GADD45A binds AURKA

Stable Identifier
R-HSA-6791235
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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GADD45A binds Aurora-A protein kinase (AURKA). GADD45A inhibits the kinase activity of AURKA and AURKA-induced centrosome amplification, thus interfering with the G2/M transition (Shao et al. 2006, Sanchez et al. 2010).

Literature References
PubMed ID Title Journal Year
16772293 Gadd45a interacts with aurora-A and inhibits its kinase activity

Shao, S, Wang, Y, Jin, S, Song, Y, Wang, X, Fan, W, Zhao, Z, Fu, M, Tong, T, Dong, L, Fan, F, Xu, N, Zhan, Q

J. Biol. Chem. 2006
20460379 Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase

Sánchez, R, Pantoja-Uceda, D, Prieto, J, Diercks, T, Marcaida, MJ, Montoya, G, Campos-Olivas, R, Blanco, FJ

J. Biol. Chem. 2010
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