DCC mediated attractive signaling

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser
The DCC family includes DCC and neogenin in vertebrates. DCC is required for netrin-induced axon attraction. DCC is a transmembrane protein lacking any identifiable catalytic activity. Protein tyrosine kinase 2/FAK and src family kinases bind constitutively to the cytoplasmic domain of DCC and their activation couples to downstream intracellular signaling complex that directs the organization of actin.
Literature References
PubMed ID Title Journal Year
15960985 The Netrin family of guidance factors: emphasis on Netrin-1 signalling

Barallobre, MJ, Pascual, M, Soriano, E, Del Rio, JA

Brain Res Brain Res Rev 2005
17254765 Netrin signaling leading to directed growth cone steering

Round, J, Stein, E

Curr Opin Neurobiol 2007
15557120 Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance

Webber, CA, Bloch-Gallego, E, Tcherkezian, J, McFarlane, S, Meriane, M, Triki, I, Danek, EI, Lamarche-Vane, N

J Cell Biol 2004
11817894 The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1

Shekarabi, M, Kennedy, TE

Mol Cell Neurosci 2002
11239160 Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation

Stein, E, Poo, M, Zou, Y, Tessier-Lavigne, M

Science 2001
15494733 Focal adhesion kinase in netrin-1 signaling

Chen, ZF, Wang, Q, Xie, Y, Ming, GL, Feng, Z, Sun, DM, Mei, L, Zhao, ZQ, Hong, Y, Song, HJ, Ren, XR, Xiong, WC, Shim, S

Nat Neurosci 2004
12149262 The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism

Larose, L, Li, X, Meriane, M, Triki, I, Lamarche-Vane, N, Shekarabi, M, Kennedy, TE

J Biol Chem 2002
9950216 Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas

Hu, G, Eckstrand, BC, Caca, K, Fearon, ER, Look, AT, Meyerhardt, JA, Lengauer, C, Banavali, S

Cell Growth Differ 1999
Orthologous Events
Cross References
BioModels Database
Cite Us!