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ACTN3 [cytosol]
Stable Identifier
R-HSA-390565
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Alpha-actinin-3, ACTN3_HUMAN
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Nephrin family interactions (Homo sapiens)
Interaction of nephrin with adherens junction-associated proteins (Homo sapiens)
Nephrin dimer:adherins junction-associated proteins [plasma membrane] (Homo sapiens)
adherens junction-associated proteins [cytosol] (Homo sapiens)
Alpha-actinin [cytosol] (Homo sapiens)
ACTN3 [cytosol] (Homo sapiens)
adherens junction-associated proteins [cytosol] (Homo sapiens)
Alpha-actinin [cytosol] (Homo sapiens)
ACTN3 [cytosol] (Homo sapiens)
Muscle contraction (Homo sapiens)
Striated Muscle Contraction (Homo sapiens)
ATP Hydrolysis By Myosin (Homo sapiens)
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Z Disk Complex [cytosol] (Homo sapiens)
Alpha-actinin [cytosol] (Homo sapiens)
ACTN3 [cytosol] (Homo sapiens)
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Z Disk Complex [cytosol] (Homo sapiens)
Alpha-actinin [cytosol] (Homo sapiens)
ACTN3 [cytosol] (Homo sapiens)
Calcium Binds Troponin-C (Homo sapiens)
Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Z Disk Complex [cytosol] (Homo sapiens)
Alpha-actinin [cytosol] (Homo sapiens)
ACTN3 [cytosol] (Homo sapiens)
Inactive Sarcomere Protein Complex [cytosol] (Homo sapiens)
Z Disk Complex [cytosol] (Homo sapiens)
Alpha-actinin [cytosol] (Homo sapiens)
ACTN3 [cytosol] (Homo sapiens)
Myosin Binds ATP (Homo sapiens)
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Z Disk Complex [cytosol] (Homo sapiens)
Alpha-actinin [cytosol] (Homo sapiens)
ACTN3 [cytosol] (Homo sapiens)
Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Z Disk Complex [cytosol] (Homo sapiens)
Alpha-actinin [cytosol] (Homo sapiens)
ACTN3 [cytosol] (Homo sapiens)
Release Of ADP From Myosin (Homo sapiens)
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Z Disk Complex [cytosol] (Homo sapiens)
Alpha-actinin [cytosol] (Homo sapiens)
ACTN3 [cytosol] (Homo sapiens)
Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Z Disk Complex [cytosol] (Homo sapiens)
Alpha-actinin [cytosol] (Homo sapiens)
ACTN3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q08043 ACTN3
Gene Names
ACTN3
Chain
chain:1-901
Reference Genes
BioGPS Gene:89 ACTN3
COSMIC (genes):ACTN3 ACTN3
CTD Gene:89 ACTN3
dbSNP Gene:89 ACTN3
ENSEMBL:ENSG00000248746 ACTN3
HGNC:165 ACTN3
KEGG:hsa:89 ACTN3
Monarch:89 ACTN3
NCBI Gene:89 ACTN3
OMIM:102574 ACTN3
UCSC:Q08043 ACTN3
Reference Transcript
RefSeq:NM_001258371.2 ACTN3
RefSeq:NM_001104.3 ACTN3
Other Identifiers
11730995_a_at
16727502
206891_PM_at
206891_at
3336325
3336326
3336327
3336328
3336329
3336330
3336331
3336332
3336333
3336334
3336335
3336336
3336337
3336338
3336339
3336340
3336341
3336342
3336343
3336344
3336345
3336346
3336347
3336348
3336349
3336350
34499_at
3832646
7941662
89
GO:0003012
GO:0003779
GO:0005178
GO:0005198
GO:0005509
GO:0005515
GO:0005737
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005903
GO:0005925
GO:0007010
GO:0008092
GO:0008307
GO:0014728
GO:0014732
GO:0014883
GO:0014894
GO:0030017
GO:0030018
GO:0030036
GO:0030054
GO:0030864
GO:0031143
GO:0031448
GO:0034330
GO:0042802
GO:0042981
GO:0042995
GO:0043226
GO:0044325
GO:0045820
GO:0046872
GO:0048041
GO:0048633
GO:0048743
GO:0048856
GO:0051015
GO:0055001
GO:0060349
GO:0070062
GO:0070885
GO:0090257
GO:0090324
GO:0120163
GO:1900159
GO:1901078
GO:1903715
GO:1904025
HMNXSV003029765
ILMN_1665691
M86407_at
PH_hs_0026019
TC11000671.hg
g4557240_3p_at
Participates
as a member of
Alpha-actinin [cytosol] (Homo sapiens)
Alpha-actinin [cytosol] (Homo sapiens)
Inferred To
Actn3 [cytosol]
(Rattus norvegicus)
ACTN3 [cytosol]
(Bos taurus)
ACTN3 [cytosol]
(Canis familiaris)
ACTN3 [cytosol]
(Mus musculus)
ACTN3 [cytosol]
(Sus scrofa)
Cross References
ENSEMBL
ENSP00000426797
,
ENST00000513398
OpenTargets
ENSG00000248746
HPA
ENSG00000248746-ACTN3
PRO
Q08043
Pharos - Targets
Q08043
GlyGen
Q08043
PDB
1TJT
,
3LUE
,
1WKU
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P12814 ACTN1
3
ACTN1 [cytosol]
(R-HSA-354096)
ACTN1 [platelet alpha granule lumen]
(R-HSA-349724)
ACTN1 [extracellular region]
(R-HSA-349722)
0.556
3
UniProt:O95863 SNAI1
1
SNAI1 [nucleoplasm]
(R-HSA-2980903)
0.556
3
UniProt:Q13882 PTK6
5
PTK6 [cytosol]
(R-HSA-8848000)
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
UniProt:O75604 USP2
2
USP2 [cytosol]
(R-HSA-5212661)
USP2 [nucleoplasm]
(R-HSA-5689946)
0.556
3
UniProt:O14561 NDUFAB1
4
octanoyl-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-9857608)
NDUFAB1 [mitochondrial inner membrane]
(R-HSA-163925)
PPANT-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-8933545)
Mal-PPANT-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-8934586)
0.556
3
UniProt:P06276 BCHE
2
BCHE [plasma membrane]
(R-HSA-3640835)
BCHE [extracellular region]
(R-HSA-434469)
0.527
2
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