Activation of Rac1

Stable Identifier
R-HSA-418856
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Rho GEF's DOCK180 and Trio directly associate with DCC, activate Rac-1 on DCC stimulation and cause cell spreading.

Literature References
PubMed ID Title Journal Year
18212043 Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance

Ghogha, A, Fromont, S, Piché, C, Debant, A, Briançon-Marjollet, A, Castellani, V, Enslen, H, Cloutier, JF, Chebli, K, Triki, I, Lamarche-Vane, N, Nawabi, H, Auziol, C

Mol Cell Biol 2008
18066058 Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling

Li, X, Rao, Y, Gao, X, Liu, G, Wu, J, Xiong, W

Nat Neurosci 2008
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!