Activation of Rac1

Stable Identifier
R-HSA-418856
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Activation of Rac1
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Rho GEF's DOCK180 and Trio directly associate with DCC, activate Rac-1 on DCC stimulation and cause cell spreading.

Literature References
PubMed ID Title Journal Year
18212043 Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance

Ghogha, A, Fromont, S, Piché, C, Debant, A, Briançon-Marjollet, A, Castellani, V, Enslen, H, Cloutier, JF, Chebli, K, Triki, I, Lamarche-Vane, N, Nawabi, H, Auziol, C

Mol Cell Biol 2008
18066058 Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling

Li, X, Rao, Y, Gao, X, Liu, G, Wu, J, Xiong, W

Nat Neurosci 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane]

Physical Entity
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
Activation of Rac1 (Bos taurus)
Activation of Rac1 (Caenorhabditis elegans)
Activation of Rac1 (Canis familiaris)
Activation of Rac1 (Mus musculus)
Activation of Rac1 (Rattus norvegicus)
Authored
Garapati, P V  (2008-07-16)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-04-27)
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