DCC interacting NCK-1

Stable Identifier
R-HSA-373716
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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DCC interacts with the SH3/SH2 adaptor NCK1 in commissural neurons. This interaction is direct and requires the SH3 but not SH2 domains of NCK1. NCK1 can recruit Rac, Cdc42 and their effectors Pak and N-WASP to the activated receptor, thereby providing a direct link between DCC, Rho GTPases and numerous downstream signaling components that regulate the actin cytoskeleton.

Literature References
PubMed ID Title Journal Year
12149262 The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism

Li, X, Meriane, M, Triki, I, Shekarabi, M, Kennedy, TE, Larose, L, Lamarche-Vane, N

J Biol Chem 2002
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Participant Of
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