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p13S-GLI3 [ciliary base]
Stable Identifier
R-HSA-5610485
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ciliary base
Synonyms
Gli3, PKA, CK1, GSK3-phosphorylated GLI3
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
GLI3 is processed to GLI3R by the proteasome (Homo sapiens)
GSK3 phosphorylates p-GLI3 (Homo sapiens)
p13S-GLI3:SUFU [ciliary base] (Homo sapiens)
p13S-GLI3 [ciliary base] (Homo sapiens)
SCF(beta-TrCP) ubiquitinates p-GLI3 (Homo sapiens)
p13S-GLI3:SUFU [ciliary base] (Homo sapiens)
p13S-GLI3 [ciliary base] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
16705181
Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP
Tempe, D
,
Concordet, JP
,
Casas, M
,
Blanchet-Tournier, MF
,
Karaz, S
Mol Cell Biol
2006
16371461
Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing
Wang, B
,
Li, Y
Proc. Natl. Acad. Sci. U.S.A.
2006
External Reference Information
External Reference
UniProt:P10071 GLI3
Gene Names
GLI3
Chain
chain:1-1580, chain:1-
Reference Genes
BioGPS Gene:2737 GLI3
COSMIC (genes):GLI3 GLI3
CTD Gene:2737 GLI3
dbSNP Gene:2737 GLI3
ENSEMBL:ENSG00000106571 GLI3
ENSEMBL_homo_sapiens_GENE:ENSG00000106571.15 GLI3
HGNC:4319 GLI3
KEGG Gene (Homo sapiens):2737 GLI3
Monarch:2737 GLI3
NCBI Gene:2737 GLI3
OMIM:165240 GLI3
UCSC:P10071 GLI3
Reference Transcript
RefSeq:NM_000168.5 GLI3
Other Identifiers
11723374_at
11723375_a_at
17056992
205201_PM_at
205201_at
227376_PM_at
227376_at
2737
3047699
3047700
3047701
3047702
3047703
3047704
3047706
3047708
3047709
3047721
3047725
3047727
3047728
3047730
3047733
3047734
3047741
3047742
3047762
3047763
3047781
3047782
3047783
3047784
3047788
40358_at
59780_s_at
60798_at
8139212
A_23_P111531
A_33_P3290562
GE57983
GO:0000122
GO:0000977
GO:0000978
GO:0000981
GO:0001649
GO:0001656
GO:0001658
GO:0001701
GO:0001822
GO:0002052
GO:0002062
GO:0002376
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0005856
GO:0005929
GO:0005930
GO:0006351
GO:0006355
GO:0006357
GO:0006606
GO:0006886
GO:0006913
GO:0006915
GO:0007155
GO:0007224
GO:0007389
GO:0007405
GO:0007411
GO:0007417
GO:0007420
GO:0007442
GO:0007507
GO:0008013
GO:0008283
GO:0008285
GO:0008589
GO:0009952
GO:0009953
GO:0009954
GO:0010467
GO:0010468
GO:0012501
GO:0016485
GO:0016607
GO:0017053
GO:0021513
GO:0021522
GO:0021537
GO:0021543
GO:0021544
GO:0021631
GO:0021766
GO:0021775
GO:0021776
GO:0021798
GO:0021801
GO:0021819
GO:0021861
GO:0021915
GO:0022018
GO:0023052
GO:0030154
GO:0030182
GO:0030318
GO:0030324
GO:0030326
GO:0030879
GO:0030900
GO:0032331
GO:0032332
GO:0033077
GO:0035035
GO:0035108
GO:0035295
GO:0036033
GO:0042127
GO:0042307
GO:0042475
GO:0042733
GO:0042826
GO:0042981
GO:0042995
GO:0043010
GO:0043066
GO:0043226
GO:0043231
GO:0043565
GO:0043585
GO:0043586
GO:0045060
GO:0045595
GO:0045665
GO:0045669
GO:0045879
GO:0045892
GO:0045893
GO:0045944
GO:0046632
GO:0046638
GO:0046639
GO:0046872
GO:0048557
GO:0048566
GO:0048589
GO:0048593
GO:0048598
GO:0048646
GO:0048663
GO:0048702
GO:0048704
GO:0048709
GO:0048754
GO:0048839
GO:0048856
GO:0048870
GO:0051604
GO:0060021
GO:0060173
GO:0060364
GO:0060366
GO:0060367
GO:0060594
GO:0060831
GO:0060840
GO:0060873
GO:0060875
GO:0061005
GO:0070242
GO:0071625
GO:0072089
GO:0090090
GO:0097542
GO:0097546
GO:0120223
GO:0140110
GO:1903010
GO:1990788
GO:1990837
GO:2000647
HMNXSV003038974
Hs.21509.0.A1_3p_at
ILMN_1771962
M57609_at
PH_hs_0004188
TC07001319.hg
g13518031_3p_at
Participates
as a component of
p13S-GLI3:SUFU [ciliary base] (Homo sapiens)
Other forms of this molecule
ub-2p-GLI3 [nucleoplasm]
GLI3 [cytosol]
p-GLI3 [ciliary tip]
2p-GLI3 [nucleoplasm]
p-GLI3 [nucleoplasm]
GLI3 [ciliary tip]
GLI3R [nucleoplasm]
GLI3R [cytosol]
ub-p13S-GLI3 [ciliary base]
p10S-GLI3 [ciliary base]
p6S-GLI3 [ciliary base]
GLI3 [ciliary base]
Inferred To
phospho-Gli3 [ciliary base]
(Mus musculus)
phospho-Gli3 [ciliary base]
(Rattus norvegicus)
phospho-gli3 [ciliary base]
(Danio rerio)
phospho-gli3 [ciliary base]
(Xenopus tropicalis)
phospho-GLI3 [ciliary base]
(Bos taurus)
phospho-GLI3 [ciliary base]
(Canis familiaris)
phospho-GLI3 [ciliary base]
(Sus scrofa)
phospho-ci [ciliary base]
(Drosophila melanogaster)
phospho-p13S-GLI3 [ciliary base]
(Gallus gallus)
Modified Residues
Name
O-phospho-L-serine at 849
Coordinate
849
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 865
Coordinate
865
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 877
Coordinate
877
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 907
Coordinate
907
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 980
Coordinate
980
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1006
Coordinate
1006
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_000159.3
OpenTargets
ENSG00000106571
HPA
ENSG00000106571-GLI3
GeneCards
P10071
Ensembl
ENSP00000502957
,
ENSG00000106571
,
ENST00000677605
,
ENST00000678429
,
ENSP00000503743
,
ENSP00000379258
,
ENST00000395925
PRO
P10071
Pharos - Targets
P10071
Orphanet
16139
PDB
4BLD
HMDB Protein
HMDBP02644
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UMX1 SUFU
3
SUFU [ciliary base]
(R-HSA-5610424)
SUFU [cytosol]
(R-HSA-445455)
SUFU [ciliary tip]
(R-HSA-5610426)
0.773
5
UniProt:Q9NRP7 STK36
0.536
2
UniProt:Q9UNI1 CELA1
0.527
2
UniProt:P46684 ZIC1
0.524
2
UniProt:Q62520 Zic2
1
Zic2 [nucleoplasm]
(R-MMU-9832927)
0.524
2
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