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ub-pS-GLI1 [ciliary base]
Stable Identifier
R-HSA-5610514
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ciliary base
Synonyms
PKA-phosphorylated GLI1, Zinc finger protein GLI1, GLI1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
Degradation of GLI1 by the proteasome (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Homo sapiens)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Homo sapiens)
ub-pS-GLI1 [ciliary base] (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Homo sapiens)
ub-pS-GLI1:SUFU [ciliary base] (Homo sapiens)
ub-pS-GLI1 [ciliary base] (Homo sapiens)
NUMB:ITCH bind and ubiquitnate GLI1 (Homo sapiens)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Homo sapiens)
ub-pS-GLI1 [ciliary base] (Homo sapiens)
SCF(beta-TrCP) ubiquitinates p-GLI1 (Homo sapiens)
ub-pS-GLI1:SUFU [ciliary base] (Homo sapiens)
ub-pS-GLI1 [ciliary base] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08151 GLI1
Gene Names
GLI1, GLI
Chain
chain:1-1106
Reference Genes
BioGPS Gene:2735 GLI1
COSMIC (genes):GLI1 GLI1
CTD Gene:2735 GLI1
dbSNP Gene:2735 GLI1
ENSEMBL:ENSG00000111087 GLI1
ENSEMBL:ENSG00000111087.10 GLI1
HGNC:4317 GLI1
KEGG Gene (Homo sapiens):2735 GLI1
Monarch:2735 GLI1
NCBI Gene:2735 GLI1
OMIM:165220 GLI1
UCSC:P08151 GLI1
Reference Transcript
RefSeq:NM_001167609.1 GLI1
RefSeq:NM_001160045.1 GLI1
RefSeq:XM_011538189.2 GLI1
RefSeq:NM_005269.2 GLI1
Other Identifiers
11729427_a_at
16752888
206646_PM_at
206646_at
2735
33474_at
3418119
3418121
3418123
3418124
3418125
3418126
3418127
3418129
3418130
3418131
3418132
3418133
3418134
3418135
3418136
3418137
3418138
3418139
3418140
3418141
3418142
3418143
3418144
3418145
3418146
3418147
3418148
7956430
A_14_P120578
A_23_P105251
GE59693
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0001228
GO:0001649
GO:0003677
GO:0003682
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005929
GO:0005930
GO:0006260
GO:0006351
GO:0006355
GO:0006357
GO:0007224
GO:0007283
GO:0007286
GO:0007418
GO:0008017
GO:0008092
GO:0008284
GO:0008589
GO:0009611
GO:0009913
GO:0009953
GO:0009954
GO:0021696
GO:0021938
GO:0021983
GO:0022414
GO:0023052
GO:0030154
GO:0030324
GO:0030335
GO:0030850
GO:0043226
GO:0043565
GO:0045667
GO:0045740
GO:0045880
GO:0045893
GO:0045944
GO:0046872
GO:0048546
GO:0048856
GO:0048870
GO:0060032
GO:0060045
GO:0090090
GO:0097421
GO:0097542
GO:0097546
GO:0140110
GO:1902808
GO:1990787
GO:1990788
GO:2000345
HMNXSV003000515
ILMN_1779989
PH_hs_0025490
TC12000530.hg
X07384_at
g4885278_3p_at
Participates
as a component of
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Homo sapiens)
ub-pS-GLI1:SUFU [ciliary base] (Homo sapiens)
Other forms of this molecule
pS-GLI1 [ciliary base]
ub-GLI1 [cytosol]
GLI1 [cytosol]
p-GLI1 [ciliary tip]
2p-GLI1 [nucleoplasm]
p-GLI1 [nucleoplasm]
GLI1 [ciliary tip]
GLI1 [ciliary base]
Inferred To
phospho-ub-pS-GLI1 [ciliary base]
(Canis familiaris)
phospho-ub-pS-GLI1 [ciliary base]
(Danio rerio)
phospho-ub-pS-GLI1 [ciliary base]
(Gallus gallus)
phospho-Gli1 [ciliary base]
(Mus musculus)
phospho-Gli1 [ciliary base]
(Rattus norvegicus)
phospho-ci [ciliary base]
(Drosophila melanogaster)
phospho-gli1 [ciliary base]
(Xenopus tropicalis)
phospho-GLI1 [ciliary base]
(Bos taurus)
phospho-GLI1 [ciliary base]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine at unknown position
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001161081.1
,
XP_011536491.1
,
NP_001153517.1
,
NP_005260.1
OpenTargets
ENSG00000111087
ZINC - Substances
GLI1_HUMAN
ZINC - Biogenic
GLI1_HUMAN
ZINC target
P08151
PRO
P08151
PDB
4BLB
,
5OM0
,
4KMD
,
7T91
,
2GLI
HPA
ENSG00000111087-GLI1
GeneCards
P08151
Ensembl
ENST00000228682
,
ENSP00000437607
,
ENST00000546141
,
ENSP00000228682
,
ENSG00000111087
,
ENST00000543426
,
ENST00000528467
,
ENSP00000441006
,
ENSP00000434408
Pharos - Targets
P08151
ZINC - Predictions - Purchasable
GLI1_HUMAN
Orphanet
26044
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UMX1 SUFU
3
SUFU [ciliary base]
(R-HSA-5610424)
SUFU [cytosol]
(R-HSA-445455)
SUFU [ciliary tip]
(R-HSA-5610426)
0.968
27
UniProt:Q9QZS3-2 NUMB
0.611
4
UniProt:Q96J02 ITCH
2
Ub-C871-ITCH [cytosol]
(R-HSA-8864515)
ITCH [cytosol]
(R-HSA-975995)
0.602
4
UniProt:Q9UMX1-2 SUFU
0.571
4
UniProt:Q96CN9 GCC1
1
GCC1 [cytosol]
(R-HSA-6813877)
0.556
3
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.556
3
UniProt:Q13526 PIN1
2
PIN1 [cytosol]
(R-HSA-9626823)
PIN1 [nucleoplasm]
(R-HSA-936016)
0.556
3
UniProt:Q8IWZ5 TRI42
0.556
3
UniProt:P29972 AQP1
1
AQP1 [plasma membrane]
(R-HSA-431700)
0.556
3
UniProt:P53673 CRBA4
0.556
3
UniProt:Q8NEC5 CATSPER1
1
CATSPER1 [plasma membrane]
(R-HSA-2534335)
0.556
3
UniProt:P23443-2 RPS6KB1
0.544
2
UniProt:Q9NRP7 STK36
0.536
2
UniProt:P46684 ZIC1
0.524
2
UniProt:P40337 VHL
3
monoSUMO1-K159,171,196-VHL [nucleoplasm]
(R-HSA-4551697)
VHL [nucleoplasm]
(R-HSA-1234127)
VHL [cytosol]
(R-HSA-391423)
0.463
2
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