Reactome | ICT1 [mitochondrial matrix]

ICT1 [mitochondrial matrix]

Stable Identifier

R-HSA-5368175

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Peptidyl-tRNA hydrolase ICT1, mitochondrial ecNumber3.1.1.29/ecNumber, ICT1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q14197 MRPL58

Gene Names

MRPL58, DS1, ICT1

Chain

transit peptide:1-29, chain:30-206

Reference Genes

BioGPS Gene:3396 MRPL58

COSMIC (genes):MRPL58 MRPL58

CTD Gene:3396 MRPL58

dbSNP Gene:3396 MRPL58

ENSEMBL:ENSG00000167862 MRPL58

HGNC:5359 MRPL58

KEGG:hsa:3396 MRPL58

Monarch:3396 MRPL58

NCBI Gene:3396 MRPL58

OMIM:603000 MRPL58

UCSC:Q14197 MRPL58

Reference Transcript

Other Identifiers

11728294_at

16837689

204868_PM_at

204868_at

3396

3734577

3734583

3734585

3734586

3734587

3734588

3734589

3734591

3734592

40758_at

8009727

A_14_P126029

A_23_P141194

GE60075

GO:0003747

GO:0003824

GO:0004045

GO:0005654

GO:0005739

GO:0005743

GO:0005759

GO:0005762

GO:0005840

GO:0005886

GO:0006412

GO:0006415

GO:0016150

GO:0016787

GO:0032543

GO:0070126

GO:0072344

GO:0140098

GO:1990904

HMNXSV003057306

ILMN_2182198

PH_hs_0024717

TC17000839.hg

X81788_at

g4557656_3p_at

Participates

as a component of

as an input of

55S mitochondrial ribosome:non-stop mRNA binds ICT1 (MRPL58) (Homo sapiens)

as a member of

MTRF1L, ICT1 [mitochondrial matrix] (Homo sapiens)

Other forms of this molecule

ICT1 [mitochondrial inner membrane]

Inferred To

MRPL58 [mitochondrial matrix] (Bos taurus)

MRPL58 [mitochondrial matrix] (Canis familiaris)

MRPL58 [mitochondrial matrix] (Gallus gallus)

MRPL58 [mitochondrial matrix] (Sus scrofa)

FBgn 32261 [mitochondrial matrix] (Drosophila melanogaster)

mug82 [mitochondrial matrix] (Schizosaccharomyces pombe)

mrpl-58 [mitochondrial matrix] (Caenorhabditis elegans)

ICT1 [mitochondrial matrix] (Dictyostelium discoideum)

ICT1 [mitochondrial matrix] (Plasmodium falciparum)

ICT1 [mitochondrial matrix] (Saccharomyces cerevisiae)

mrpl58 [mitochondrial matrix] (Danio rerio)

mrpl58 [mitochondrial matrix] (Xenopus tropicalis)

Homologues of ICT1 [mitochondrial matrix] (Plasmodium falciparum)

Mrpl58 [mitochondrial matrix] (Mus musculus)

Mrpl58 [mitochondrial matrix] (Rattus norvegicus)

Cross References

RefSeq

NP_001290194.1, NP_001536.1

OpenTargets

ENSG00000167862

ENSEMBL

ENST00000301585, ENSP00000301585, ENSG00000167862

HPA

ENSG00000167862-MRPL58

GeneCards

MRPL58

PRO

Q14197

Pharos - Targets

Q14197

GlyGen

Q14197

HMDB Protein

HMDBP11792

PDB

8OIT, 7QH7, 6NU3, 7OIA, 7OIC, 7OI7, 7ODT, 7A5K, 7O9M, 8XT1, 7PO4, 7A5I, 6ZSC, 7OI8, 7L08, 3J9M, 5OOL, 7A5J, 7QI4, 6ZM5, 6ZSA, 6I9R, 6VMI, 7PD3, 8XT0, 7OF0, 7NQL, 7L20, 8QSJ, 8PK0, 8RRI, 7OF2, 7OF4, 3J7Y, 7O9K, 6NU2, 7QH6, 7OI6, 7ODS, 7OI9, 7ODR, 8K2A, 7A5H, 7OIE, 6ZS9, 8XT3, 5OOM, 7A5G, 7OIB, 8OIR, 7OID, 6ZSD, 6ZSE, 7A5F, 7QI5, 7QI6, 8ANY, 6ZM6, 8QU5, 6VLZ, 6ZSG, 6ZSB, 8XT2, 7OF6, 8K2B, 7OG4, 7OF5, 7OF3, 7OF7

