Reactome | ZIC1 [nucleoplasm]

ZIC1 [nucleoplasm]

Stable Identifier

R-HSA-9731648

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Zinc finger protein ZIC 1, ZIC1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q15915 ZIC1

Gene Names

ZIC1, ZIC, ZNF201

Chain

chain:1-447

Reference Genes

BioGPS Gene:7545 ZIC1

COSMIC (genes):ZIC1 ZIC1

CTD Gene:7545 ZIC1

dbSNP Gene:7545 ZIC1

ENSEMBL:ENSG00000152977 ZIC1

ENSEMBL_homo_sapiens_GENE:ENSG00000152977.10 ZIC1

HGNC:12872 ZIC1

KEGG Gene (Homo sapiens):7545 ZIC1

Monarch:7545 ZIC1

NCBI Gene:7545 ZIC1

OMIM:600470 ZIC1

UCSC:Q15915 ZIC1

Reference Transcript

RefSeq:NM_003412.3 ZIC1

Other Identifiers

11731331_at

11731332_at

206373_PM_at

206373_at

236896_PM_at

236896_at

2646824

2646825

2646826

2646829

2646833

2646834

2646835

2646836

2646837

2646838

2646839

2646840

36308_at

47852_r_at

7545

8083233

A_23_P367618

A_32_P86067

D76435_at

GE530932

GO:0000977

GO:0000978

GO:0000981

GO:0001228

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0006351

GO:0006355

GO:0006357

GO:0006886

GO:0006913

GO:0007389

GO:0007399

GO:0007417

GO:0007420

GO:0007628

GO:0008589

GO:0010467

GO:0021510

GO:0021766

GO:0021772

GO:0023052

GO:0030154

GO:0030900

GO:0042307

GO:0042472

GO:0043226

GO:0045893

GO:0045944

GO:0046872

GO:0048856

GO:0098727

GO:0140110

GO:1990837

HMNXSV003048509

Hs.7177.0.A1_3p_at

ILMN_1774005

PH_hs_0003068

g4507970_3p_at

Participates

as an output of

Expression of ZIC1 in the neural plate border (Homo sapiens)

This entity regulates

Positively

FOXD3 gene expression (Homo sapiens)

