When Netrin-1 binds to the DCC-NCK1 complex, a conformational change in NCK1 promotes interaction between the SH2 domain proteins, leading to recruitment and activation of RhoGEFs DOCK180 and Trio. These GEFs mediate Netrin-1 signaling in axon outgrowth and guidance through their ability to activate Rac1 and Cdc42.
Shekarabi, M, Kennedy, TE
Shekarabi, M, Moore, SW, Tritsch, NX, Morris, SJ, Bouchard, JF, Kennedy, TE
Briançon-Marjollet, A, Ghogha, A, Nawabi, H, Triki, I, Auziol, C, Fromont, S, Piché, C, Enslen, H, Chebli, K, Cloutier, JF, Castellani, V, Debant, A, Lamarche-Vane, N
Li, X, Meriane, M, Triki, I, Shekarabi, M, Kennedy, TE, Larose, L, Lamarche-Vane, N
Li, X, Gao, X, Liu, G, Xiong, W, Wu, J, Rao, Y
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