Activation of Rac1

Stable Identifier
R-HSA-418856
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Activation of Rac1
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Rho GEF's DOCK180 and Trio directly associate with DCC, activate Rac-1 on DCC stimulation and cause cell spreading.

Literature References
PubMed ID Title Journal Year
18066058 Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling

Li, X, Gao, X, Liu, G, Xiong, W, Wu, J, Rao, Y

Nat Neurosci 2008
18212043 Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance

Briançon-Marjollet, A, Ghogha, A, Nawabi, H, Triki, I, Auziol, C, Fromont, S, Piché, C, Enslen, H, Chebli, K, Cloutier, JF, Castellani, V, Debant, A, Lamarche-Vane, N

Mol Cell Biol 2008
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
Rho guanyl-nucleotide exchange factor activity of NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane]
Physical Entity
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane]
Activity
Rho guanyl-nucleotide exchange factor activity (0005089)
Orthologous Events
Activation of Rac1 (Bos taurus)
Activation of Rac1 (Caenorhabditis elegans)
Activation of Rac1 (Danio rerio)
Activation of Rac1 (Mus musculus)
Activation of Rac1 (Rattus norvegicus)
Activation of Rac1 (Xenopus tropicalis)
Authored
Garapati, P V  (2008-07-16)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-04-27)