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BCHE [plasma membrane]
Stable Identifier
R-HSA-3640835
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Butyrylcholinesterase, Cholinesterase, CHLE_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
Glycerophospholipid biosynthesis (Homo sapiens)
Synthesis of PC (Homo sapiens)
AcCho is hydrolyzed to Cho and acetate by ACHE (Homo sapiens)
Cholinesterase [plasma membrane] (Homo sapiens)
BCHE [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter clearance (Homo sapiens)
AcCho is hydrolyzed to Cho and acetate by ACHE (Homo sapiens)
Cholinesterase [plasma membrane] (Homo sapiens)
BCHE [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P06276 BCHE
Gene Names
BCHE, CHE1
Chain
signal peptide:1-28, chain:29-602
Reference Genes
BioGPS Gene:590 BCHE
COSMIC (genes):BCHE BCHE
CTD Gene:590 BCHE
dbSNP Gene:590 BCHE
ENSEMBL:ENSG00000114200 BCHE
HGNC:983 BCHE
KEGG:hsa:590 BCHE
Monarch:590 BCHE
NCBI Gene:590 BCHE
OMIM:177400 BCHE
UCSC:P06276 BCHE
Reference Transcript
RefSeq:NM_000055.4 BCHE
Other Identifiers
11746149_x_at
11751833_a_at
16961172
205433_PM_at
205433_at
2703904
2703905
2703906
2703907
2703909
2703910
2703912
2703913
2703918
2703919
2703920
2703922
2703923
37841_at
590
8091867
A_23_P212050
GE58204
GO:0001540
GO:0003824
GO:0003990
GO:0004104
GO:0005515
GO:0005576
GO:0005615
GO:0005641
GO:0005783
GO:0005788
GO:0005886
GO:0006581
GO:0006805
GO:0007584
GO:0007612
GO:0008285
GO:0009410
GO:0014016
GO:0016486
GO:0016787
GO:0016788
GO:0019695
GO:0019899
GO:0030154
GO:0033265
GO:0042802
GO:0043226
GO:0043279
GO:0050783
GO:0050805
GO:0050877
GO:0051384
GO:0051593
GO:0051604
GO:0052689
GO:0072562
HMNXSV003008228
ILMN_1685641
ILMN_2176592
M16474_s_at
PH_hs_0025160
TC03001970.hg
g4557350_3p_at
Participates
as a candidate of
Cholinesterase [plasma membrane] (Homo sapiens)
Other forms of this molecule
BCHE [extracellular region]
Inferred To
bchel [plasma membrane]
(Xenopus tropicalis)
BCHE [plasma membrane]
(Gallus gallus)
ace-1 [plasma membrane]
(Caenorhabditis elegans)
Ace [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_000046.1
ZINC - World Drugs
CHLE_HUMAN
Guide to Pharmacology - Targets
2471
OpenTargets
ENSG00000114200
ENSEMBL
ENSG00000114200
,
ENSP00000264381
,
ENST00000264381
ZINC - FDA approved
CHLE_HUMAN
ZINC - Substances
CHLE_HUMAN
ZINC - Biogenic
CHLE_HUMAN
ZINC target
P06276
PRO
P06276
GlyGen
P06276
PDB
2Y1K
,
2J4C
,
4BBZ
,
2XMB
,
2XMC
,
6SAM
,
6ESJ
,
6EP4
,
2WIF
,
7QHD
,
4XII
,
6F7Q
,
7BO3
,
6ESY
,
2XMD
,
2WIJ
,
2WSL
,
2XQJ
,
7QHE
,
8QTW
,
1P0Q
,
6XTA
,
8QTX
,
7AWH
,
2XMG
,
8CGO
,
3DJY
,
7AWG
,
6EMI
,
6I0B
,
1XLW
,
6QAB
,
1XLU
,
6I0C
,
4B0P
,
6QAC
,
6T9S
,
6ZWI
,
3DKK
,
7AWI
,
7Q1N
,
4TPK
,
5DYW
,
6T9P
,
6EYF
,
6QAD
,
1P0I
,
1P0M
,
1P0P
,
4AQD
,
7BO4
,
2WIL
,
2WID
,
6RUA
,
2PM8
,
2XQF
,
7QBR
,
5K5E
,
2XQG
,
2WIG
,
6I2T
,
7QBQ
,
2XQI
,
8AM1
,
8AM2
,
2WIK
,
8AI7
,
