Reactome | p-LTBP1 [endoplasmic reticulum lumen]

p-LTBP1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8957050

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

LTBP1, Latent-transforming growth factor beta-binding protein 1, LTBP1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q14766 LTBP1

Gene Names

LTBP1

Chain

signal peptide:1-23, chain:24-1721

Reference Genes

BioGPS Gene:4052 LTBP1

COSMIC (genes):LTBP1 LTBP1

CTD Gene:4052 LTBP1

dbSNP Gene:4052 LTBP1

ENSEMBL:ENSG00000049323 LTBP1

HGNC:6714 LTBP1

KEGG:hsa:4052 LTBP1

Monarch:4052 LTBP1

NCBI Gene:4052 LTBP1

OMIM:150390 LTBP1

UCSC:Q14766 LTBP1

Reference Transcript

Participates

as a member of

FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

LTBP1 [extracellular region]

LTBP1 [endoplasmic reticulum lumen]

Inferred To

phospho-Ltbp1 [endoplasmic reticulum lumen] (Mus musculus)

phospho-Ltbp1 [endoplasmic reticulum lumen] (Rattus norvegicus)

phospho-p-LTBP1 [endoplasmic reticulum lumen] (Gallus gallus)

phospho-nid-1 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

phospho-LTBP1 [endoplasmic reticulum lumen] (Bos taurus)

phospho-LTBP1 [endoplasmic reticulum lumen] (Canis familiaris)

phospho-LTBP1 [endoplasmic reticulum lumen] (Sus scrofa)

phospho-ltbp1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_001159737.2, NP_001159737.1, NP_000618.3, NP_001159738.1, NP_996826.3, NP_996826.2, XP_011531155.1, NP_001159736.1

OpenTargets

ENSG00000049323

ENSEMBL

ENST00000407925, ENST00000404525, ENSG00000049323, ENSP00000386043, ENSP00000384091, ENSP00000385359, ENST00000404816

HPA

ENSG00000049323-LTBP1

GeneCards

LTBP1

PRO

Q14766

Pharos - Targets

Q14766

GlyGen

Q14766

PDB

1KSQ

HMDB Protein

HMDBP14565

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08254 MMP3	6	MMP3(100-477) [extracellular region] (R-HSA-1430778) MMP3 [extracellular region] (R-HSA-8943665) MMP3(18-477) [extracellular region] (R-HSA-1604707) MMP3(55-477) [extracellular region] (R-HSA-1604735) MMP3(18-54) [extracellular region] (R-HSA-1604705) MMP3(55-99) [extracellular region] (R-HSA-1604687)	0.643	3
UniProt:P06276 BCHE	2	BCHE [plasma membrane] (R-HSA-3640835) BCHE [extracellular region] (R-HSA-434469)	0.527	2
UniProt:P09238 MMP10	2	MMP10(18-476) [extracellular region] (R-HSA-1604748) MMP10 [extracellular region] (R-HSA-1442488)	0.527	2
UniProt:Q01523 DEFA5	5	DEFA5(1-94) [Golgi lumen] (R-HSA-1467267) DEFA5(20-94) [Golgi lumen] (R-HSA-1467208) DEFA5(20-94) [secretory granule lumen] (R-HSA-1471358) DEFA5(20-94) [extracellular region] (R-HSA-1471344) DEFA5(?-94) [extracellular region] (R-HSA-1462017)	0.527	2
UniProt:Q04721 NOTCH2	18	NOTCH2(1582-1665) [extracellular region] (R-HSA-157652) NOTCH2(1666-1696) [plasma membrane] (R-HSA-157628) NEXT2 [plasma membrane] (R-HSA-157225) NICD2 [cytosol] (R-HSA-157642) NICD2 [nucleoplasm] (R-HSA-157942) Glc,GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911428) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911417) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911505) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [Golgi membrane] (R-HSA-1983676) NOTCH2(1582-2471) [Golgi membrane] (R-HSA-157017) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [extracellular region] (R-HSA-1983678) NOTCH2(1582-2471) [plasma membrane] (R-HSA-157228) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [Golgi membrane] (R-HSA-1472874) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467379) 18xFucT-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467363) Pre-NOTCH2 [endoplasmic reticulum membrane] (R-HSA-157025) FRINGE-modified NOTCH2 extracellular fragment (NECD2) [Golgi membrane] (R-HSA-1911520) FRINGE-modified NOTCH2 Extracellular Fragment (NECD2) [plasma membrane] (R-HSA-1911518)	0.527	2

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