Reactome | LIPT1 [mitochondrial matrix]

LIPT1 [mitochondrial matrix]

Stable Identifier

R-HSA-6792623

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Lipoyltransferase 1, mitochondrial ecNumber2.3.1.-/ecNumber, LIPT_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y234 LIPT1

Gene Names

LIPT1

Chain

transit peptide:1-25, chain:26-373

Reference Genes

BioGPS Gene:51601 LIPT1

COSMIC (genes):LIPT1 LIPT1

CTD Gene:51601 LIPT1

dbSNP Gene:51601 LIPT1

ENSEMBL:ENSG00000144182 LIPT1

ENSEMBL_homo_sapiens_GENE:ENSG00000144182.17 LIPT1

HGNC:29569 LIPT1

KEGG Gene (Homo sapiens):51601 LIPT1

Monarch:51601 LIPT1

NCBI Gene:51601 LIPT1

OMIM:610284 LIPT1

UCSC:Q9Y234 LIPT1

Reference Transcript

Other Identifiers

11727709_s_at

205571_PM_at

205571_at

2495781

2495783

2495787

2495790

2495791

2495792

2495793

2495794

2495795

2495796

2495797

37441_at

4117891

51601

8043840

A_14_P117300

A_23_P501805

GE53428

GO:0003824

GO:0005515

GO:0005737

GO:0005739

GO:0005759

GO:0006629

GO:0009249

GO:0016740

GO:0016746

GO:0017118

GO:0019752

GO:0036211

GO:0043226

GO:0051604

HMNXSV003040804

ILMN_1717524

ILMN_2343105

PH_hs_0006157

TC02003430.hg

g7706251_3p_at

Inferred To

Lipt1 [mitochondrial matrix] (Drosophila melanogaster)

Lipt1 [mitochondrial matrix] (Rattus norvegicus)

lipt-1 [mitochondrial matrix] (Caenorhabditis elegans)

lipt1 [mitochondrial matrix] (Danio rerio)

lipt1 [mitochondrial matrix] (Xenopus tropicalis)

LIPT1 [mitochondrial matrix] (Bos taurus)

LIPT1 [mitochondrial matrix] (Canis familiaris)

LIPT1 [mitochondrial matrix] (Dictyostelium discoideum)

LIPT1 [mitochondrial matrix] (Gallus gallus)

LIPT1 [mitochondrial matrix] (Mus musculus)

LIPT1 [mitochondrial matrix] (Plasmodium falciparum)

LIPT1 [mitochondrial matrix] (Saccharomyces cerevisiae)

LIPT1 [mitochondrial matrix] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_057013.1, NP_660199.1, NP_660200.1, NP_001191759.1, NP_660198.1

OpenTargets

ENSG00000144182

HPA

ENSG00000144182-LIPT1

GeneCards

Q9Y234

Ensembl

ENSG00000144182, ENSP00000377114, ENSP00000498546, ENSP00000377115, ENST00000393471, ENST00000651691, ENST00000393473

PRO

Q9Y234

Pharos - Targets

Q9Y234

Orphanet

22657

HMDB Protein

HMDBP10680

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17252 PRKCA	8	PRKCA [nucleoplasm] (R-HSA-450530) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292) PRKCA [plasma membrane] (R-HSA-156469)	0.666	4
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:Q15047-2 SETDB1			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:Q8TAP4-4 LMO3			0.556	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.556	3
UniProt:A6NJ78 MET15			0.527	2
UniProt:Q8IWV7 UBR1	1	UBR1 [cytosol] (R-HSA-976040)	0.527	2
UniProt:Q9UMX1 SUFU	3	SUFU [ciliary base] (R-HSA-5610424) SUFU [cytosol] (R-HSA-445455) SUFU [ciliary tip] (R-HSA-5610426)	0.527	2
UniProt:P52630 STAT2	4	p-Y690-STAT2 [cytosol] (R-HSA-909683) STAT2 [cytosol] (R-HSA-882029) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673) p-Y-STAT2 [cytosol] (R-HSA-8987235)	0.527	2
UniProt:P11182 DBT	7	Lipo-K105-DBT [mitochondrial matrix] (R-HSA-70017) Isobutyryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859151) Isovaleryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859144) 2-Methylbutyryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859145) LipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859167) DBT [mitochondrial matrix] (R-HSA-6792584) DBT [cytosol] (R-HSA-9714663)	0.527	3

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