5LKR
,
6QAA
,
3O9M
,
7Q1O
,
2XQK
,
7Q1P
,
7Q1M
,
6R6W
,
4B0O
,
6R6V
,
1XLV
,
6EZ2
,
5DYT
,
7AIY
,
5NN0
,
7ZPB
,
6EQQ
,
4AXB
,
6EQP
,
7BGC
,
5DYY
,
6QAE
,
4BDS
,
7AMZ
ZINC - Investigational
CHLE_HUMAN
ZINC - Metabolites
CHLE_HUMAN
IntEnz
3.1.1.8
HPA
ENSG00000114200-BCHE
GeneCards
BCHE
Pharos - Targets
P06276
Orphanet
BCHE
ZINC - Predictions - Purchasable
CHLE_HUMAN
HMDB Protein
HMDBP00525
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06276 BCHE
2
BCHE [plasma membrane]
(R-HSA-3640835)
BCHE [extracellular region]
(R-HSA-434469)
0.842
8
UniProt:Q9UK22 FBXO2
1
FBXO2 [cytosol]
(R-HSA-976044)
0.643
3
UniProt:Q08397 LOXL1
3
LOXL1(26-94) [extracellular region]
(R-HSA-2022105)
LOXL1(26-574) [extracellular region]
(R-HSA-2022093)
LOXL1 [extracellular region]
(R-HSA-2022107)
0.643
3
UniProt:O75356 ENTPD5
1
ENTPD5 [extracellular region]
(R-HSA-8851371)
0.643
3
UniProt:P02814 SMR3B
0.564
2
UniProt:P55212 CASP6
5
CASP6(194-293) [cytosol]
(R-HSA-266128)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
0.556
3
UniProt:O75190-2 DNAJB6
0.556
3
UniProt:O14901 KLF11
0.556
3
UniProt:P46379-2 BAG6
0.556
3
UniProt:P54252 ATXN3
2
ATXN3 [nucleoplasm]
(R-HSA-6783285)
ATXN3 [cytosol]
(R-HSA-5625607)
0.556
3
UniProt:P13473-2 P134732
0.556
3
UniProt:P62826 RAN
2
RAN [cytosol]
(R-HSA-165540)
RAN [nucleoplasm]
(R-HSA-165528)
0.556
3
UniProt:O75400-2 PRPF40A
0.556
3
UniProt:P67812 SEC11A
1
SEC11A [endoplasmic reticulum membrane]
(R-HSA-265024)
0.556
3
UniProt:Q12797 ASPH
2
ASPH [endoplasmic reticulum membrane]
(R-HSA-5490331)
ASPH [endoplasmic reticulum lumen]
(R-HSA-9631383)
0.527
2
UniProt:Q08043 ACTN3
1
ACTN3 [cytosol]
(R-HSA-390565)
0.527
2
UniProt:Q9NSV4 DIAPH3
1
DIAPH3 [cytosol]
(R-HSA-5666125)
0.527
2
UniProt:Q6XE38 SG1D4
0.527
2
UniProt:O00401 WASL
4
p-Y256-WASL [cytosol]
(R-HSA-2197672)
N-WASP [cytosol]
(R-HSA-201873)
WASL [plasma membrane]
(R-HSA-203010)
WASL [endocytic vesicle membrane]
(R-HSA-535012)
0.527
2
UniProt:P59665 DEFA1
9
DEFA1(20-94) [Golgi lumen]
(R-HSA-1467282)
DEFA1(66-94) [Golgi lumen]
(R-HSA-975663)
DEFA1(20-65) [Golgi lumen]
(R-HSA-8864970)
DEFA1(1-94) [Golgi lumen]
(R-HSA-1467215)
DEFA1(66-94) [extracellular region]
(R-HSA-1461998)
DEFA1(66-94) [azurophil granule lumen]
(R-HSA-1470038)
DEFA1(65-94) [extracellular region]
(R-HSA-1462022)
omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region]
(R-HSA-1972397)
DEFA1(65-94) [azurophil granule lumen]
(R-HSA-1470053)
0.527
2
UniProt:Q9NZB2 F120A
0.527
2
UniProt:Q14766 LTBP1
3
LTBP1 [extracellular region]
(R-HSA-2161391)
LTBP1 [endoplasmic reticulum lumen]
(R-HSA-8956770)
p-LTBP1 [endoplasmic reticulum lumen]
(R-HSA-8957050)
0.527
2
UniProt:O95968 SG1D1
0.527
2
UniProt:Q96HR8 NAF1
0.527
2
UniProt:O60832 DKC1
1
DKC1 [nucleoplasm]
(R-HSA-163102)
0.527
2
UniProt:Q9NPE3 NOP10
1
NOP10 [nucleoplasm]
(R-HSA-6790665)
0.527
2
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