Reactome | ITGA2B(32-?) [platelet alpha granule membrane]

ITGA2B(32-?) [platelet alpha granule membrane]

Stable Identifier

R-HSA-114511

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet alpha granule membrane

Synonyms

Integrin alpha-IIb, Platelet membrane glycoprotein IIb, GPalpha IIb, GPIIb, CD41 antigen

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P08514 ITGA2B

Gene Names

ITGA2B, GP2B, ITGAB

Chain

signal peptide:1-31, chain:32-1039, chain:32-887, chain:891-1039, chain:903-1039

Reference Genes

BioGPS Gene:3674 ITGA2B

COSMIC - genes:ITGA2B ITGA2B

CTD Gene:3674 ITGA2B

dbSNP Gene:3674 ITGA2B

ENSEMBL:ENSG00000005961 ITGA2B

HGNC:6138 ITGA2B

KEGG:hsa:3674 ITGA2B

Monarch:3674 ITGA2B

NCBI Gene:3674 ITGA2B

OMIM:607759 ITGA2B

UCSC:P08514 ITGA2B

Reference Transcript

RefSeq:NM_000419.5 ITGA2B

Participates

as a component of

Alpha IIb Beta 3 Integrin [platelet alpha granule membrane] (Homo sapiens)

Other forms of this molecule

ITGA2B(32-1039) [plasma membrane]

Inferred To

ITGA2B [platelet alpha granule membrane] (Canis familiaris)

ITGA2B [platelet alpha granule membrane] (Gallus gallus)

ITGA2B [platelet alpha granule membrane] (Sus scrofa)

pat-2 [platelet alpha granule membrane] (Caenorhabditis elegans)

itga2b [platelet alpha granule membrane] (Danio rerio)

itga2b [platelet alpha granule membrane] (Xenopus tropicalis)

ITGA2B(32-?) [platelet alpha granule membrane] (Bos taurus)

ITGA2B(32-?) [platelet alpha granule membrane] (Mus musculus)

if [platelet alpha granule membrane] (Drosophila melanogaster)

Itga2b [platelet alpha granule membrane] (Rattus norvegicus)

Cross References

Guide to Pharmacology - Targets

2441

OpenTargets

ENSG00000005961

ENSEMBL

ENSG00000005961, ENSP00000262407, ENST00000262407

ZINC - Substances

ITA2B_HUMAN

ZINC target

P08514

PRO

P08514

PDB

9DEQ, 7UKO, 4Z7O, 1S4W, 2N9Y, 9DAO, 1TYE, 2VC2, 2MTP, 8T2V, 3T3P, 8GCE, 7U60, 7TCT, 7UJE, 7TD8, 2KNC, 2K9J, 2VDM, 9DAX, 3FCU, 7L8P, 3ZE2, 3ZDZ, 7THO, 1KUP, 3NIF, 1M8O, 3ZE0, 7UBR, 7SFT, 6V4P, 1DPK, 7UH8, 4CAK, 7UKT, 5HDB, 7TMZ, 2VDO, 9AXL, 4Z7N, 7KN0, 2VDR, 2VDQ, 9DER, 2VDP, 7UE0, 3T3M, 7UJK, 7UDG, 7UDH, 2VDK, 7TPD, 1KUZ, 7U9V, 8GCD, 7U9F, 2VDN, 2K1A, 3ZDX, 7SC4, 2VDL, 3NID, 3FCS, 3ZDY, 8T2U, 4Z7Q, 3ZE1, 7UK9, 7LA4, 3NIG, 7UFH, 7UCY, 1DPQ, 7UKP

HPA

ENSG00000005961-ITGA2B

GeneCards

ITGA2B

Pharos - Targets

P08514

Orphanet

ITGA2B

ZINC - Predictions - Purchasable

ITA2B_HUMAN

HMDB Protein

HMDBP02103

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05106 ITGB3	3	ITGB3 [plasma membrane] (R-HSA-57600) ITGB3(27-?) [platelet alpha granule membrane] (R-HSA-114512) p-T779-ITGB3 [plasma membrane] (R-HSA-432107)	0.815	12
UniProt:P08514 ITGA2B	2	ITGA2B(32-1039) [plasma membrane] (R-HSA-57578) ITGA2B(32-?) [platelet alpha granule membrane] (R-HSA-114511)	0.795	7

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