Cross References

RefSeq

NP_003403.2

OpenTargets

ENSG00000152977

GeneCards

Q15915

HPA

ENSG00000152977-ZIC1

Ensembl

ENSG00000152977, ENSP00000282928, ENST00000282928

PRO

Q15915

Pharos - Targets

Q15915

Orphanet

15743

Interactors (102)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NRY6 PLS3			0.556	3
UniProt:Q9BYR7 KRTAP3-2	1	KRTAP3-2 [cytosol] (R-HSA-6809857)	0.556	3
UniProt:Q5TA45 CPSF3L	1	CPSF3L [nucleoplasm] (R-HSA-6807411)	0.556	3
UniProt:Q3SYF9 KRTAP19-7	1	KRTAP19-7 [cytosol] (R-HSA-6810305)	0.556	3
UniProt:Q53HC5 KLH26			0.556	3
UniProt:Q9UBV8 PEF1			0.556	3
UniProt:Q8NI38 IKBD			0.556	3
UniProt:Q03989 ARI5A			0.556	3
UniProt:Q8IUB9 KRTAP19-1	1	KRTAP19-1 [cytosol] (R-HSA-6810285)	0.556	3
UniProt:Q8N6F8 MET27			0.556	3
UniProt:P35250-2 RFC2			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q6ZNG0 ZNF620	1	ZNF620 [nucleoplasm] (R-HSA-2127603)	0.556	3
UniProt:Q9HBE1-4 PATZ1			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q52LG2 KRTAP13-2	1	KRTAP13-2 [cytosol] (R-HSA-6810274)	0.556	3
UniProt:O43186 CRX			0.556	3
IntAct:EBI-22384931 CCSB ORF ID			0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:Q15654 TRIP6			0.556	3
UniProt:Q6NVV7 CDPF1			0.556	3
UniProt:Q8NFV4-4 ABHD11			0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:Q3LI59 KRTAP21-2	1	KRTAP21-2 [cytosol] (R-HSA-6810245)	0.556	3
UniProt:O60806 TBX19			0.556	3
UniProt:Q9Y6H3 ATP23			0.556	3
UniProt:Q86WV8 Q86WV8			0.556	3
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.556	5
UniProt:Q6NVU6 UFSP1			0.556	3
UniProt:Q53HV7-2 SMUG1			0.556	3
UniProt:P59990 KRTAP12-1	1	KRTAP12-1 [cytosol] (R-HSA-6810248)	0.556	3
UniProt:Q99932-2 SPAG8			0.556	5
UniProt:Q3LI66 KRTAP6-2	1	KRTAP6-2 [cytosol] (R-HSA-6810261)	0.556	3
UniProt:Q3LI67 KRTAP6-3	1	KRTAP6-3 [cytosol] (R-HSA-6810281)	0.556	3
UniProt:Q3LI64 KRTAP6-1	1	KRTAP6-1 [cytosol] (R-HSA-6810298)	0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.556	3
IntAct:EBI-22616457 CCSB ORF ID			0.556	5
UniProt:Q3LI72 KRTAP19-5	1	KRTAP19-5 [cytosol] (R-HSA-6810300)	0.556	3
UniProt:Q3LI76 KRTAP15-1	1	KRTAP15-1 [cytosol] (R-HSA-6810304)	0.556	3
UniProt:Q9HDD0 PLAAT1	1	HRASLS [cytosol] (R-HSA-8858537)	0.556	3
UniProt:Q3LHN2 KRTAP19-2	1	KRTAP19-2 [cytosol] (R-HSA-6810262)	0.556	3
UniProt:Q86XJ1 GA2L3			0.556	3
UniProt:Q9H5F2 CFA68			0.556	3
UniProt:Q9NR55 BATF3			0.556	3
UniProt:Q9H7B4 SMYD3	1	SMYD3 [nucleoplasm] (R-HSA-5637688)	0.556	3
UniProt:A0PJW8 DAPL1			0.556	3
UniProt:Q8IUC3 KRA71			0.556	3
UniProt:Q8IUC2 KRTAP8-1	1	KRTAP8-1 [cytosol] (R-HSA-6810288)	0.556	5
UniProt:Q8IUC1 KRTAP11-1	1	KRTAP11-1 [cytosol] (R-HSA-6810294)	0.556	3
UniProt:Q6S9Z5 ZN474			0.556	3
UniProt:Q99732 LITAF			0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:O75593 FOXH1	1	FOXH1 [nucleoplasm] (R-HSA-1225914)	0.556	3
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.556	3
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.556	3
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.556	3
UniProt:Q9UMX1 SUFU	3	SUFU [ciliary base] (R-HSA-5610424) SUFU [cytosol] (R-HSA-445455) SUFU [ciliary tip] (R-HSA-5610426)	0.556	3
UniProt:Q93062-3 RBPMS			0.556	3
UniProt:Q96RK4 BBS4	1	BBS4 [cytosol] (R-HSA-5617635)	0.556	3
UniProt:Q496A3 SPAS1			0.556	3
UniProt:Q8TDS5 OXER1	1	OXER1 [plasma membrane] (R-HSA-416425)	0.556	3
UniProt:Q96N21 AP4AT			0.556	3
UniProt:A1KXE4-2 FAM168B			0.556	3
UniProt:Q04864-2 REL			0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
