Reactome | HARS2 [mitochondrial matrix]

HARS2 [mitochondrial matrix]

Stable Identifier

R-HSA-379581

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Histidyl-tRNA synthetase 2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P49590 HARS2

Gene Names

HARS2, HARSL, HARSR, HO3

Chain

transit peptide:1-33, chain:34-506

Reference Genes

BioGPS Gene:23438 HARS2

COSMIC (genes):HARS2 HARS2

CTD Gene:23438 HARS2

dbSNP Gene:23438 HARS2

ENSEMBL:ENSG00000112855 HARS2

HGNC:4817 HARS2

KEGG:hsa:23438 HARS2

Monarch:23438 HARS2

NCBI Entrez Gene:23438 HARS2

OMIM:600783 HARS2

UCSC:P49590 HARS2

Reference Transcript

Other Identifiers

11717486_a_at

11751295_a_at

16990166

209252_PM_at

209252_at

23438

2832053

2832054

2832055

2832056

2832057

2832058

2832059

2832060

2832061

2832062

2832063

2832064

2832065

2832066

2832067

2832068

2832069

2832070

2832071

2832072

2832073

2832074

2832075

2832076

2832082

2832083

2832084

2832085

37240_at

8108603

A_14_P105484

A_14_P121707

A_23_P41588

GE58987

GO:0000166

GO:0003723

GO:0003824

GO:0004812

GO:0004821

GO:0005515

GO:0005524

GO:0005737

GO:0005739

GO:0005759

GO:0006399

GO:0006412

GO:0006418

GO:0006427

GO:0006520

GO:0016874

GO:0032543

GO:0140098

HMNXSV003004114

ILMN_1715113

PH_hs_0025247

TC05000732.hg

U18937_at

g899108_3p_at

Cross References

RefSeq

NP_036340.1, NP_001265660.1, NP_001265661.1

OpenTargets

ENSG00000112855

ENSEMBL

ENST00000508522, ENST00000230771, ENST00000645749, ENSP00000230771, ENSP00000423616, ENSP00000494296, ENSG00000112855

HPA

ENSG00000112855-HARS2

GeneCards

HARS2

PRO

P49590

Pharos - Targets

P49590

Orphanet

HARS2

HMDB Protein

HMDBP00642

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10809 HSPD1	6	HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.615	5
UniProt:Q6RW13 AGTRAP	2	AGTRAP(1-159)-BRAF(288-545) fusion [cytosol] (R-HSA-6802262) AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol] (R-HSA-6802511)	0.556	3
UniProt:P12081 HARS1	1	HARS [cytosol] (R-HSA-379554)	0.527	2
UniProt:Q07954 LRP1	2	LRP1 [endocytic vesicle membrane] (R-HSA-2230981) LRP1 [plasma membrane] (R-HSA-1454844)	0.527	2
UniProt:Q9UQV4 LAMP3			0.527	3
UniProt:P21912 SDHB	2	SDHB [mitochondrial matrix] (R-HSA-9854983) SDHB [mitochondrial inner membrane] (R-HSA-70985)	0.527	2
UniProt:Q9Y478 PRKAB1	3	PRKAB1 [cytosol] (R-HSA-380968) PRKAB1 [nucleoplasm] (R-HSA-2151199) PRKAB1 [endoplasmic reticulum lumen] (R-HSA-9931300)	0.527	2
UniProt:Q8TBP5 F174A			0.527	3
UniProt:P52815 MRPL12	2	MRPL12 [mitochondrial inner membrane] (R-HSA-5368256) MRPL12 [mitochondrial matrix] (R-HSA-9839674)	0.527	3
UniProt:Q96KS9 F167A			0.527	2
UniProt:P11912 CD79A	2	p-Y188,Y199-CD79A [plasma membrane] (R-HSA-983539) CD79A [plasma membrane] (R-HSA-197154)	0.527	2
UniProt:P58557 YBEY			0.527	2
UniProt:Q9UK85 DKKL1			0.527	2
UniProt:Q7Z2W9 MRPL21	1	MRPL21 [mitochondrial inner membrane] (R-HSA-5368231)	0.527	3
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.527	2
UniProt:P04591-PRO_0000038593 GAG			0.462	3

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