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Su(fu) [ciliary base]
Stable Identifier
R-DME-5610424
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
ciliary base
Synonyms
SUFU, Q9VG38
Locations in the PathwayBrowser
Expand all
Signal Transduction (Drosophila melanogaster)
Signaling by Hedgehog (Drosophila melanogaster)
Hedgehog 'off' state (Drosophila melanogaster)
Degradation of GLI1 by the proteasome (Drosophila melanogaster)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Drosophila melanogaster)
ub-pS-GLI1:SUFU [ciliary base] (Drosophila melanogaster)
Su(fu) [ciliary base] (Drosophila melanogaster)
SCF(beta-TrCP) ubiquitinates p-GLI1 (Drosophila melanogaster)
pS-GLI1:SUFU [ciliary base] (Drosophila melanogaster)
Su(fu) [ciliary base] (Drosophila melanogaster)
ub-pS-GLI1:SUFU [ciliary base] (Drosophila melanogaster)
Su(fu) [ciliary base] (Drosophila melanogaster)
GLI3 is processed to GLI3R by the proteasome (Drosophila melanogaster)
CK1 phosphorylates p-GLI3 (Drosophila melanogaster)
p10S-GLI3:SUFU [ciliary base] (Drosophila melanogaster)
Su(fu) [ciliary base] (Drosophila melanogaster)
p6S-GLI3:SUFU [ciliary base] (Drosophila melanogaster)
Su(fu) [ciliary base] (Drosophila melanogaster)
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Drosophila melanogaster)
4xub-p13S-Gli3:SUFU [ciliary base] (Drosophila melanogaster)
Su(fu) [ciliary base] (Drosophila melanogaster)
GSK3 phosphorylates p-GLI3 (Drosophila melanogaster)
p10S-GLI3:SUFU [ciliary base] (Drosophila melanogaster)
Su(fu) [ciliary base] (Drosophila melanogaster)
p13S-GLI3:SUFU [ciliary base] (Drosophila melanogaster)
Su(fu) [ciliary base] (Drosophila melanogaster)
PKA phosphorylates GLI3 (Drosophila melanogaster)
GLI3:SUFU [ciliary base] (Drosophila melanogaster)
Su(fu) [ciliary base] (Drosophila melanogaster)
p6S-GLI3:SUFU [ciliary base] (Drosophila melanogaster)
Su(fu) [ciliary base] (Drosophila melanogaster)
SCF(beta-TrCP) ubiquitinates p-GLI3 (Drosophila melanogaster)
4xub-p13S-Gli3:SUFU [ciliary base] (Drosophila melanogaster)
Su(fu) [ciliary base] (Drosophila melanogaster)
p13S-GLI3:SUFU [ciliary base] (Drosophila melanogaster)
Su(fu) [ciliary base] (Drosophila melanogaster)
The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Drosophila melanogaster)
GLI:SUFU [ciliary base] (Drosophila melanogaster)
Su(fu) [ciliary base] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VG38
Gene Names
Su(fu)
Reference Genes
BioGPS Gene:41565 Su(fu)
ENSEMBL:FBgn0005355
FlyBase:FBgn0005355
KEGG:dme:Dmel_CG6054 Su(fu)
Monarch:41565 Su(fu)
NCBI Gene:41565 Su(fu)
UCSC:Q9VG38 Su(fu)
Reference Transcript
RefSeq:NM_080502.5 Su(fu)
Other Identifiers
153324_at
1638427_at
41565
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0008134
GO:0008139
GO:0032991
GO:0045879
GO:0046823
GO:0051220
GO:0061629
GO:0140297
GO:0140313
Participates
as a component of
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Drosophila melanogaster)
pS-GLI1:SUFU [ciliary base] (Drosophila melanogaster)
ub-pS-GLI1:SUFU [ciliary base] (Drosophila melanogaster)
GLI:SUFU [ciliary base] (Drosophila melanogaster)
GLI3:SUFU [ciliary base] (Drosophila melanogaster)
p6S-GLI3:SUFU [ciliary base] (Drosophila melanogaster)
p10S-GLI3:SUFU [ciliary base] (Drosophila melanogaster)
p13S-GLI3:SUFU [ciliary base] (Drosophila melanogaster)
4xub-p13S-Gli3:SUFU [ciliary base] (Drosophila melanogaster)
Other forms of this molecule
Su(fu) [ciliary tip]
Su(fu) [cytosol]
Inferred From
SUFU [ciliary base]
(Homo sapiens)
Cross References
RefSeq
NP_536750.2
FlyBase
FBgn0005355
PDB
6LPH
,
4KMA
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19538 ci
20
CI [nucleoplasm]
(R-DME-205911)
CI75 [nucleoplasm]
(R-DME-205741)
CI75 [cytosol]
(R-DME-206171)
CI [cytosol]
(R-DME-206046)
Phospho (3 sites) CI [cytosol]
(R-DME-205938)
Phospho (11 sites) CI [cytosol]
(R-DME-205757)
Phospho (13 sites) CI [cytosol]
(R-DME-205801)
Phospho (16 sites) CI [cytosol]
(R-DME-206294)
ci [nucleoplasm]
(R-DME-5610371)
ci [cytosol]
(R-DME-5610369)
phospho-ci [ciliary base]
(R-DME-5610506)
phospho-ci [ciliary base]
(R-DME-5610485)
phospho-ci [ciliary base]
(R-DME-5610454)
phospho-ci [ciliary base]
(R-DME-5610492)
ci [ciliary base]
(R-DME-5610365)
ci [ciliary tip]
(R-DME-5610367)
ci [ciliary tip]
(R-DME-5610360)
ci [ciliary tip]
(R-DME-5610363)
ci [ciliary base]
(R-DME-5610357)
ci [ciliary base]
(R-DME-5610361)
0.764
5
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