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52815 MRPL12	2	MRPL12 [mitochondrial inner membrane] (R-HSA-5368256) MRPL12 [mitochondrial matrix] (R-HSA-9839674)	0.758	6
UniProt:Q9NP92 MRPS30	1	MRPS30 [mitochondrial inner membrane] (R-HSA-5368258)	0.725	6
UniProt:Q8IXM3 MRPL41	1	MRPL41 [mitochondrial inner membrane] (R-HSA-5368230)	0.725	4
UniProt:Q7Z7H8 MRPL10	1	MRPL10 [mitochondrial inner membrane] (R-HSA-5368182)	0.725	5
UniProt:Q8TAE8 GADD45GIP1	1	GADD45GIP1 [mitochondrial matrix] (R-HSA-5368253)	0.648	3
UniProt:Q4U2R6 MRPL51	1	MRPL51 [mitochondrial inner membrane] (R-HSA-5368168)	0.643	3
UniProt:Q9P0M9 MRPL27	1	MRPL27 [mitochondrial inner membrane] (R-HSA-5368189)	0.643	5
UniProt:Q5T653 MRPL2	1	MRPL2 [mitochondrial inner membrane] (R-HSA-5368170)	0.643	4
UniProt:Q9H0U6 MRPL18	1	MRPL18 [mitochondrial inner membrane] (R-HSA-5368207)	0.643	4
UniProt:Q9BYD1 MRPL13	1	MRPL13 [mitochondrial inner membrane] (R-HSA-5368244)	0.643	4
UniProt:Q8N5N7 MRPL50	1	MRPL50 [mitochondrial inner membrane] (R-HSA-5368181)	0.643	4
UniProt:Q9Y6G3 MRPL42	1	MRPL42 [mitochondrial inner membrane] (R-HSA-5368237)	0.643	4
UniProt:Q13084 MRPL28	1	MRPL28 [mitochondrial inner membrane] (R-HSA-5368246)	0.643	4
UniProt:Q00059 TFAM	3	TFAM [mitochondrial matrix] (R-HSA-163312) TFAM(1-246) [cytosol] (R-HSA-1592203) p-S55,S56,S61,S160-TFAM [mitochondrial matrix] (R-HSA-9838277)	0.527	2
UniProt:P62241 RPS8	2	RPS8 [cytosol] (R-HSA-72385) RPS8 [nucleoplasm] (R-HSA-6791203)	0.527	3
UniProt:Q9BZE1 MRPL37	1	MRPL37 [mitochondrial inner membrane] (R-HSA-5368240)	0.527	2
UniProt:Q9Y2T7 YBOX2			0.527	2
UniProt:Q9NVI7 ATD3A			0.527	2
UniProt:Q9HD33 MRPL47	1	MRPL47 [mitochondrial inner membrane] (R-HSA-5368180)	0.527	3
UniProt:Q04837 SSBP1	1	SSBP1 [mitochondrial matrix] (R-HSA-1592217)	0.527	2
UniProt:Q75WM6 H1FNT			0.527	4
UniProt:Q9NYK5-2 MRPL39			0.527	2
UniProt:Q86TS9 MRPL52	1	MRPL52 [mitochondrial inner membrane] (R-HSA-5368187)	0.527	3
UniProt:Q96EH3 MALSU1	1	MALSU1 [mitochondrial matrix] (R-HSA-9937395)	0.527	3
UniProt:Q9BYD3 MRPL4	1	MRPL4 [mitochondrial inner membrane] (R-HSA-5368212)	0.527	3
UniProt:P51398 DAP3	1	DAP3 [mitochondrial inner membrane] (R-HSA-5368174)	0.462	3
UniProt:P09001 MRPL3	1	MRPL3 [mitochondrial inner membrane] (R-HSA-5368242)	0.462	3

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