IntAct:EBI-22320186 CCSB ORF ID			0.556	3
UniProt:Q96AZ1 EFMT3			0.556	3
IntAct:EBI-22461217 CCSB ORF ID			0.556	3
IntAct:EBI-23202138 CCSB ORF ID			0.556	3
UniProt:Q9NXR5-2 ANKRD10			0.556	3
UniProt:Q9BVN2 RUSC1			0.556	3
UniProt:Q9NZC7-5 WWOX			0.556	3
UniProt:O60911 CTSV	4	CTSL2 [lysosomal lumen] (R-HSA-1181232) CTSL2 [early endosome lumen] (R-HSA-4127471) CTSL2 [extracellular region] (R-HSA-2228669) CTSL2 [endolysosome lumen] (R-HSA-4127477)	0.527	2
UniProt:Q6ZVX7 FBX50			0.527	2
UniProt:P09668 CTSH	8	CTSH(116-335) [lysosomal lumen] (R-HSA-1181224) CTSH(293-335) [multivesicular body lumen] (R-HSA-5685888) CTSH(116-292) [multivesicular body lumen] (R-HSA-5685904) CTSH(98-105) [multivesicular body lumen] (R-HSA-5685877) CTSH(116-335) [secretory granule lumen] (R-HSA-6801307) CTSH(116-335) [ficolin-1-rich granule lumen] (R-HSA-6801295) CTSH(116-335) [extracellular region] (R-HSA-6801616) CTSH(116-335) [tertiary granule lumen] (R-HSA-6801278)	0.527	2
UniProt:Q9BYJ1 ALOXE3	1	ALOXE3 [cytosol] (R-HSA-8942204)	0.527	2
UniProt:O75342 ALOX12B	1	ALOX12B [cytosol] (R-HSA-2142832)	0.527	2
UniProt:P01040 CSTA	2	CSTA [cornified envelope] (R-HSA-8934840) CSTA [cytosol] (R-HSA-6814194)	0.527	2
UniProt:Q6P4A8 PLBD1	1	PLBD1 [cytosol] (R-HSA-1524034)	0.527	2
UniProt:Q96FQ6 S10AG			0.527	2
UniProt:Q96L46 CAPNS2	2	CAPNS2 [plasma membrane] (R-HSA-8863453) CAPNS2 [cytosol] (R-HSA-8848629)	0.527	2
UniProt:P05090 APOD	1	APOD [extracellular region] (R-HSA-5216199)	0.527	2
UniProt:P25815 S100P	2	S100P [extracellular region] (R-HSA-6804809) S100P [secretory granule lumen] (R-HSA-6804782)	0.527	2
UniProt:P17900 GM2A	3	GM2A(32-193) [extracellular region] (R-HSA-6806181) GM2A(32-193) [azurophil granule lumen] (R-HSA-6799160) GM2A(32-193) [lysosomal lumen] (R-HSA-1605614)	0.527	2
UniProt:P48594 SPB4			0.527	2
UniProt:Q5T749 KPRP	1	KPRP [cytosol] (R-HSA-9839614)	0.527	2
UniProt:Q9H1E1 RNASE7	1	RNASE7 [extracellular region] (R-HSA-6803118)	0.527	2
UniProt:P25311 AZGP1	1	AZGP1 [extracellular region] (R-HSA-5215961)	0.527	2
UniProt:Q8NEX9 SDR9C7	1	SDR9C7 [endoplasmic reticulum membrane] (R-HSA-4084690)	0.527	2
UniProt:P29508 SERPINB3	2	SERPINB3 [extracellular region] (R-HSA-6806189) SERPINB3 [azurophil granule lumen] (R-HSA-6799340)	0.527	2
UniProt:P07476 IVL	2	IVL [cornified envelope] (R-HSA-8847720) IVL [cytosol] (R-HSA-6810837)	0.527	2
UniProt:Q9UI42 CBPA4			0.527	2
UniProt:P31944 CASP14	2	CASP14(6-146) [cytosol] (R-HSA-8847667) CASP14(153-242) [cytosol] (R-HSA-8847687)	0.527	2
UniProt:P31151 S100A7	2	S100A7 [azurophil granule lumen] (R-HSA-6799207) S100A7 [extracellular region] (R-HSA-5432925)	0.527	2
UniProt:P30740 SERPINB1	2	SERPINB1 [extracellular region] (R-HSA-6804818) SERPINB1 [secretory granule lumen] (R-HSA-6804786)	0.527	2
UniProt:P01011 SERPINA3	4	SERPINA3 [platelet alpha granule lumen] (R-HSA-8848913) SERPINA3 [secretory granule lumen] (R-HSA-6801018) SERPINA3 [extracellular region] (R-HSA-6806173) SERPINA3 [azurophil granule lumen] (R-HSA-6798754)	0.527	2
UniProt:Q96QA5 GSDMA			0.527	2
UniProt:P06702 S100A9	3	S100A9 [secretory granule lumen] (R-HSA-6804774) S100A9 [cytosol] (R-HSA-9626869) S100A9 [extracellular region] (R-HSA-5432857)	0.527	2
UniProt:P42357 HAL	1	HAL [cytosol] (R-HSA-70897)	0.527	2
UniProt:P22735 TGM1	3	TGM1 [cytosol] (R-HSA-6813756) TGM1 [cornified envelope] (R-HSA-8847706) TGM1 [plasma membrane] (R-HSA-6813757)	0.527	2

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