Activation of Cdc42

Stable Identifier
R-HSA-418850
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Activation of Cdc42
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RhoGEF complexed with Netrin-1-DCC induces guanine nucleotide exchange by Cdc42, activating it. Activated Cdc42 activates N-WASP, which promotes the nucleation of F-actin via the Arp2/3 complex. Netrin-1, via DCC, influences cellular motility by regulating actin-based membrane extension through the activation of Cdc42.

Literature References
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
Rho guanyl-nucleotide exchange factor activity of NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane]
Physical Entity
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane]
Activity
Rho guanyl-nucleotide exchange factor activity (0005089)
Orthologous Events
Activation of Cdc42 (Bos taurus)
Activation of Cdc42 (Caenorhabditis elegans)
Activation of Cdc42 (Canis familiaris)
Activation of Cdc42 (Danio rerio)
Activation of Cdc42 (Mus musculus)
Activation of Cdc42 (Rattus norvegicus)
Activation of Cdc42 (Xenopus tropicalis)
Authored
Garapati, P V  (2008-07-16)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-04-27)