Phosphorylation of FADK1

Stable Identifier
R-HSA-418872
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Phosphorylation of FADK1
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FADK1 interacts with the C-terminal P3 domain of DCC complexed with Netrin-1, and undergoes tyrosine phosphorylation and activation. Netrin-1-DCC binding thus leads to the autophosphorylation of tyrosine 393 in FADK1.

Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of NTN1:DCC oligomer:PTK2 [plasma membrane]
Physical Entity
NTN1:DCC oligomer:PTK2 [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Inferred From
Phosphorylation of FADK1 (Mus musculus)
Authored
Garapati, P V  (2008-07-16)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-04-27)