Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
p-T779-ITGB3 [plasma membrane]
Stable Identifier
R-HSA-432107
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-(T779) Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIa, CD61 antigen
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Homo sapiens)
Integrin alpha IIb p(T779)-beta 3 [plasma membrane] (Homo sapiens)
p-T779-ITGB3 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Homo sapiens)
Integrin alpha IIb p(T779)-beta 3 [plasma membrane] (Homo sapiens)
p-T779-ITGB3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05106 ITGB3
Gene Names
ITGB3, GP3A
Chain
signal peptide:1-26, chain:27-788
Reference Genes
BioGPS Gene:3690 ITGB3
COSMIC (genes):ITGB3 ITGB3
CTD Gene:3690 ITGB3
dbSNP Gene:3690 ITGB3
ENSEMBL:ENSG00000259207 ITGB3
HGNC:6156 ITGB3
KEGG Gene (Homo sapiens):3690 ITGB3
Monarch:3690 ITGB3
NCBI Gene:3690 ITGB3
OMIM:173470 ITGB3
UCSC:P05106 ITGB3
Reference Transcript
RefSeq:NM_000212.2 ITGB3
Other Identifiers
0006420722
0103170402
11735062_at
11735063_a_at
11735064_at
11735065_a_at
11735066_at
11755065_a_at
16835158
204625_PM_s_at
204625_s_at
204626_PM_s_at
204626_s_at
204627_PM_s_at
204627_s_at
204628_PM_s_at
204628_s_at
242094_PM_at
242094_at
3690
3724547
3724552
3724554
3724555
3724556
3724557
3724558
3724559
3724560
3724562
3724563
3724564
3724566
3724569
3724570
3724571
3724572
3724573
3724575
3724576
3724577
3724582
3724583
3724584
3724585
37952_at
73263_at
8007931
A_14_P115980
A_14_P131651
A_23_P38519
A_24_P318656
A_24_P889473
GE57949
GO:0000902
GO:0001618
GO:0001934
GO:0001938
GO:0001968
GO:0002020
GO:0003674
GO:0003756
GO:0005161
GO:0005178
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005886
GO:0005887
GO:0005911
GO:0005925
GO:0006464
GO:0006810
GO:0006950
GO:0007155
GO:0007160
GO:0007165
GO:0007229
GO:0007596
GO:0008150
GO:0008283
GO:0008305
GO:0009790
GO:0009986
GO:0010595
GO:0010745
GO:0010888
GO:0014909
GO:0015026
GO:0016020
GO:0016021
GO:0016192
GO:0016477
GO:0016853
GO:0017134
GO:0019899
GO:0019960
GO:0030054
GO:0030154
GO:0030168
GO:0030949
GO:0031092
GO:0031258
GO:0031410
GO:0031527
GO:0031528
GO:0031589
GO:0031994
GO:0032147
GO:0032369
GO:0032587
GO:0032880
GO:0032991
GO:0033627
GO:0034113
GO:0034446
GO:0034683
GO:0035295
GO:0035866
GO:0035867
GO:0035868
GO:0038027
GO:0038132
GO:0040011
GO:0042060
GO:0042470
GO:0042592
GO:0042802
GO:0042995
GO:0043184
GO:0043226
GO:0043235
GO:0043277
GO:0044403
GO:0045124
GO:0045202
GO:0045211
GO:0046718
GO:0048333
GO:0048646
GO:0048856
GO:0048870
GO:0050731
GO:0050748
GO:0050839
GO:0050840
GO:0050919
GO:0051611
GO:0060055
GO:0070062
GO:0070527
GO:0071062
GO:0098978
GO:0099149
GO:1905598
HMNXSV003022425
Hs.225198.0.A1_3p_at
Hs.87149.0.A1_3p_a_at
Hs.87149.2.A1_3p_a_at
ILMN_1661614
ILMN_1733324
M35999_at
PH_hs_0004893
PH_hs_0012597
TC17002878.hg
g183452_3p_a_at
g183532_3p_a_at
g4557676_3p_a_at
Participates
as a component of
Integrin alpha IIb p(T779)-beta 3 [plasma membrane] (Homo sapiens)
Other forms of this molecule
ITGB3(27-?) [platelet alpha granule membrane]
ITGB3 [plasma membrane]
Inferred To
phospho-itgb3b [plasma membrane]
