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Recruitment of ABLIM to the plasma membrane
Stable Identifier
R-HSA-418865
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Netrin-1 signaling (Homo sapiens)
DCC mediated attractive signaling (Homo sapiens)
Recruitment of ABLIM to the plasma membrane (Homo sapiens)
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Unc-115/AbLIM is a key regulator of lamellipodia and filopodia in the growth cone during axon pathfinding and acts downstream of Rac GTPase signaling. It acts as a scaffold to recruit other actin-modulating complexes involved in lamellipodia and filopodia. Unc-115/AbLIM is locally recruited to the plasma membrane by activated Rac1 and subsequently dephosphorylated on serine 617. Dephosphorylated Unc-115/AbLIM then might interact with other molecules at the plasma membrane to induce formation of lamellipodia and filopodia by reorganization of the actin cytoskeleton.
Participants
Input
ABLIM [cytosol]
(Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane]
(Homo sapiens)
Output
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP:ABLIM [plasma membrane]
(Homo sapiens)
Participates
as an event of
DCC mediated attractive signaling (Homo sapiens)
Inferred From
Recruitment of ABLIM to the plasma membrane (Caenorhabditis elegans)
Authored
Garapati, P V (2008-07-16)
Reviewed
Cooper, HM (2010-02-16)
Created
Garapati, P V (2009-04-27)
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