Reactome | Phosphorylation of DCC by Fyn

Phosphorylation of DCC by Fyn

Stable Identifier

R-HSA-374701

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Netrin-1 stimulates phosphorylation of DCC on serine, threonine, and tyrosine residues. The experimental data suggest that tyrosine phosphorylation of DCC is a prerequisite step for DCC phosphorylation on serine and threonine residues. Fyn initiates the phosphorylation of the tyrosine residue 1420 in the DCC cytoplasmic domain. This phosphorylation of DCC in turn facilitates the DCC-Fyn interaction, forming a positive reinforcement cycle.

Literature References

PubMed ID	Title	Journal	Year
15557120	Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance Webber, CA, Bloch-Gallego, E, Tcherkezian, J, McFarlane, S, Meriane, M, Triki, I, Danek, EI, Lamarche-Vane, N	J Cell Biol	2004
18253061	Tyrosine phosphorylation of netrin receptors in netrin-1 signaling Ren, XR, Xiong, WC, Yang, HM, Feng, Z, Mei, L, Hong, Y	Neurosignals	2008