RhoGEF complexed with Netrin-1-DCC induces guanine nucleotide exchange by Cdc42, activating it. Activated Cdc42 activates N-WASP, which promotes the nucleation of F-actin via the Arp2/3 complex. Netrin-1, via DCC, influences cellular motility by regulating actin-based membrane extension through the activation of Cdc42.
Shekarabi, M, Kennedy, TE
Shekarabi, M, Moore, SW, Tritsch, NX, Morris, SJ, Bouchard, JF, Kennedy, TE
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