Phosphorylation of DCC by Fyn

Stable Identifier
R-HSA-374701
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Netrin-1 stimulates phosphorylation of DCC on serine, threonine, and tyrosine residues. The experimental data suggest that tyrosine phosphorylation of DCC is a prerequisite step for DCC phosphorylation on serine and threonine residues. Fyn initiates the phosphorylation of the tyrosine residue 1420 in the DCC cytoplasmic domain. This phosphorylation of DCC in turn facilitates the DCC-Fyn interaction, forming a positive reinforcement cycle.

Literature References
PubMed ID Title Journal Year
18253061 Tyrosine phosphorylation of netrin receptors in netrin-1 signaling

Ren, XR, Hong, Y, Feng, Z, Yang, HM, Mei, L, Xiong, WC

Neurosignals 2008
15557120 Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance

Meriane, M, Tcherkezian, J, Webber, CA, Danek, EI, Triki, I, McFarlane, S, Bloch-Gallego, E, Lamarche-Vane, N

J Cell Biol 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of NTN1:DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Created