11968042_3p_a_at
g11968042_3p_x_at
Participates
as a member of
CysO264-ATG3-LC3 [cytosol] (Homo sapiens)
Other forms of this molecule
ATG3 [cytosol]
CysO264-ATG3-GABARAP [cytosol]
CysO264-ATG3-GABARAPL3 [cytosol]
CysO264-ATG3-MAP1LC3B [cytosol]
CysO264-ATG3-GABARAPL1 [cytosol]
CysO264-ATG3-MAP1LC3C [cytosol]
CysO264-ATG3-GABARAPL2 [cytosol]
Inferred To
CysO264-ATG3-MAP1LC3A [cytosol]
(Gallus gallus)
CysO264-ATG3-MAP1LC3A [cytosol]
(Plasmodium falciparum)
CysO264-ATG3-MAP1LC3A [cytosol]
(Saccharomyces cerevisiae)
CysO264-ATG3-MAP1LC3A [cytosol]
(Schizosaccharomyces pombe)
CysO264-ATG3-MAP1LC3A [cytosol]
(Sus scrofa)
Homologues of CysO264-ATG3-MAP1LC3A [cytosol]
(Plasmodium falciparum)
atg-3 [cytosol]
(Caenorhabditis elegans)
atg3 [cytosol]
(Danio rerio)
atg3 [cytosol]
(Dictyostelium discoideum)
atg3 [cytosol]
(Xenopus tropicalis)
ATG3 [cytosol]
(Bos taurus)
ATG3 [cytosol]
(Canis familiaris)
Atg3 [cytosol]
(Drosophila melanogaster)
Atg3 [cytosol]
(Mus musculus)
Atg3 [cytosol]
(Rattus norvegicus)
Modified Residues
Name
Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 264 and 120
Coordinate
264
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Cross References
RefSeq
NP_001265641.1
,
NP_071933.2
OpenTargets
ENSG00000144848
HPA
ENSG00000144848-ATG3
GeneCards
Q9NT62
Ensembl
ENSP00000283290
,
ENST00000283290
,
ENSP00000385943
,
ENSG00000144848
,
ENST00000402314
PRO
Q9NT62
Pharos - Targets
Q9NT62
PDB
8AFI
,
4NAW
,
8FKM
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O94817 ATG12
2
ATG12 [phagocytic vesicle membrane]
(R-HSA-5205625)
ATG12 [cytosol]
(R-HSA-936011)
0.894
10
UniProt:P60520 GABARAPL2
3
GABARAPL2 [autophagosome membrane]
(R-HSA-5683633)
GABARAPL2(1-117) [cytosol]
(R-HSA-5682641)
GABARAPL2 [cytosol]
(R-HSA-5671758)
0.85
8
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [cytosol]
(R-HSA-5205651)
0.8
8
UniProt:O95166 GABARAP
3
GABARAP [autophagosome membrane]
(R-HSA-5683634)
GABARAP(1-117) [cytosol]
(R-HSA-5682696)
GABARAP [cytosol]
(R-HSA-975521)
0.667
5
UniProt:Q9H1Y0 ATG5
3
ATG5 [phagocytic vesicle membrane]
(R-HSA-5205636)
GlyK130-ATG5 [cytosol]
(R-HSA-5683582)
ATG5 [cytosol]
(R-HSA-936010)
0.643
5
UniProt:Q676U5 ATG16L1
1
ATG16L1 [cytosol]
(R-HSA-5671734)
0.643
3
UniProt:Q70IA6 MOB2
0.556
3
UniProt:P62879 GNB2
4
GNB2 [cytosol]
(R-HSA-6814421)
Partially folded GNB2 [cytosol]
(R-HSA-8850536)
Unfolded GNB2 [cytosol]
(R-HSA-6814202)
GNB2 [plasma membrane]
(R-HSA-164335)
0.556
3
UniProt:O95352 ATG7
14
ATG7 [secretory granule lumen]
(R-HSA-6801316)
ATG7 [extracellular region]
(R-HSA-6806451)
ATG7 [ficolin-1-rich granule lumen]
(R-HSA-6801293)
ATG7(1-693)-BRAF(381-766) fusion [cytosol]
(R-HSA-6802272)
ATG7(1-693)-p-BRAF(381-766) fusion [cytosol]
(R-HSA-6802517)
CysO572-ATG7-MAP1LC3B [cytosol]
(R-HSA-9820410)
CysO572-ATG7-GARABAPL2 [cytosol]
(R-HSA-9820413)
CysO572-ATG7-GARABAP [cytosol]
(R-HSA-9820417)
CysO572-ATG7-GARABAPL1 [cytosol]
(R-HSA-9820406)
CysO572-ATG7-MAP1LC3C [cytosol]
(R-HSA-9820407)
CysO572-ATG7-MAP1LC3A [cytosol]
(R-HSA-9820421)
CysO572-ATG7-GARABAPL3 [cytosol]
(R-HSA-9820420)
CysO572-ATG7 [cytosol]
(R-HSA-5683584)
ATG7 [cytosol]
(R-HSA-947867)
0.527
4
UniProt:A6NCE7 MP3B2
0.527
3
UniProt:Q9H0R8 GABARAPL1
3
GABARAPL1 [autophagosome membrane]
(R-HSA-5683637)
GABARAPL1(1-117) [cytosol]
(R-HSA-5682659)
GABARAPL1 [cytosol]
(R-HSA-5671757)
0.525
3
UniProt:Q7Z6L1 TCPR1
0.499
3
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