Reactome | Activation of Cdc42

Activation of Cdc42

Stable Identifier

R-HSA-418850

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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RhoGEF complexed with Netrin-1-DCC induces guanine nucleotide exchange by Cdc42, activating it. Activated Cdc42 activates N-WASP, which promotes the nucleation of F-actin via the Arp2/3 complex. Netrin-1, via DCC, influences cellular motility by regulating actin-based membrane extension through the activation of Cdc42.

Literature References

PubMed ID	Title	Journal	Year
11817894	The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1 Shekarabi, M, Kennedy, TE	Mol Cell Neurosci	2002
15788770	Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion Shekarabi, M, Moore, SW, Tritsch, NX, Morris, SJ, Bouchard, JF, Kennedy, TE	J Neurosci	2005

Participants

Input

Output

Participant Of

hasEvent

DCC mediated attractive signaling

Catalyst Activity

Title

Rho guanyl-nucleotide exchange factor activity of NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane]

Physical Entity

NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane]

Activity

Rho guanyl-nucleotide exchange factor activity (0005089)

Orthologous Events

Activation of Cdc42 (Caenorhabditis elegans)

Activation of Cdc42 (Canis familiaris)

Activation of Cdc42 (Mus musculus)

Activation of Cdc42 (Rattus norvegicus)

Activation of Cdc42 (Xenopus tropicalis)

Authored

Garapati, P V (2008-07-16)