Reactome | GADD45A binds AURKA

GADD45A binds AURKA

Stable Identifier

R-HSA-6791235

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Homo sapiens)
        
        GADD45A binds AURKA (Homo sapiens)

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GADD45A binds Aurora-A protein kinase (AURKA). GADD45A inhibits the kinase activity of AURKA and AURKA-induced centrosome amplification, thus interfering with the G2/M transition (Shao et al. 2006, Sanchez et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20460379	Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase Prieto, J, Marcaida, MJ, Montoya, G, Campos-Olivas, R, Blanco, FJ, Sánchez, R, Pantoja-Uceda, D, Diercks, T	J. Biol. Chem.	2010
16772293	Gadd45a interacts with aurora-A and inhibits its kinase activity Zhao, Z, Dong, L, Wang, Y, Shao, S, Jin, S, Fu, M, Fan, F, Xu, N, Song, Y, Zhan, Q, Fan, W, Wang, X, Tong, T	J. Biol. Chem.	2006