Activation of Rac1

Stable Identifier
R-HSA-418856
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Rho GEF's DOCK180 and Trio directly associate with DCC, activate Rac-1 on DCC stimulation and cause cell spreading.

Literature References
PubMed ID Title Journal Year
18066058 Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling

Li, X, Gao, X, Liu, G, Xiong, W, Wu, J, Rao, Y

Nat Neurosci 2008
18212043 Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance

Briançon-Marjollet, A, Ghogha, A, Nawabi, H, Triki, I, Auziol, C, Fromont, S, Piché, C, Enslen, H, Chebli, K, Cloutier, JF, Castellani, V, Debant, A, Lamarche-Vane, N

Mol Cell Biol 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Rho guanyl-nucleotide exchange factor activity of NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created