Reactome | Activation of Rac1

Activation of Rac1

Stable Identifier

R-HSA-418856

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Rho GEF's DOCK180 and Trio directly associate with DCC, activate Rac-1 on DCC stimulation and cause cell spreading.

Literature References

PubMed ID	Title	Journal	Year
18066058	Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling Li, X, Gao, X, Liu, G, Xiong, W, Wu, J, Rao, Y	Nat Neurosci	2008
18212043	Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance Briançon-Marjollet, A, Ghogha, A, Nawabi, H, Triki, I, Auziol, C, Fromont, S, Piché, C, Enslen, H, Chebli, K, Cloutier, JF, Castellani, V, Debant, A, Lamarche-Vane, N	Mol Cell Biol	2008

Participants

Input

Output

Participant Of

hasEvent

DCC mediated attractive signaling

Catalyst Activity

Title

Rho guanyl-nucleotide exchange factor activity of NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane]

Physical Entity

NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane]

Activity

Rho guanyl-nucleotide exchange factor activity (0005089)

Orthologous Events

Activation of Rac1 (Caenorhabditis elegans)

Activation of Rac1 (Danio rerio)

Activation of Rac1 (Mus musculus)

Activation of Rac1 (Rattus norvegicus)

Activation of Rac1 (Xenopus tropicalis)

Authored

Garapati, P V (2008-07-16)