Reactome | RhoGTPase GEF's recruited to DCC

RhoGTPase GEF's recruited to DCC

Stable Identifier

R-HSA-418858

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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When Netrin-1 binds to the DCC-NCK1 complex, a conformational change in NCK1 promotes interaction between the SH2 domain proteins, leading to recruitment and activation of RhoGEFs DOCK180 and Trio. These GEFs mediate Netrin-1 signaling in axon outgrowth and guidance through their ability to activate Rac1 and Cdc42.

Literature References

PubMed ID	Title	Journal	Year
15788770	Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion Shekarabi, M, Moore, SW, Tritsch, NX, Morris, SJ, Bouchard, JF, Kennedy, TE	J Neurosci	2005
11817894	The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1 Shekarabi, M, Kennedy, TE	Mol Cell Neurosci	2002
18212043	Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance Briançon-Marjollet, A, Ghogha, A, Nawabi, H, Triki, I, Auziol, C, Fromont, S, Piché, C, Enslen, H, Chebli, K, Cloutier, JF, Castellani, V, Debant, A, Lamarche-Vane, N	Mol Cell Biol	2008
12149262	The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism Li, X, Meriane, M, Triki, I, Shekarabi, M, Kennedy, TE, Larose, L, Lamarche-Vane, N	J Biol Chem	2002
18066058	Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling Li, X, Gao, X, Liu, G, Xiong, W, Wu, J, Rao, Y	Nat Neurosci	2008