Reactome | MTIF2 [mitochondrial matrix]

MTIF2 [mitochondrial matrix]

Stable Identifier

R-HSA-5368271

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Translation initiation factor IF-2, mitochondrial, IF2M_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P46199 MTIF2

Gene Names

MTIF2

Chain

transit peptide:1-29, chain:30-727

Reference Genes

BioGPS Gene:4528 MTIF2

COSMIC (genes):MTIF2 MTIF2

CTD Gene:4528 MTIF2

dbSNP Gene:4528 MTIF2

ENSEMBL:ENSG00000085760 MTIF2

ENSEMBL_homo_sapiens_GENE:ENSG00000085760.15 MTIF2

HGNC:7441 MTIF2

KEGG Gene (Homo sapiens):4528 MTIF2

Monarch:4528 MTIF2

NCBI Gene:4528 MTIF2

OMIM:603766 MTIF2

UCSC:P46199 MTIF2

Reference Transcript

Other Identifiers

11718821_a_at

16897693

203095_PM_at

203095_at

2553732

2553733

2553734

2553736

2553737

2553738

2553740

2553741

2553743

2553744

2553745

2553746

2553747

2553748

2553749

2553751

2553753

2553754

2553757

2553758

2553759

31836_at

4528

8052250

GE57731

GO:0000166

GO:0003723

GO:0003743

GO:0003824

GO:0003924

GO:0005525

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0006412

GO:0006413

GO:0006446

GO:0008135

GO:0016787

GO:0032790

GO:0043024

GO:0043226

GO:0045182

GO:0070124

GO:0140053

HMNXSV003027861

ILMN_1765520

L34600_at

PH_hs_0035608

TC02001859.hg

g4505276_3p_at

Participates

as an output of

39S subunit binds 28S subunit:mRNA:fMet-tRNA (Homo sapiens)

as a component of

MTIF2:GTP [mitochondrial matrix] (Homo sapiens)

Cross References

RefSeq

XP_005264392.1, XP_011531173.1, NP_001307934.1, NP_001307931.1, NP_002444.2, NP_001307933.1, XP_016859652.1, NP_001307930.1, XP_016859651.1, NP_001005369.1, NP_001307932.1

OpenTargets

ENSG00000085760

GeneCards

P46199

HPA

ENSG00000085760-MTIF2

Ensembl

ENST00000403721, ENST00000263629, ENSG00000085760, ENSP00000378099, ENST00000394600, ENSP00000384481, ENSP00000263629

PRO

P46199

Pharos - Targets

P46199

HMDB Protein

HMDBP08453

PDB

6GAW, 7PO2, 6GAZ, 6GB2, 6RW5

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BVS5 TRMT61B	1	TRMT61B [mitochondrial matrix] (R-HSA-6787512)	0.615	4
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.527	3
UniProt:Q6IN84 MRM1	1	MRM1 [mitochondrial matrix] (R-HSA-6793088)	0.527	3
UniProt:Q7Z2W9 MRPL21	1	MRPL21 [mitochondrial inner membrane] (R-HSA-5368231)	0.527	3
UniProt:O00330 PDHX	1	PDHX [mitochondrial matrix] (R-HSA-70059)	0.527	2
UniProt:P58557 YBEY			0.527	2
UniProt:O95299 NDUFA10	1	NDUFA10 [mitochondrial inner membrane] (R-HSA-163937)	0.527	2
UniProt:O95861 BPNT1	1	BPNT1 [cytosol] (R-HSA-176573)	0.527	2
UniProt:P30049 ATP5F1D	1	ATP5F1D [mitochondrial matrix] (R-HSA-164574)	0.527	2
UniProt:O95661 DIRA3			0.527	2
UniProt:P52815 MRPL12	2	MRPL12 [mitochondrial matrix] (R-HSA-9839674) MRPL12 [mitochondrial inner membrane] (R-HSA-5368256)	0.527	3
UniProt:P49411 TUFM	2	TUFM [mitochondrial matrix] (R-HSA-5389846) TUFM [mitochondrial outer membrane] (R-HSA-9754777)	0.527	2
UniProt:Q96DR7 ARHGEF26	1	ARHGEF26 [cytosol] (R-HSA-8873912)	0.527	2
UniProt:Q96BQ3 TRI43			0.527	2
UniProt:Q9H4K7 MTG2			0.527	3
UniProt:P43897 TSFM	1	TSFM [mitochondrial matrix] (R-HSA-5389837)	0.527	3
UniProt:Q9HC36 MRM3	1	RNMTL1 [mitochondrial matrix] (R-HSA-6793067)	0.527	2
UniProt:Q92506 HSD17B8	1	HSD17B8 [mitochondrial matrix] (R-HSA-8862105)	0.527	2
UniProt:P53370 NUDT6			0.527	2
UniProt:Q9BYZ2 LDHAL6B	1	LDHAL6B [mitochondrial matrix] (R-HSA-6807613)	0.527	2
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.527	2

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