Reactome | CHD8 [nucleoplasm]

CHD8 [nucleoplasm]

Stable Identifier

R-HSA-3221598

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Chromodomain-helicase-DNA-binding protein 8, Helicase with SNF2 domain 1, HELSNF1, KIAA1564

Locations in the PathwayBrowser for interactor UniProt:P61964 WDR5

Expand all

External Reference Information

External Reference

UniProt:Q9HCK8 CHD8

Gene Names

CHD8, HELSNF1, KIAA1564

Chain

chain:1-2581

Reference Genes

BioGPS Gene:57680 CHD8

COSMIC - genes:CHD8 CHD8

CTD Gene:57680 CHD8

dbSNP Gene:57680 CHD8

ENSEMBL:ENSG00000100888 CHD8

HGNC:20153 CHD8

KEGG:hsa:57680 CHD8

Monarch:57680 CHD8

NCBI Gene:57680 CHD8

OMIM:610528 CHD8

UCSC:Q9HCK8 CHD8

Reference Transcript

Participates

as a component of

as an input of

as a member of

Inferred To

kis [nucleoplasm] (Drosophila melanogaster)

chd-7 [nucleoplasm] (Caenorhabditis elegans)

CHD8 [nucleoplasm] (Bos taurus)

CHD8 [nucleoplasm] (Canis familiaris)

CHD8 [nucleoplasm] (Danio rerio)

CHD8 [nucleoplasm] (Dictyostelium discoideum)

CHD8 [nucleoplasm] (Gallus gallus)

CHD8 [nucleoplasm] (Mus musculus)

CHD8 [nucleoplasm] (Rattus norvegicus)

CHD8_tv1 [nucleoplasm] (Sus scrofa)

Homologues of CHD8 [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_065971.2, NP_001164100.1

OpenTargets

ENSG00000100888

ENSEMBL

ENST00000557364, ENST00000646647, ENST00000430710, ENSP00000494402, ENSP00000451601, ENSP00000406288, ENSG00000100888, ENSP00000495070, ENST00000643469, ENSP00000495240, ENST00000645929

HPA

ENSG00000100888-CHD8

GeneCards

CHD8

PRO

Q9HCK8

Pharos - Targets

Q9HCK8

GlyGen

Q9HCK8

Orphanet

CHD8

HMDB Protein

HMDBP11645

PDB

2CKA, 2DL6

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.725	4
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.623	3
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.527	2
UniProt:O60684 KPNA6	2	KPNA6 [nucleoplasm] (R-HSA-9734665) KPNA6 [cytosol] (R-HSA-9734672)	0.527	2
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [secretory granule lumen] (R-HSA-6800917)	0.527	3
UniProt:P67870 CSNK2B	5	CSNK2B [cytosol] (R-HSA-201693) CSNK2B [nucleoplasm] (R-HSA-6805067) CSNK2B [ficolin-1-rich granule lumen] (R-HSA-6801290) CSNK2B [extracellular region] (R-HSA-6806508) CSNK2B [secretory granule lumen] (R-HSA-6801319)	0.527	2
UniProt:Q9H5V7 IKZF5			0.527	4
UniProt:O95365 ZBT7A			0.508	2
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.499	2
UniProt:O00154 ACOT7	1	ACOT7 [cytosol] (R-HSA-5690040)	0.499	2
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.499	2
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.483	2
UniProt:Q13595 TRA2A			0.483	2
UniProt:P26368 U2AF2	2	U2AF2 [nucleoplasm] (R-HSA-71987) 5OHK15,276-U2AF2 [nucleoplasm] (R-HSA-9630011)	0.483	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.483	2
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.483	2
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.483	2
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.483	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.483	2
UniProt:P49711 CTCF	1	CTCF [nucleoplasm] (R-HSA-3782562)	0.463	3

Cite Us!