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p-S265-NFATC3 [cytosol]
Stable Identifier
R-HSA-2685614
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Nuclear factor of activated T-cells, cytoplasmic 3, NFAC3_HUMAN, NFATC3
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A (Dectin-1) induces NFAT activation (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Dephosphorylated NFAT [cytosol] (Homo sapiens)
p-S265-NFATC3 [cytosol] (Homo sapiens)
Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Dephosphorylated NFAT [cytosol] (Homo sapiens)
p-S265-NFATC3 [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Dephosphorylated NFAT [cytosol] (Homo sapiens)
p-S265-NFATC3 [cytosol] (Homo sapiens)
Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Dephosphorylated NFAT [cytosol] (Homo sapiens)
p-S265-NFATC3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q12968 NFATC3
Gene Names
NFATC3, NFAT4
Chain
initiator methionine:, chain:2-1075
Reference Genes
BioGPS Gene:4775 NFATC3
COSMIC (genes):NFATC3 NFATC3
CTD Gene:4775 NFATC3
dbSNP Gene:4775 NFATC3
ENSEMBL:ENSG00000072736 NFATC3
HGNC:7777 NFATC3
KEGG:hsa:4775 NFATC3
Monarch:4775 NFATC3
NCBI Gene:4775 NFATC3
OMIM:602698 NFATC3
UCSC:Q12968 NFATC3
Reference Transcript
RefSeq:NM_173165.2 NFATC3
RefSeq:NM_004555.3 NFATC3
RefSeq:NM_173163.2 NFATC3
Other Identifiers
11719501_a_at
11741728_x_at
11745537_a_at
16820367
207416_PM_s_at
207416_s_at
210555_3p_s_at
210555_PM_s_at
210555_s_at
210556_PM_at
210556_at
225137_PM_at
225137_at
225139_PM_at
225139_at
225141_PM_at
225141_at
250_at
3666032
3666034
3666035
3666036
3666037
3666038
3666039
3666040
3666041
3666049
3666050
3666051
3666052
3666053
3666055
3666059
3666065
3666066
3666067
3666071
3666072
3666073
3666074
3666078
3666079
3666080
3666081
3666082
3666083
3666084
3666085
3666086
3666087
3666098
3666100
3666101
3666102
3666103
3666108
3666109
3666110
3666111
3666112
3666114
40822_at
40823_s_at
4775
54806_at
65240_at
7996744
89554_at
A_14_P119085
A_14_P128699
A_23_P77440
A_24_P373312
GE57765
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001227
GO:0001228
GO:0002376
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0005829
GO:0006355
GO:0006357
GO:0006606
GO:0006886
GO:0006913
GO:0006954
GO:0010613
GO:0030154
GO:0033173
GO:0043065
GO:0043226
GO:0045059
GO:0045429
GO:0045893
GO:0045944
GO:0140110
GO:1902894
GO:1904157
GO:1905064
GO:1905653
GO:1990837
HMNXSV003053618
Hs.282093.1.A1_3p_at
Hs.282093.1.A2_3p_at
Hs.282093.1.A3_3p_at
ILMN_1677633
ILMN_1685810
ILMN_1755983
ILMN_1800976
ILMN_2360028
L41067_at
PH_hs_0010332
TC16001610.hg
TC16002056.hg
U85430_at
g1835590_3p_at
g1835590_3p_x_at
g4758803_3p_a_at
p33458
Participates
as a member of
Dephosphorylated NFAT [cytosol] (Homo sapiens)
Other forms of this molecule
p-13S-NFATC3 [cytosol]
p-S265-NFATC3 [nucleoplasm]
Inferred To
phospho-NFATC3 [cytosol]
(Bos taurus)
phospho-NFATC3 [cytosol]
(Canis familiaris)
phospho-NFATC3 [cytosol]
(Gallus gallus)
phospho-NFATC3 [cytosol]
(Sus scrofa)
phospho-Nfatc3 [cytosol]
(Mus musculus)
phospho-Nfatc3 [cytosol]
(Rattus norvegicus)
phospho-NFAT [cytosol]
(Drosophila melanogaster)
phospho-nfatc3 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 265
Coordinate
265
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_004546.1
,
NP_775188.1
,
NP_775186.1
OpenTargets
ENSG00000072736
ENSEMBL
ENSP00000300659
,
ENST00000346183
,
ENSP00000264008
,
ENST00000329524
,
ENSP00000331324
,
ENST00000349223
HPA
ENSG00000072736-NFATC3
PRO
Q12968
Pharos - Targets
Q12968
GlyGen
Q12968
PDB
2XS0
,
2XRW
HMDB Protein
HMDBP07840
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UMX1 SUFU
3
SUFU [ciliary base]
(R-HSA-5610424)
SUFU [cytosol]
(R-HSA-445455)
SUFU [ciliary tip]
(R-HSA-5610426)
0.564
2
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