RhoGTPase GEF's recruited to DCC

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

When Netrin-1 binds to the DCC-NCK1 complex, a conformational change in NCK1 promotes interaction between the SH2 domain proteins, leading to recruitment and activation of RhoGEFs DOCK180 and Trio. These GEFs mediate Netrin-1 signaling in axon outgrowth and guidance through their ability to activate Rac1 and Cdc42.

Literature References
PubMed ID Title Journal Year
15788770 Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion

Bouchard, JF, Tritsch, NX, Shekarabi, M, Moore, SW, Kennedy, TE, Morris, SJ

J Neurosci 2005
11817894 The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1

Shekarabi, M, Kennedy, TE

Mol Cell Neurosci 2002
18212043 Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance

Ghogha, A, Fromont, S, Piché, C, Debant, A, Briançon-Marjollet, A, Castellani, V, Enslen, H, Cloutier, JF, Chebli, K, Triki, I, Lamarche-Vane, N, Nawabi, H, Auziol, C

Mol Cell Biol 2008
12149262 The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism

Larose, L, Li, X, Meriane, M, Triki, I, Lamarche-Vane, N, Shekarabi, M, Kennedy, TE

J Biol Chem 2002
18066058 Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling

Li, X, Rao, Y, Gao, X, Liu, G, Wu, J, Xiong, W

Nat Neurosci 2008
Orthologous Events
Cite Us!