Reactome | RhoGTPase GEF's recruited to DCC

RhoGTPase GEF's recruited to DCC

Stable Identifier

R-HSA-418858

Type

Reaction

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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When Netrin-1 binds to the DCC-NCK1 complex, a conformational change in NCK1 promotes interaction between the SH2 domain proteins, leading to recruitment and activation of RhoGEFs DOCK180 and Trio. These GEFs mediate Netrin-1 signaling in axon outgrowth and guidance through their ability to activate Rac1 and Cdc42.

Literature References

PubMed ID	Title	Journal	Year
15788770	Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion Bouchard, JF, Tritsch, NX, Shekarabi, M, Moore, SW, Kennedy, TE, Morris, SJ	J Neurosci	2005
11817894	The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1 Shekarabi, M, Kennedy, TE	Mol Cell Neurosci	2002
18212043	Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance Ghogha, A, Fromont, S, Piché, C, Debant, A, Briançon-Marjollet, A, Castellani, V, Enslen, H, Cloutier, JF, Chebli, K, Triki, I, Lamarche-Vane, N, Nawabi, H, Auziol, C	Mol Cell Biol	2008
12149262	The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism Larose, L, Li, X, Meriane, M, Triki, I, Lamarche-Vane, N, Shekarabi, M, Kennedy, TE	J Biol Chem	2002
18066058	Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling Li, X, Rao, Y, Gao, X, Liu, G, Wu, J, Xiong, W	Nat Neurosci	2008