DCC interacting NCK-1

Stable Identifier
R-HSA-373716
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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DCC interacting NCK-1
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DCC interacts with the SH3/SH2 adaptor NCK1 in commissural neurons. This interaction is direct and requires the SH3 but not SH2 domains of NCK1. NCK1 can recruit Rac, Cdc42 and their effectors Pak and N-WASP to the activated receptor, thereby providing a direct link between DCC, Rho GTPases and numerous downstream signaling components that regulate the actin cytoskeleton.
Literature References
PubMed ID Title Journal Year
12149262 The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism

Larose, L, Li, X, Meriane, M, Triki, I, Lamarche-Vane, N, Shekarabi, M, Kennedy, TE

J Biol Chem 2002
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Orthologous Events
DCC interacting NCK-1 (Bos taurus)
DCC interacting NCK-1 (Caenorhabditis elegans)
DCC interacting NCK-1 (Canis familiaris)
DCC interacting NCK-1 (Danio rerio)
DCC interacting NCK-1 (Drosophila melanogaster)
DCC interacting NCK-1 (Mus musculus)
DCC interacting NCK-1 (Rattus norvegicus)
DCC interacting NCK-1 (Xenopus tropicalis)
Authored
Garapati, P V  (2008-07-16)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2008-07-16)
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