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CX3CL1 [extracellular region]
Stable Identifier
R-HSA-373368
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Fractalkine, X3CL1_HUMAN, Soluble CX3CL1
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CX3CR1:CX3CL1 [plasma membrane] (Homo sapiens)
CX3CL1 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CX3CR1:CX3CL1 [plasma membrane] (Homo sapiens)
CX3CL1 [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CX3CR1:CX3CL1 [plasma membrane] (Homo sapiens)
CX3CL1 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CX3CR1:CX3CL1 [plasma membrane] (Homo sapiens)
CX3CL1 [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CX3CR1:CX3CL1 [plasma membrane] (Homo sapiens)
CX3CL1 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CX3CR1:CX3CL1 [plasma membrane] (Homo sapiens)
CX3CL1 [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
CX3CR1 binds CX3CL1 (Homo sapiens)
CX3CL1 [extracellular region] (Homo sapiens)
CX3CR1:CX3CL1 [plasma membrane] (Homo sapiens)
CX3CL1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78423 CX3CL1
Gene Names
CX3CL1, FKN, NTT, SCYD1, A-152E5.2
Chain
signal peptide:1-24, chain:25-397, chain:25-339
Reference Genes
BioGPS Gene:6376 CX3CL1
COSMIC (genes):CX3CL1 CX3CL1
CTD Gene:6376 CX3CL1
dbSNP Gene:6376 CX3CL1
ENSEMBL:ENSG00000006210 CX3CL1
HGNC:10647 CX3CL1
KEGG:hsa:6376 CX3CL1
Monarch:6376 CX3CL1
NCBI Gene:6376 CX3CL1
OMIM:601880 CX3CL1
UCSC:P78423 CX3CL1
Reference Transcript
RefSeq:NM_002996.4 CX3CL1
Other Identifiers
11734551_a_at
11734552_a_at
16819484
203687_PM_at
203687_at
3662697
3662698
3662702
3662703
3662704
3662705
3662706
3662707
3662708
3662709
6376
7996027
823_PM_at
823_at
A_23_P37727
A_24_P381901
A_24_P390495
GE59499
GO:0001774
GO:0001954
GO:0002052
GO:0002376
GO:0002523
GO:0002931
GO:0005102
GO:0005125
GO:0005178
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006355
GO:0006935
GO:0006952
GO:0006954
GO:0006955
GO:0007155
GO:0007165
GO:0007186
GO:0007267
GO:0008009
GO:0008284
GO:0009986
GO:0010812
GO:0010976
GO:0016020
GO:0016322
GO:0019221
GO:0023052
GO:0030335
GO:0030336
GO:0030593
GO:0030595
GO:0031664
GO:0031737
GO:0032233
GO:0032690
GO:0032691
GO:0032715
GO:0032720
GO:0032914
GO:0033622
GO:0034330
GO:0035425
GO:0042056
GO:0042060
GO:0042995
GO:0043005
GO:0043025
GO:0043066
GO:0043123
GO:0043410
GO:0044297
GO:0045237
GO:0045944
GO:0048018
GO:0048020
GO:0048167
GO:0048245
GO:0048247
GO:0048471
GO:0048661
GO:0048870
GO:0050729
GO:0050767
GO:0050902
GO:0050918
GO:0051041
GO:0051281
GO:0051897
GO:0060055
GO:0060326
GO:0061518
GO:0061844
GO:0065003
GO:0070050
GO:0070098
GO:0070374
GO:0097192
GO:0098542
GO:0098609
GO:0098772
GO:0098883
GO:0110091
GO:1900450
GO:1903721
GO:1903979
GO:1904141
GO:2001223
GO:2001234
GO:2001240
HMNXSV003023330
HMNXSV003030962
ILMN_1654072
PH_hs_0035471
TC16000488.hg
U84487_at
g4506856_3p_s_at
Participates
as an input of
CX3CR1 binds CX3CL1 (Homo sapiens)
as a component of
CX3CR1:CX3CL1 [plasma membrane] (Homo sapiens)
Inferred To
CCL26 [extracellular region]
(Gallus gallus)
CCLi7 [extracellular region]
(Gallus gallus)
CCLi8 [extracellular region]
(Gallus gallus)
CCL4 [extracellular region]
(Gallus gallus)
Cx3cl1 [extracellular region]
(Mus musculus)
Cx3cl1 [extracellular region]
(Rattus norvegicus)
cx3cl1 [extracellular region]
(Canis familiaris)
CX3CL1 [extracellular region]
(Gallus gallus)
CCLi9 [extracellular region]
(Gallus gallus)
Homologues of CX3CL1 [extracellular region]
(Gallus gallus)
Q5IEZ5 [extracellular region]
(Gallus gallus)
A0A3Q1LPV5 [extracellular region]
(Bos taurus)
Cross References
RefSeq
NP_002987.1
ENSEMBL
ENST00000006053
,
ENSP00000006053
OpenTargets
ENSG00000006210
HPA
ENSG00000006210-CX3CL1
PRO
P78423
Pharos - Targets
P78423
GlyGen
P78423
PDB
7RKF
,
7RKN
,
3ONA
,
1F2L
,
7RKM
,
1B2T
,
7XBX
,
4XT1
,
4XT3
,
5WB2
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05106 ITGB3
3
ITGB3 [plasma membrane]
(R-HSA-57600)
ITGB3(27-?) [platelet alpha granule membrane]
(R-HSA-114512)
p-T779-ITGB3 [plasma membrane]
(R-HSA-432107)
0.688
6
UniProt:A0A061IJ01 A0A061IJ01
0.656
5
UniProt:P69332 US28
0.645
4
UniProt:P02679 FGG
5
FGG [extracellular region]
(R-HSA-140585)
FGG [endoplasmic reticulum lumen]
(R-HSA-8956692)
p-FGG [endoplasmic reticulum lumen]
(R-HSA-8956993)
FGG [plasma membrane]
(R-HSA-140918)
FGG [platelet alpha granule lumen]
(R-HSA-140922)
0.524
3
UniProt:P05556 ITGB1
2
ITGB1 [plasma membrane]
(R-HSA-57596)
ITGB1 [endosome membrane]
(R-HSA-9611157)
0.524
2
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