CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CHD8 is a ATP-dependent chromatin remodeling factor that binds directly to beta-catenin to repress transcription of WNT target genes (Thompson et al, 2008; Sakamoto et al, 2000). ChIP studies show that CHD8 is recruited to the promoters of several beta-catenin-responsive targets, and knockdown of CHD8 results in induction of these target genes in vivo (Thompson et al, 2008). An N-terminal fragment of CHD was independently identified as the rat protein Duplin. Duplin was shown to negatively regulate WNT target gene expression by competing with TCF7L2 for beta-catenin binding (Sakamoto et al, 2000; Kobayashi et al, 2002). A corresponding fragment of CHD8 has not been identified in human cells and its significance is not clear.

Literature References
PubMed ID Title Journal Year
18378692 CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes

Thompson, BA, Bochar, DA, Lin, G, Tremblay, V

Mol. Cell. Biol. 2008
10921920 A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation

Kishida, M, Kikuchi, A, Asashima, M, Sakamoto, I, Takada, S, Hino, S, Michiue, T, Kishida, S, Fukui, A, Yamamoto, H

J. Biol. Chem. 2000
10944533 Inhibition of Wnt signaling pathway by a novel axin-binding protein

Kikuchi, A, Kadoya, T, Asashima, M, Hinoi, T, Michiue, T, Kishida, S, Fukui, A

J. Biol. Chem. 2000
Orthologous Events
Cite Us!