Recruitment of Src and Fyn to DCC:FADK1

Stable Identifier
R-HSA-418868
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Recruitment of Src and Fyn to DCC:FADK1
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Activated (phosphorylated) FADK1 acts as a scaffold and recruits src tyrosine kinases Src and Fyn to DCC. These tyrosine kinases phosphorylate DCC which is critical for Netrin-1 signaling.
Literature References
PubMed ID Title Journal Year
15557120 Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance

Webber, CA, Bloch-Gallego, E, Tcherkezian, J, McFarlane, S, Meriane, M, Triki, I, Danek, EI, Lamarche-Vane, N

J Cell Biol 2004
15494734 Activation of FAK and Src are receptor-proximal events required for netrin signaling

Vikis, HG, Aurandt, J, Shen, TL, Fearon, ER, Lee, J, Lee, SH, Hong, K, Li, W, Guan, JL, Guan, KL, Rao, Y, Han, M, Liu, G

Nat Neurosci 2004
15494732 Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction

Reichardt, LF, Beggs, H, Rao, Y, Park, HT, Tang, H, Jürgensen, C, Gorski, J, Liu, G, Wu, J, Jones, KR

Nat Neurosci 2004
Participants
Input
Output
Participates
as an event of
Orthologous Events
Recruitment of Src and Fyn to DCC:FADK1 (Caenorhabditis elegans)
Authored
Garapati, P V  (2008-07-16)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-04-27)
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