Reactome | Numb [plasma membrane]

Numb [plasma membrane]

Stable Identifier

R-MMU-443595

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

NUMB, Q9QZS3

Locations in the PathwayBrowser

Expand all

Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - L1CAM interactions (Mus musculus)
      - Recycling pathway of L1 (Mus musculus)
        
        Interaction of NUMB with L1 (Mus musculus)
        
        CRMP-2:NUMB:alpha adaptin [plasma membrane] (Mus musculus)
        
        Numb [plasma membrane] (Mus musculus)
        
        L1:NUMB:CRMP-2:alpha-adaptin [clathrin-coated endocytic vesicle] (Mus musculus)
        
        CRMP-2:NUMB:alpha adaptin [plasma membrane] (Mus musculus)
        
        Numb [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9QZS3 Numb

Gene Names

Numb

Chain

chain:1-653

Reference Genes

BioGPS Gene:18222 NUMB

KEGG:mmu:18222 NUMB

Monarch:18222 NUMB

NCBI Gene:18222 NUMB

UCSC:Q9QZS3 NUMB

Reference Transcript

Participates

as a component of

as an input of

NUMB binds ITCH (Mus musculus)

Other forms of this molecule

Numb [plasma membrane]

Inferred From

NUMB [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001129547.1, NP_001398881.1, NP_001398880.1, NP_001258984.1, NP_001398879.1, NP_001398878.1, NP_035079.1, XP_006515640.1, XP_011242314.1, NP_001258985.1

ENSEMBL

ENSMUST00000117217, ENSMUST00000129335, ENSMUSP00000119303, ENSMUSG00000021224, ENSMUSP00000117899, ENSMUSP00000021647, ENSMUST00000154043, ENSMUSP00000113591, ENSMUST00000021647

PRO

Q9QZS3

MGI

107423

PDB

1WJ1, 5YQG

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05106 ITGB3	3	ITGB3 [plasma membrane] (R-HSA-57600) ITGB3(27-?) [platelet alpha granule membrane] (R-HSA-114512) p-T779-ITGB3 [plasma membrane] (R-HSA-432107)	0.544	2
UniProt:P12023	11	APP(672-713) [extracellular region] (R-MMU-879340) APP(672-711) [extracellular region] (R-MMU-976740) APP(18-770) [platelet alpha granule lumen] (R-MMU-139835) APP(18-770) [extracellular region] (R-MMU-49335) APP [endoplasmic reticulum lumen] (R-MMU-8956696) phospho-p-APP [endoplasmic reticulum lumen] (R-MMU-8957012) APP(18-770) [endosome lumen] (R-MMU-5229077) APP [mitochondrial inner membrane] (R-MMU-9839060) APP (535-695) [cytosol] (R-MMU-9839084) APP-C99 [cytosol] (R-MMU-9617603) APP(18-770) [trans-Golgi network membrane] (R-MMU-5229136)	0.471	2

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