CHD8 is a ATP-dependent chromatin remodeling factor that binds directly to beta-catenin to repress transcription of WNT target genes (Thompson et al, 2008; Sakamoto et al, 2000). ChIP studies show that CHD8 is recruited to the promoters of several beta-catenin-responsive targets, and knockdown of CHD8 results in induction of these target genes in vivo (Thompson et al, 2008). An N-terminal fragment of CHD was independently identified as the rat protein Duplin. Duplin was shown to negatively regulate WNT target gene expression by competing with TCF7L2 for beta-catenin binding (Sakamoto et al, 2000; Kobayashi et al, 2002). A corresponding fragment of CHD8 has not been identified in human cells and its significance is not clear.
Sakamoto, I, Kishida, S, Fukui, A, Kishida, M, Yamamoto, H, Hino, S, Michiue, T, Takada, S, Asashima, M, Kikuchi, A
Thompson, BA, Tremblay, V, Lin, G, Bochar, DA
Kadoya, T, Kishida, S, Fukui, A, Hinoi, T, Michiue, T, Asashima, M, Kikuchi, A
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