Reactome | GADD45A binds PCNA

GADD45A binds PCNA

Stable Identifier

R-HSA-6791109

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Homo sapiens)
        
        GADD45A binds PCNA (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

GADD45A binds PCNA homotrimer (Smith et al. 1994, Hall et al. 1995, Sanchez et al. 2010). The consequences of this interaction are not clear. Binding to GADD45A may negatively regulate PCNA-mediated DNA synthesis during S phase of the cell cycle or it may promote PCNA-mediated DNA repair synthesis (Smith et al. 1994, Kim et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
20460379	Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase Sánchez, R, Pantoja-Uceda, D, Prieto, J, Diercks, T, Marcaida, MJ, Montoya, G, Campos-Olivas, R, Blanco, FJ	J. Biol. Chem.	2010
23485469	A novel role for Gadd45α in base excision repair: modulation of APE1 activity by the direct interaction of Gadd45α with PCNA Kim, HL, Kim, SU, Seo, YR	Biochem. Biophys. Res. Commun.	2013
7973727	Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen Smith, ML, Chen, IT, Zhan, Q, Bae, I, Chen, CY, Gilmer, TM, Kastan, MB, O'Connor, PM, Fornace, AJ	Science	1994
7784094	Characterisation of the interaction between PCNA and Gadd45 Hall, PA, Kearsey, JM, Coates, PJ, Norman, DG, Warbrick, E, Cox, LS	Oncogene	1995