(Danio rerio)
phospho-mys [plasma membrane]
(Drosophila melanogaster)
phospho-Itgbn [plasma membrane]
(Drosophila melanogaster)
Homologues of p-T779-ITGB3 [plasma membrane]
(Drosophila melanogaster)
phospho-ITGB3 [plasma membrane]
(Bos taurus)
phospho-ITGB3 [plasma membrane]
(Canis familiaris)
phospho-ITGB3 [plasma membrane]
(Gallus gallus)
phospho-Itgb3 [plasma membrane]
(Mus musculus)
phospho-Itgb3 [plasma membrane]
(Rattus norvegicus)
phospho-pat-3 [plasma membrane]
(Caenorhabditis elegans)
Modified Residues
Name
O-phospho-L-threonine at 779
Coordinate
779
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_000203.2
Guide to Pharmacology - Targets
2457
OpenTargets
ENSG00000259207
HPA
ENSG00000259207-ITGB3
GeneCards
P05106
Ensembl
ENSG00000259207
,
ENST00000559488
,
ENSP00000452786
PRO
P05106
Pharos - Targets
P05106
Orphanet
16274
PDB
3NID
,
3FCS
,
3T3M
,
2VDQ
,
6MK0
,
2VDR
,
4O02
,
3ZE1
,
3ZE0
,
3ZDX
,
2VDP
,
6NAJ
,
2VDN
,
2KNC
,
1KUZ
,
4MMZ
,
1TYE
,
2RN0
,
2N9Y
,
4MMY
,
6MSL
,
6BXJ
,
6AVU
,
1MIZ
,
4G1M
,
2VDL
,
2KV9
,
3NIG
,
4MMX
,
4Z7Q
,
6BXF
,
3NIF
,
2Q6W
,
1MK9
,
6AVR
,
7KN0
,
1L5G
,
6AVQ
,
4Z7N
,
3T3P
,
4G1E
,
6CKB
,
3FCU
,
3ZDZ
,
1MK7
,
2L1C
,
1M8O
,
3ZDY
,
2VDO
,
4CAK
,
6V4P
,
1M1X
,
5HDB
,
6MSU
,
1S4X
,
2VDM
,
1KUP
,
2MTP
,
2L91
,
2K9J
,
1JV2
,
2RMZ
,
1U8C
,
2VC2
,
2VDK
,
2LJF
,
2LJE
,
3IJE
,
3ZE2
,
4Z7O
,
2LJD
,
6BXB
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26039
2
Tln1 [extracellular region]
(R-MMU-350693)
Tln1 [cytosol]
(R-MMU-350713)
0.842
8
UniProt:P08514 ITGA2B
2
ITGA2B(32-?) [platelet alpha granule membrane]
(R-HSA-114511)
ITGA2B(32-1039) [plasma membrane]
(R-HSA-57578)
0.815
12
UniProt:P02751 FN1
10
FN1(32-2386) [platelet alpha granule lumen]
(R-HSA-114620)
FN1(32-271) [extracellular region]
(R-HSA-3787935)
FN1(272-2386) [extracellular region]
(R-HSA-3788024)
FN1(32-?) [extracellular region]
(R-HSA-2533850)
FN1(?-2386) [extracellular region]
(R-HSA-2533841)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713462)
FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713459)
p-FN1 [endoplasmic reticulum lumen]
(R-HSA-8956937)
FN1 [endoplasmic reticulum lumen]
(R-HSA-8956708)
FN1(32-2386) [extracellular region]
(R-HSA-54851)
0.75
5
UniProt:Q9Y490 TLN1
2
TLN1 [extracellular region]
(R-HSA-350693)
TLN1 [cytosol]
(R-HSA-350713)
0.74
6
UniProt:P78423 CX3CL1
1
CX3CL1 [extracellular region]
(R-HSA-373368)
0.718
7
UniProt:P21333 FLNA
3
FLNA [extracellular region]
(R-HSA-350712)
p-S2152-FLNA [cytosol]
(R-HSA-5669246)
FLNA [cytosol]
(R-HSA-210019)
0.611
3
UniProt:P97465
2
phospho-Dok1 [cytosol]
(R-MMU-8848784)
Dok1 [cytosol]
(R-MMU-74763)
0.602
3
UniProt:Q9QZS3 Numb
2
Numb [plasma membrane]
(R-MMU-2077469)
Numb [plasma membrane]
(R-MMU-443595)
0.544
2
UniProt:P05094
3
ACTN1 [extracellular region]
(R-GGA-349722)
ACTN1 [platelet alpha granule lumen]
(R-GGA-349724)
ACTN1 [cytosol]
(R-GGA-354096)
0.524
2
UniProt:P18031 PTPN1
1
PTPN1 [cytosol]
(R-HSA-210625)
0.499
4
UniProt:P23471 PTPRZ1
2
C4S-PTPRZ1 [plasma membrane]
(R-HSA-9699799)
PTPRZ1 [plasma membrane]
(R-HSA-374561)
0.463
2
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text