Reactome | Recruitment of Src and Fyn to DCC:FADK1

Recruitment of Src and Fyn to DCC:FADK1

Stable Identifier

R-HSA-418868

Type

Reaction

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Activated (phosphorylated) FADK1 acts as a scaffold and recruits src tyrosine kinases Src and Fyn to DCC. These tyrosine kinases phosphorylate DCC which is critical for Netrin-1 signaling.

Literature References

PubMed ID	Title	Journal	Year
15557120	Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance Webber, CA, Bloch-Gallego, E, Tcherkezian, J, McFarlane, S, Meriane, M, Triki, I, Danek, EI, Lamarche-Vane, N	J Cell Biol	2004
15494734	Activation of FAK and Src are receptor-proximal events required for netrin signaling Vikis, HG, Aurandt, J, Shen, TL, Fearon, ER, Lee, J, Lee, SH, Hong, K, Li, W, Guan, JL, Guan, KL, Rao, Y, Han, M, Liu, G	Nat Neurosci	2004
15494732	Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction Reichardt, LF, Beggs, H, Rao, Y, Park, HT, Tang, H, Jürgensen, C, Gorski, J, Liu, G, Wu, J, Jones, KR	Nat Neurosci	2004