Reactome | DCC interaction with Netrin-1

DCC interaction with Netrin-1

Stable Identifier

R-HSA-373711

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Netrin-1 promotes attraction of the commissural neurons to midline cells. It is secreted in the ventral midline (also known as the floor plate). The transmembrane DCC receptor is a Netrin-1 receptor, involved in the attractive effects of Netrin-1. Contact-dependent mechanisms promote extension of growth cones across the floor plate to the contralateral side, whereupon growth cones acquire sensitivity to the midline repellent Slit and grow away from the midline.
Netrin-1 binds directly to the fifth Fibronectin III motif of DCC, thereby inducing DCC clustering through the association between the DCC P3 domains, a process required for an attractive response.

Literature References

PubMed ID	Title	Journal	Year
25123307	The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue Zhang, J, Svergun, DI, Wang, JH, Mertens, HDT, Meijers, R, Schenk, G, Sun, X, Zhang, Y, Chegkazi, M, Finci, LI, Wu, Y, Krüger, N	Neuron	2014
8861902	Deleted in Colorectal Cancer (DCC) encodes a netrin receptor Masu, M, Hinck, L, Keino-Masu, K, Leonardo, ED, Chan, SS, Culotti, JG, Tessier-Lavigne, M	Cell	1996
9950216	Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas Hu, G, Eckstrand, BC, Caca, K, Fearon, ER, Look, AT, Meyerhardt, JA, Lengauer, C, Banavali, S	Cell Growth Differ	1999